Academic Journal
Differential sex-association between PCSK1 polymorphisms and obesity risk in Portuguese children.
| Title: | Differential sex-association between PCSK1 polymorphisms and obesity risk in Portuguese children. |
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| Authors: | Manco L; Research Centre for Anthropology and Health (CIAS), University of Coimbra, Coimbra, Portugal.; Department of Life Sciences, University of Coimbra, Coimbra, Portugal., Albuquerque D; Research Centre for Anthropology and Health (CIAS), University of Coimbra, Coimbra, Portugal., Aranda B; Research Centre for Anthropology and Health (CIAS), University of Coimbra, Coimbra, Portugal., Rodrigues D; Research Centre for Anthropology and Health (CIAS), University of Coimbra, Coimbra, Portugal., Machado-Rodrigues AM; Research Centre for Anthropology and Health (CIAS), University of Coimbra, Coimbra, Portugal.; Faculty of Sport Sciences and Physical Education, University of Coimbra, Coimbra, Portugal., Padez C; Research Centre for Anthropology and Health (CIAS), University of Coimbra, Coimbra, Portugal.; Department of Life Sciences, University of Coimbra, Coimbra, Portugal. |
| Source: | American journal of human biology : the official journal of the Human Biology Council [Am J Hum Biol] 2024 May; Vol. 36 (5), pp. e24023. Date of Electronic Publication: 2023 Nov 27. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8915029 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6300 (Electronic) Linking ISSN: 10420533 NLM ISO Abbreviation: Am J Hum Biol Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York, NY : Wiley-Blackwell Original Publication: New York, NY : Alan R. Liss, Inc., c1989- |
| MeSH Terms: | Proprotein Convertase 1*/genetics, Portugal/epidemiology ; Obesity/genetics ; Obesity/epidemiology ; Overweight/genetics ; Overweight/epidemiology ; Pediatric Obesity/genetics ; Pediatric Obesity/epidemiology ; Humans ; Child ; Male ; Female ; Case-Control Studies ; Adolescent ; Child, Preschool ; Sex Factors ; Polymorphism, Genetic ; Body Mass Index ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease ; Risk Factors |
| Abstract: | Objectives: The proprotein convertase subtilisin/Kexin type 1 gene (PCSK1) is implicated in hypothalamic appetite control. Several studies have addressed the relationship between PCSK1 polymorphisms and obesity, although conflicting results were observed. We tested the potential association of four PCSK1 variants with the risk of overweight/obesity and related variables in Portuguese children. Methods: This is a case-control study, where four PCSK1 variants, rs6230 (c.-101T>C), rs6232 (p.N221D), rs6235 (p.S690T), and rs3811942 (c.*265T>C), were analyzed in Portuguese children (aged 5-13 years-old). Anthropometric measures were objectively collected and used to provide weight-for-age, height-for-age, and body mass index (BMI) for age. The indices generated were compared to standard reference values of WHO to obtain the corresponding Z-scores. Results: Logistic regression, in the dominant model, revealed no significant associations between the four individual PCSK1 variants and the risk of overweight/obesity in the total population. However, stratifying the sample by sex, a marginally significant association was found between the rs6235 minor C-allele and increased overweight/obesity in boys (n = 345) (OR 1.55 [1.01-2.38] p = .044), but not in girls (n = 340) (OR 0.73 [0.46-1.14] p = .169). Consistently, boys with genotype GG presented lower BMI Z-score (0.62) when compared to those with the genotypes GC + CC (1.04). Testing for different effects in males versus females, a significant interaction was found between the rs6235 polymorphism and sex for BMI Z-score (p = .025). Conclusions: Results of this study suggest for a sex-differentiated association between PCSK1 rs6235 and overweight/ obesity in Portuguese children. (© 2023 Wiley Periodicals LLC.) |
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| Grant Information: | UIDB/00283/2020 Fundação para a Ciência e a Tecnologia; PTDC/DTP-SAP/1520/2014 COMPETE 2020, Portugal 2020 |
| Substance Nomenclature: | EC 3.4.21.93 (Proprotein Convertase 1) EC 3.4.21.93 (PCSK1 protein, human) |
| Entry Date(s): | Date Created: 20231127 Date Completed: 20240501 Latest Revision: 20240806 |
| Update Code: | 20260130 |
| DOI: | 10.1002/ajhb.24023 |
| PMID: | 38009939 |
| Database: | MEDLINE |
| ISSN: | 1520-6300 |
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| DOI: | 10.1002/ajhb.24023 |