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Anti-diabetic and anti-urease potential of Osbeckia nutans Wall. leaves.

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Τίτλος: Anti-diabetic and anti-urease potential of Osbeckia nutans Wall. leaves.
Συγγραφείς: Chelleng N; Natural Product Chemistry Section, CSIR-North East Institute of Science and Technology, Naharlagun, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Hazarika M; Natural Product Chemistry Section, CSIR-North East Institute of Science and Technology, Naharlagun, India., Sonia H; Natural Product Chemistry Section, CSIR-North East Institute of Science and Technology, Naharlagun, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Dihingia A; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Biological Science & Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, India., Manna P; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Biological Science & Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, India., Puzari M; Department of Life Sciences, Dibrugarh University, Dibrugarh, India., Chetia P; Department of Life Sciences, Dibrugarh University, Dibrugarh, India., Tamuly C; Natural Product Chemistry Section, CSIR-North East Institute of Science and Technology, Naharlagun, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Πηγή: Natural product research [Nat Prod Res] 2024 Nov; Vol. 38 (21), pp. 3870-3875. Date of Electronic Publication: 2023 Oct 06.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE
Imprint Name(s): Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-
Ιατρικοί όροι (MeSH): Plant Leaves*/chemistry , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry , Urease*/metabolism , Plant Extracts*/pharmacology , Plant Extracts*/chemistry, alpha-Glucosidases/metabolism ; Flavonoids/pharmacology ; Flavonoids/chemistry ; Glycoside Hydrolase Inhibitors/pharmacology ; Glycoside Hydrolase Inhibitors/chemistry ; Quercetin/pharmacology ; Quercetin/chemistry ; Glucose Transporter Type 4/metabolism ; Helicobacter pylori/drug effects ; Asteraceae/chemistry ; Luteolin/pharmacology ; Luteolin/chemistry ; Glucose/metabolism ; Catechin/pharmacology ; Catechin/chemistry ; Animals
Περίληψη: A study was conducted to investigate the anti-diabetic and anti-urease potential of Osbeckia nutans leaves (ONL). Six compounds, i.e. quercetin-3-O-glucoside, myricetin, shikimic acid, catechin, trans-ferulic acid and luteolin were identified from the butanol sub-fraction, BE2 and the ethyl acetate sub-fraction, EA5 of ONL. BE2 inhibited α-glucosidase and Jack bean urease with IC50 values of 0.036 μg/mL (437.46 μg/mL for acarbose) and 0.327 mg/mL (0.039 mg/mL for thiourea), respectively. In the glucose uptake experiment, BE2 (0.05 mg/mL) treatment resulted in a substantial increase in glucose uptake in free fatty acid (FFA)-treated cells at a concentration 10 times lower than that seen in EA5 (0.5 mg/mL) treated cells. The binding energies of quercetin-3-O-glucoside with α-glucosidase, glucose transporter GLUT4 and H. pylori urease were found to be -94.2585, -219.8271 and -254.391 kcal/mol, respectively. This study revealed that ONL has anti-diabetic and anti-urease abilities and further in-depth research may unveil its full potential.
Contributed Indexing: Keywords: H. pylori urease; Osbeckia nutans; cellular glucose uptake; chemical constituents; molecular docking; α-glucosidase
Substance Nomenclature: 0 (Hypoglycemic Agents)
EC 3.5.1.5 (Urease)
0 (Plant Extracts)
EC 3.2.1.20 (alpha-Glucosidases)
0 (Flavonoids)
0 (Glycoside Hydrolase Inhibitors)
9IKM0I5T1E (Quercetin)
76XC01FTOJ (myricetin)
0 (Glucose Transporter Type 4)
KUX1ZNC9J2 (Luteolin)
IY9XDZ35W2 (Glucose)
8R1V1STN48 (Catechin)
Entry Date(s): Date Created: 20231006 Date Completed: 20241009 Latest Revision: 20241009
Update Code: 20260130
DOI: 10.1080/14786419.2023.2265039
PMID: 37799112
Βάση Δεδομένων: MEDLINE
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  Data: Anti-diabetic and anti-urease potential of Osbeckia nutans Wall. leaves.
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  Data: <searchLink fieldCode="AU" term="%22Chelleng+N%22">Chelleng N</searchLink>; Natural Product Chemistry Section, CSIR-North East Institute of Science and Technology, Naharlagun, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.<br /><searchLink fieldCode="AU" term="%22Hazarika+M%22">Hazarika M</searchLink>; Natural Product Chemistry Section, CSIR-North East Institute of Science and Technology, Naharlagun, India.<br /><searchLink fieldCode="AU" term="%22Sonia+H%22">Sonia H</searchLink>; Natural Product Chemistry Section, CSIR-North East Institute of Science and Technology, Naharlagun, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.<br /><searchLink fieldCode="AU" term="%22Dihingia+A%22">Dihingia A</searchLink>; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Biological Science & Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, India.<br /><searchLink fieldCode="AU" term="%22Manna+P%22">Manna P</searchLink>; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Biological Science & Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, India.<br /><searchLink fieldCode="AU" term="%22Puzari+M%22">Puzari M</searchLink>; Department of Life Sciences, Dibrugarh University, Dibrugarh, India.<br /><searchLink fieldCode="AU" term="%22Chetia+P%22">Chetia P</searchLink>; Department of Life Sciences, Dibrugarh University, Dibrugarh, India.<br /><searchLink fieldCode="AU" term="%22Tamuly+C%22">Tamuly C</searchLink>; Natural Product Chemistry Section, CSIR-North East Institute of Science and Technology, Naharlagun, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
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  Data: <searchLink fieldCode="JN" term="%22101167924%22">Natural product research</searchLink> [Nat Prod Res] 2024 Nov; Vol. 38 (21), pp. 3870-3875. <i>Date of Electronic Publication: </i>2023 Oct 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis+Health+Sciences%22">Taylor & Francis Health Sciences </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101167924 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1478-6427 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214786419%22">14786419 </searchLink><i>NLM ISO Abbreviation: </i>Nat Prod Res <i>Subsets: </i>MEDLINE
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  Data: <i>Original Publication</i>: Milton Park, UK : Taylor & Francis Health Sciences, c2003-
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  Data: <searchLink fieldCode="MM" term="%22Plant+Leaves%22">Plant Leaves*</searchLink>/<searchLink fieldCode="MM" term="%22Plant+Leaves+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Hypoglycemic+Agents%22">Hypoglycemic Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Hypoglycemic+Agents+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Hypoglycemic+Agents%22">Hypoglycemic Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Hypoglycemic+Agents+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Urease%22">Urease*</searchLink>/<searchLink fieldCode="MM" term="%22Urease+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Plant+Extracts%22">Plant Extracts*</searchLink>/<searchLink fieldCode="MM" term="%22Plant+Extracts+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Plant+Extracts%22">Plant Extracts*</searchLink>/<searchLink fieldCode="MM" term="%22Plant+Extracts+chemistry%22">chemistry</searchLink><br /><searchLink fieldCode="MH" term="%22alpha-Glucosidases%22">alpha-Glucosidases</searchLink>/<searchLink fieldCode="MH" term="%22alpha-Glucosidases+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Flavonoids%22">Flavonoids</searchLink>/<searchLink fieldCode="MH" term="%22Flavonoids+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Flavonoids%22">Flavonoids</searchLink>/<searchLink fieldCode="MH" term="%22Flavonoids+chemistry%22">chemistry</searchLink> ; <searchLink fieldCode="MH" term="%22Glycoside+Hydrolase+Inhibitors%22">Glycoside Hydrolase Inhibitors</searchLink>/<searchLink fieldCode="MH" term="%22Glycoside+Hydrolase+Inhibitors+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Glycoside+Hydrolase+Inhibitors%22">Glycoside Hydrolase Inhibitors</searchLink>/<searchLink fieldCode="MH" term="%22Glycoside+Hydrolase+Inhibitors+chemistry%22">chemistry</searchLink> ; <searchLink fieldCode="MH" term="%22Quercetin%22">Quercetin</searchLink>/<searchLink fieldCode="MH" term="%22Quercetin+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Quercetin%22">Quercetin</searchLink>/<searchLink fieldCode="MH" term="%22Quercetin+chemistry%22">chemistry</searchLink> ; <searchLink fieldCode="MH" term="%22Glucose+Transporter+Type+4%22">Glucose Transporter Type 4</searchLink>/<searchLink fieldCode="MH" term="%22Glucose+Transporter+Type+4+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Helicobacter+pylori%22">Helicobacter pylori</searchLink>/<searchLink fieldCode="MH" term="%22Helicobacter+pylori+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Asteraceae%22">Asteraceae</searchLink>/<searchLink fieldCode="MH" term="%22Asteraceae+chemistry%22">chemistry</searchLink> ; <searchLink fieldCode="MH" term="%22Luteolin%22">Luteolin</searchLink>/<searchLink fieldCode="MH" term="%22Luteolin+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Luteolin%22">Luteolin</searchLink>/<searchLink fieldCode="MH" term="%22Luteolin+chemistry%22">chemistry</searchLink> ; <searchLink fieldCode="MH" term="%22Glucose%22">Glucose</searchLink>/<searchLink fieldCode="MH" term="%22Glucose+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Catechin%22">Catechin</searchLink>/<searchLink fieldCode="MH" term="%22Catechin+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Catechin%22">Catechin</searchLink>/<searchLink fieldCode="MH" term="%22Catechin+chemistry%22">chemistry</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: A study was conducted to investigate the anti-diabetic and anti-urease potential of Osbeckia nutans leaves (ONL). Six compounds, i.e. quercetin-3-O-glucoside, myricetin, shikimic acid, catechin, trans-ferulic acid and luteolin were identified from the butanol sub-fraction, BE2 and the ethyl acetate sub-fraction, EA5 of ONL. BE2 inhibited α-glucosidase and Jack bean urease with IC<subscript>50</subscript> values of 0.036 μg/mL (437.46 μg/mL for acarbose) and 0.327 mg/mL (0.039 mg/mL for thiourea), respectively. In the glucose uptake experiment, BE2 (0.05 mg/mL) treatment resulted in a substantial increase in glucose uptake in free fatty acid (FFA)-treated cells at a concentration 10 times lower than that seen in EA5 (0.5 mg/mL) treated cells. The binding energies of quercetin-3-O-glucoside with α-glucosidase, glucose transporter GLUT4 and H. pylori urease were found to be -94.2585, -219.8271 and -254.391 kcal/mol, respectively. This study revealed that ONL has anti-diabetic and anti-urease abilities and further in-depth research may unveil its full potential.
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>H. pylori urease; Osbeckia nutans; cellular glucose uptake; chemical constituents; molecular docking; α-glucosidase
– Name: NumberCAS
  Label: Substance Nomenclature
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  Data: 0 (Hypoglycemic Agents)<br />EC 3.5.1.5 (Urease)<br />0 (Plant Extracts)<br />EC 3.2.1.20 (alpha-Glucosidases)<br />0 (Flavonoids)<br />0 (Glycoside Hydrolase Inhibitors)<br />9IKM0I5T1E (Quercetin)<br />76XC01FTOJ (myricetin)<br />0 (Glucose Transporter Type 4)<br />KUX1ZNC9J2 (Luteolin)<br />IY9XDZ35W2 (Glucose)<br />8R1V1STN48 (Catechin)
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  Label: Entry Date(s)
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  Data: <i>Date Created: </i>20231006 <i>Date Completed: </i>20241009 <i>Latest Revision: </i>20241009
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  Data: 10.1080/14786419.2023.2265039
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  Data: 37799112
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=37799112
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        Value: 10.1080/14786419.2023.2265039
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 3870
    Subjects:
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        Type: general
      – SubjectFull: Flavonoids pharmacology
        Type: general
      – SubjectFull: Flavonoids chemistry
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      – SubjectFull: Quercetin chemistry
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      – SubjectFull: Glucose Transporter Type 4 metabolism
        Type: general
      – SubjectFull: Helicobacter pylori drug effects
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      – SubjectFull: Asteraceae chemistry
        Type: general
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        Type: general
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      – TitleFull: Anti-diabetic and anti-urease potential of Osbeckia nutans Wall. leaves.
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              Text: 2024 Nov
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