Academic Journal
Preussiate, a new urease inhibitory chalcone from Dioscorea preussii Pax.
| Τίτλος: | Preussiate, a new urease inhibitory chalcone from Dioscorea preussii Pax. |
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| Συγγραφείς: | Ali MS; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan., Iqbal S; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan., Lateef M; Multi-Disciplinary Research Lab, Bahria University, Medical and Dental College, Karachi, Pakistan., Joseph N; Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine, University of Yaounde 1, Yaounde, Cameroon. |
| Πηγή: | Natural product research [Nat Prod Res] 2025 Jan; Vol. 39 (1), pp. 1-8. Date of Electronic Publication: 2023 Aug 21. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| Ιατρικοί όροι (MeSH): | Urease*/antagonists & inhibitors , Antioxidants*/pharmacology , Antioxidants*/chemistry , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Dioscorea*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/isolation & purification, Chalcones/pharmacology ; Chalcones/chemistry ; Chalcones/isolation & purification ; Plant Components, Aerial/chemistry ; Chalcone/chemistry ; Chalcone/pharmacology ; Chalcone/analogs & derivatives ; Molecular Structure ; Inhibitory Concentration 50 ; Magnetic Resonance Spectroscopy |
| Περίληψη: | The phytochemical investigation of the aqueous methanolic extract of the aerial parts of Dioscorea preussii, led to the isolation of a new chalcone preussiate (1) along with 10 other compounds including xanthomicrol (2), cholestan-3-one (3), arjunolic acid (4), tormentic acid (5), ursolic acid (6), betulin (7), lupeol (8), p-hydroxybenzoic acid (9), isovanillin (10) and vanillic acid (11), being reported for the first time from this plant. Their structures were established by spectroscopic techniques including 2D NMR spectroscopy. All the isolates were subjected to the biological screening but only showed antioxidant and urease inhibitory properties. The compounds 1,8 and 11 displayed the most potent urease inhibitory properties with IC |
| Contributed Indexing: | Keywords: Dioscorea preussii; Dioscoreaceae; chalcone; preussiate; urease inhibition |
| Substance Nomenclature: | EC 3.5.1.5 (Urease) 0 (Antioxidants) 0 (Plant Extracts) 0 (Enzyme Inhibitors) 0 (Chalcones) 5S5A2Q39HX (Chalcone) |
| Entry Date(s): | Date Created: 20230821 Date Completed: 20250102 Latest Revision: 20250102 |
| Update Code: | 20260130 |
| DOI: | 10.1080/14786419.2023.2248350 |
| PMID: | 37599618 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1478-6427 |
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| DOI: | 10.1080/14786419.2023.2248350 |