Dynamic Analysis of Aerosol Release from a Pressurized Metered Dose Inhaler Combined with a Valved Holding Chamber Using Simplified Laser Photometry.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Dynamic Analysis of Aerosol Release from a Pressurized Metered Dose Inhaler Combined with a Valved Holding Chamber Using Simplified Laser Photometry.
Συγγραφείς:	Kondo T; Department of Respiratory Medicine, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Japan., Tanigaki T; Department of Respiratory Medicine, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Japan., Hibino M; Department of Respiratory Medicine, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Japan., Tajiri S; Department of Respiratory Medicine, Tokai University Oiso Hospital, Oiso, Japan., Horiuchi S; Department of Respiratory Medicine, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Japan., Maeda K; Department of Respiratory Medicine, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Japan., Tobe S; Department of Respiratory Medicine, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Japan., Kamada R; Department of Respiratory Medicine, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Japan.
Πηγή:	Journal of aerosol medicine and pulmonary drug delivery [J Aerosol Med Pulm Drug Deliv] 2023 Aug; Vol. 36 (4), pp. 181-188. Date of Electronic Publication: 2023 May 22.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101475057 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-2703 (Electronic) Linking ISSN: 19412711 NLM ISO Abbreviation: J Aerosol Med Pulm Drug Deliv
Imprint Name(s):	Original Publication: Rochelle, NY : Mary Ann Liebert, Inc.
Ιατρικοί όροι (MeSH):	Aerosols/analysis , Inhalation Spacers , Metered Dose Inhalers*, Bronchodilator Agents/administration & dosage ; Photometry/methods ; Administration, Inhalation ; Equipment Design ; Pressure ; Lasers
Περίληψη:	Background: A pressurized metered dose inhaler combined with a valved holding chamber (pMDI+VHC) is used to prevent upper airway complications and improve the efficiency of inhaled drug delivery; however, the aerodynamic behavior of the released particles has not been well investigated. This study aimed at clarifying the particle release profiles of a VHC using simplified laser photometry. Methods: An inhalation simulator comprised a computer-controlled pump and a valve system that withdrew aerosol from a pMDI+VHC using a jump-up flow profile. A red laser illuminated the particles leaving VHC and evaluated the intensity of the light reflected by the released particles. Results: The data suggested that the output (OPT) from the laser reflection system represented particle concentration rather than particle mass, and the latter was calculated as OPT × instantaneous withdrawn flow (WF). Summation of OPT hyperbolically decreased with flow increment, whereas summation of OPT × instantaneous flow was not influenced by WF strength. Particle release trajectories consisted of three phases, namely increment with a parabolic curve, flat, and decrement with exponential decay phases. The flat phase appeared exclusively at low-flow withdrawal. These particle release profiles suggest the importance of early phase inhalation. The hyperbolic relationship between WF and particle release time revealed the minimal required withdrawal time at an individual withdrawal strength. Conclusions: The particle release mass was calculated as laser photometric output × instantaneous flow. Simulation of the released particles suggested the importance of early phase inhalation and predicted the minimally required withdrawal time from a pMDI+VHC.
Contributed Indexing:	Keywords: aerosol; laser photometry; pressurized metered dose inhaler; valved holding chamber
Substance Nomenclature:	0 (Aerosols) 0 (Bronchodilator Agents)
Entry Date(s):	Date Created: 20230523 Date Completed: 20231011 Latest Revision: 20250801
Update Code:	20260130
DOI:	10.1089/jamp.2022.0060
PMID:	37219899
Βάση Δεδομένων:	MEDLINE

Περιγραφή
ISSN:	1941-2703
DOI:	10.1089/jamp.2022.0060