Academic Journal
A Case of T-Cell Large Granulocyte Lymphocytic Leukemia in Rheumatoid Arthritis.
| Τίτλος: | A Case of T-Cell Large Granulocyte Lymphocytic Leukemia in Rheumatoid Arthritis. |
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| Συγγραφείς: | Robinson C; Internal Medicine, Henry Ford Health System, Jackson, USA., Ramanan S; Internal Medicine, Henry Ford Health System, Jackson, USA., Singh H; Internal Medicine, Henry Ford Health System, Jackson, USA., Minhas JS; Medicine, St. George's University School of Medicine, St. George's, GRD., Zebda H; Rheumatology, Henry Ford Health System, Detroit, USA. |
| Πηγή: | Cureus [Cureus] 2023 Mar 16; Vol. 15 (3), pp. e36266. Date of Electronic Publication: 2023 Mar 16 (Print Publication: 2023). |
| Τύπος έκδοσης: | Case Reports; Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Palo Alto, CA : Cureus, Inc. |
| Περίληψη: | T-cell large granulocyte lymphocytic (TLGL) leukemia is a lymphoproliferative disorder involving clonal expansion of cytotoxic T-cells and subsequent cytopenia, most notably neutropenia, as well as splenomegaly. TLGL leukemia is commonly associated with autoimmune disorders, most commonly rheumatoid arthritis (RA). We present a case of a 54-year-old female with a past medical history of seropositive RA who was lost to follow-up and thus was not on any active treatment for RA for several years. She returned to the clinic with worsening joint pain, swelling, and stiffness involving multiple joints. Screen laboratory work revealed an absolute neutrophil count (ANC) of 0.19 K/uL, indicating severe neutropenia. This finding prompted further workup, for which our patient was ultimately diagnosed with TLGL leukemia. Proper treatment and control of inflammation in RA are important not only to preserve joint function and vitality but also to prevent rare sequela of untreated autoimmune disorders, as was the case in our patient. (Copyright © 2023, Robinson et al.) |
| Competing Interests: | The authors have declared that no competing interests exist. |
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| Contributed Indexing: | Keywords: flow cytometry; leukemia; lgl leukemia; rheumatoid arthritis; t-cells |
| Entry Date(s): | Date Created: 20230417 Latest Revision: 20230418 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10103792 |
| DOI: | 10.7759/cureus.36266 |
| PMID: | 37065388 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2168-8184 |
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| DOI: | 10.7759/cureus.36266 |