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Cytomegalovirus Infection Is Associated With Adverse Outcomes Among Hospitalized Pediatric Patients With Inflammatory Bowel Disease.

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Τίτλος: Cytomegalovirus Infection Is Associated With Adverse Outcomes Among Hospitalized Pediatric Patients With Inflammatory Bowel Disease.
Συγγραφείς: Thavamani A; Division of Pediatric Gastroenterology, Hepatology and Nutrition, UH Rainbow Babies and Children's Hospital/Case Western Reserve University School of Medicine, Cleveland, OH, USA., Umapathi KK; Division of Pediatric Cardiology, Rush University Medical Center, Chicago, IL, USA., Sferra TJ; Division of Pediatric Gastroenterology, Hepatology and Nutrition, UH Rainbow Babies and Children's Hospital/Case Western Reserve University School of Medicine, Cleveland, OH, USA., Sankararaman S; Division of Pediatric Gastroenterology, Hepatology and Nutrition, UH Rainbow Babies and Children's Hospital/Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Πηγή: Gastroenterology research [Gastroenterology Res] 2023 Feb; Vol. 16 (1), pp. 1-8. Date of Electronic Publication: 2023 Feb 28.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elmer Press Country of Publication: Canada NLM ID: 101519422 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1918-2805 (Print) Linking ISSN: 19182805 NLM ISO Abbreviation: Gastroenterology Res Subsets: PubMed not MEDLINE
Imprint Name(s): Publication: 2009- : Brossard, Québec : Elmer Press
Original Publication: Candiac, Québec : [s.n.]
Περίληψη: Background: Adults with inflammatory bowel disease (IBD) are at increased risk of developing cytomegalovirus (CMV) colitis, which is associated with adverse outcomes. Similar studies in pediatric IBD patients are lacking.
Methods: We analyzed non-overlapping years of National Inpatient Sample (NIS) and Kids Inpatient Database (KID) between 2003 and 2016. We included all patients < 21 years with a diagnosis of Crohn's disease (CD) or ulcerative colitis (UC). Patients with coexisting CMV infection during that admission were compared with patients without CMV infection for outcome measures such as in-hospital mortality, disease severity, and healthcare resource utilization.
Results: We analyzed a total of 254,839 IBD-related hospitalizations. The overall prevalence rate of CMV infection was 0.3% with an overall increasing prevalence trend, P < 0.001. Approximately two-thirds of patients with CMV infection had UC, which was associated with almost 3.6 times increased risk of CMV infection (confidence interval (CI): 3.11 to 4.31, P < 0.001). IBD patients with CMV had more comorbid conditions. CMV infection was significantly associated with increased odds of in-hospital mortality (odds ratio (OR): 3.58; CI: 1.85 to 6.93, P < 0.001) and severe IBD (OR: 3.31; CI: 2.54 to 4.32, P < 0.001). CMV-related IBD hospitalizations had increased length of stay by 9 days while incurring almost $65,000 higher hospitalization charges, P < 0.001.
Conclusions: The prevalence of CMV infection is increasing in pediatric IBD patients. CMV infections significantly corelated with increased risk of mortality and severity of IBD leading to prolonged hospital stay and higher hospitalization charges. Further prospective studies are needed to better understand the factors leading to this increasing CMV infection.
(Copyright 2023, Thavamani et al.)
Competing Interests: Aravind Thavamani, Krishna Kishore Umapathi and Senthilkumar Sankararaman declare no conflict of interest. Thomas J. Sferra is a consultant for Best Doctors INC.
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Contributed Indexing: Keywords: CMV colitis; Crohn’s disease; Cytomegalovirus infection; Health care utilization; Inflammatory bowel disease; Mortality; Population-based study; Ulcerative colitis
Entry Date(s): Date Created: 20230310 Latest Revision: 20230311
Update Code: 20260130
PubMed Central ID: PMC9990534
DOI: 10.14740/gr1588
PMID: 36895701
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1918-2805
DOI:10.14740/gr1588