Academic Journal
Computer Simulation for Effective Pharmaceutical Kinetics and Dynamics: A Review.
| Τίτλος: | Computer Simulation for Effective Pharmaceutical Kinetics and Dynamics: A Review. |
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| Συγγραφείς: | Tiwari G; Department of Pharmaceutical Sciences, PSIT-Pranveer Singh Institute of Technology Pharmacy, Kalpi Road, Bhauti, Kanpur, 208020, Uttar Pradesh, India., Shukla A; Department of Pharmaceutical Sciences, PSIT-Pranveer Singh Institute of Technology Pharmacy, Kalpi Road, Bhauti, Kanpur, 208020, Uttar Pradesh, India., Singh A; Department of Pharmacy, University Institute of Pharmacy, Chhatrapati Shahu Ji Maharaj University (Formerly Kanpur University), Kanpur, 208024, Uttar Pradesh, India., Tiwari R; Department of Pharmaceutical Sciences, PSIT-Pranveer Singh Institute of Technology Pharmacy, Kalpi Road, Bhauti, Kanpur, 208020, Uttar Pradesh, India. |
| Πηγή: | Current computer-aided drug design [Curr Comput Aided Drug Des] 2024; Vol. 20 (4), pp. 325-340. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101265750 Publication Model: Print Cited Medium: Internet ISSN: 1875-6697 (Electronic) Linking ISSN: 15734099 NLM ISO Abbreviation: Curr Comput Aided Drug Des Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, c2005- |
| Ιατρικοί όροι (MeSH): | Computer Simulation* , Pharmacokinetics* , Models, Biological*, Pharmaceutical Preparations/metabolism ; Pharmaceutical Preparations/administration & dosage ; Pharmaceutical Preparations/chemistry ; Humans ; Animals ; Kinetics |
| Περίληψη: | Computer-based modelling and simulation are developing as effective tools for supplementing biological data processing and interpretation. It helps to accelerate the creation of dosage forms at a lower cost and with the less human effort required to conduct the work. This paper aims to provide a comprehensive description of the different computer simulation models for various drugs along with their outcomes. The data used are taken from different sources, including review papers from Science Direct, Elsevier, NCBI, and Web of Science from 1995-2020. Keywords like - pharmacokinetic, pharmacodynamics, computer simulation, whole-cell model, and cell simulation, were used for the search process. The use of computer simulation helps speed up the creation of new dosage forms at a lower cost and less human effort required to complete the work. It is also widely used as a technique for researching the structure and dynamics of lipids and proteins found in membranes. It also facilitates both the diagnosis and prevention of illness. Conventional data analysis methods cannot assess and comprehend the huge amount, size, and complexity of data collected by in vitro, in vivo</i>, and ex vivo</i> experiments. As a result, numerous in silico</i> computational e-resources, databases, and simulation software are employed to determine pharmacokinetic (PK) and pharmacodynamic (PD) parameters for illness management. These techniques aid in the provision of multiscale representations of biological processes, beginning with proteins and genes and progressing through cells, isolated tissues and organs, and the whole organism. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| Contributed Indexing: | Keywords: Computer simulation; cell simulation; pharmaceutical kinetics; pharmacodynamics; pharmacokinetics; whole-cell modeling |
| Substance Nomenclature: | 0 (Pharmaceutical Preparations) |
| Entry Date(s): | Date Created: 20230228 Date Completed: 20260311 Latest Revision: 20260311 |
| Update Code: | 20260312 |
| DOI: | 10.2174/1573409919666230228104901 |
| PMID: | 36852789 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1875-6697 |
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| DOI: | 10.2174/1573409919666230228104901 |