Academic Journal
Neuroecotoxicology: Effects of environmental heavy metal exposure on the brain of African giant rats and the contribution of vanadium to the neuropathology.
| Τίτλος: | Neuroecotoxicology: Effects of environmental heavy metal exposure on the brain of African giant rats and the contribution of vanadium to the neuropathology. |
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| Συγγραφείς: | Usende IL; Department of Veterinary Anatomy, University of Abuja, Nigeria.; Department of Veterinary Anatomy, University of Ibadan, Nigeria., Olopade JO; Department of Veterinary Anatomy, University of Ibadan, Nigeria., Azeez IA; Department of Veterinary Anatomy, University of Jos, Nigeria., Andrioli A; Department of Neurological and Movement Sciences, University of Verona, Italy., Bankole MO; Department of Neurological and Movement Sciences, University of Verona, Italy., Olopade FE; Department of Human Anatomy, College of Medicine, University of Ibadan, Nigeria., Nafady AA; Department of Veterinary Pathology, Electron Microscope Unit, Assuit University, Egypt., Bentivoglio M; Department of Neurological and Movement Sciences, University of Verona, Italy. |
| Πηγή: | IBRO neuroscience reports [IBRO Neurosci Rep] 2022 Aug 30; Vol. 13, pp. 215-234. Date of Electronic Publication: 2022 Aug 30 (Print Publication: 2022). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101775148 Publication Model: eCollection Cited Medium: Internet ISSN: 2667-2421 (Electronic) Linking ISSN: 26672421 NLM ISO Abbreviation: IBRO Neurosci Rep Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Amsterdam] : Elsevier B.V., [2021]- |
| Περίληψη: | Increased exploitation of minerals has led to pollution of confined environments as documented in Nigeria Niger Delta. Information on the effects on brain of such exposure is limited. Due to its exploratory activities, the African giant rat (Cricetomys gambianus) (AGR) provides a unique model for neuroecotoxicological research to determine levels of animal and human exposure to different pollutants. This study aims to unravel neuropathological features of AGR sampled from three agro-ecological zones of Nigeria. Fifteen AGR were sampled according to previously determined data on heavy metal exposure: high vanadium, high lead, and low metals. Eighteen AGR were collected from low metal zone and divided into two groups. Control group received vehicle while SMV exposed group received 3 mg/kg sodium metavanadate (SMV) intraperitoneally for 14days. Brain immunohistochemical analyses were conducted, and ultrastructural changes were studied in experimentally exposed group. Results showed significant loss of tyrosin hydroxylase, parvalbumin, orexin-A and melanin concentration hormone containing neuronal populations in brains obtained from high vanadium and high lead zones and in experimentally intoxicated SMV groups. Similarly, significant decrease numbers of dendritic arborations; extracellular matrix density, perineuronal nets; astrocytes and microglia activations are documented in same groups. Ultrastructural studies revealed mass denudation, cilia loss, disintegration of ependymal layer and intense destructions of myelin sheaths in SMV exposed group. These are the first "neuroecotoxicological" findings in distinct neuronal cells. The implications of these findings are highly relevant for human population living in these areas, not only in Nigeria but also in similarly polluted areas elsewhere in the world. (© 2022 The Authors.) |
| Competing Interests: | The authors declare no conflict of interest. |
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| Contributed Indexing: | Keywords: African giant rats; Agro-ecological zones; Heavy metals; Neuroecotoxicology; Neuronal cell degeneration; Nigeria |
| Entry Date(s): | Date Created: 20230102 Latest Revision: 20230103 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9795313 |
| DOI: | 10.1016/j.ibneur.2022.08.008 |
| PMID: | 36590095 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2667-2421 |
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| DOI: | 10.1016/j.ibneur.2022.08.008 |