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Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review.

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Title: Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review.
Authors: Săndulescu MS; Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; andreea_veliscu@yahoo.com., Văduva CC, Siminel MA, Dijmărescu AL, Vrabie SC, Camen IV, Tache DE, Neamţu SD, Nagy RD, Carp-Velişcu A, Manolea MM
Source: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie [Rom J Morphol Embryol] 2022 Jul-Sep; Vol. 63 (3), pp. 503-510.
Publication Type: Systematic Review; Journal Article
Language: English
Journal Info: Publisher: Editura Academiei Române Country of Publication: Romania NLM ID: 9112454 Publication Model: Print Cited Medium: Internet ISSN: 2066-8279 (Electronic) Linking ISSN: 12200522 NLM ISO Abbreviation: Rom J Morphol Embryol Subsets: MEDLINE
Imprint Name(s): Original Publication: Bucuresti, România : Editura Academiei Române, [1990-
MeSH Terms: COVID-19*/complications , Infertility*, Humans ; Male ; Female ; SARS-CoV-2 ; Pandemics ; COVID-19 Vaccines ; Peptidyl-Dipeptidase A ; Fertility
Abstract: The appearance of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a major obstacle for the performing of current medical activities throughout the world. COVID-19 has affected humanity in many ways, thus causing a great medical, social, economic, and political instability. The aim of this study was to make an analysis of the scientific data obtained by so far to highlight the impact that COVID-19 has had on fertility and assisted reproductive technology (ART). Infection with SARS-CoV-2 alters the normal immune response by local and systemic damage to tissues and organs. After the virus enters the body, the first lesions are produced in the respiratory tract. Extrapulmonary lesions specific to COVID-19 include acute renal lesions/acute kidney damage, hepatocellular lesions, neurological diseases, myocardial dysfunction and arrhythmia, gastrointestinal diseases but also genital impairment. The possible impairment of the male reproductive system is because angiotensin-converting enzyme 2 (ACE2) receptors are in an increased number in the testes, seminiferous duct cells, spermatogonia, Leydig cells and Sertoli cells. Many published studies to date have pointed out that COVID-19 could also affect female fertility and disrupt the functions of the female reproductive system. The theory that this virus can also be transmitted sexually and can cause infertility or testicular damage is supported by the fact that the virus can be isolated in the semen of COVID-19 patients but only during the disease. Choosing the best method of treating infertility during the COVID-19 pandemic is multifactorial, but the risk of infection and compliance with specific ART hygiene protocols must always be considered. Currently, there is no scientific basis regarding the fact that the COVID-19 vaccination would influence fertility.
References: Reprod Biomed Online. 2020 Aug;41(2):157-159. (PMID: 32466995)
Wien Klin Wochenschr. 2021 Sep;133(17-18):966-972. (PMID: 34047837)
Semin Perinatol. 2020 Nov;44(7):151288. (PMID: 33317710)
Hum Reprod. 2020 Dec 1;35(12):2774-2783. (PMID: 32877507)
Rom J Morphol Embryol. 2020 Oct-Dec;61(4):1067-1076. (PMID: 34171056)
J Hum Reprod Sci. 2020 Oct-Dec;13(4):317-322. (PMID: 33627982)
Reprod Biomed Online. 2020 Sep;41(3):543-545. (PMID: 32883426)
Front Med. 2020 Apr;14(2):185-192. (PMID: 32170560)
Biochemistry (Mosc). 2021 Apr;86(4):389-396. (PMID: 33941061)
N Engl J Med. 2020 May 21;382(21):1969-1973. (PMID: 32227757)
Reprod Toxicol. 2021 Jan;99:65-70. (PMID: 33249233)
Rom J Morphol Embryol. 2022 Jan-Mar;63(1):55-59. (PMID: 36074668)
J Assist Reprod Genet. 2020 Oct;37(10):2393-2398. (PMID: 32748306)
Andrology. 2021 Jan;9(1):48-52. (PMID: 32649023)
Fertil Steril. 2020 Jun;113(6):1140-1149. (PMID: 32482250)
Eur Urol Focus. 2020 Sep 15;6(5):1124-1129. (PMID: 32563676)
Reprod Sci. 2022 Jan;29(1):1-6. (PMID: 33415646)
Eur J Obstet Gynecol Reprod Biol. 2021 May;260:154-158. (PMID: 33774596)
Acta Obstet Gynecol Scand. 2020 May;99(5):569-570. (PMID: 32270485)
Reprod Biomed Online. 2020 Dec;41(6):991-997. (PMID: 33032909)
J Assist Reprod Genet. 2020 Nov;37(11):2663-2668. (PMID: 32939662)
Mol Hum Reprod. 2020 Jun 1;26(6):367-373. (PMID: 32365180)
J Assist Reprod Genet. 2021 Feb;38(2):333-341. (PMID: 33400078)
Reprod Biol Endocrinol. 2020 Nov 4;18(1):105. (PMID: 33148264)
Rom J Morphol Embryol. 2022 Jan-Mar;63(1):39-48. (PMID: 36074666)
J Med Virol. 2021 Mar;93(3):1396-1402. (PMID: 33200417)
Andrologia. 2020 Jul;52(6):e13654. (PMID: 32436229)
PLoS One. 2020 Sep 18;15(9):e0239253. (PMID: 32946479)
J Ovarian Res. 2021 Feb 18;14(1):34. (PMID: 33602259)
Front Med (Lausanne). 2021 Jan 13;7:563893. (PMID: 33521006)
JBRA Assist Reprod. 2020 Jul 14;24(3):358-361. (PMID: 32598835)
Ir J Med Sci. 2022 Oct;191(5):2185-2187. (PMID: 34651258)
Int J Environ Res Public Health. 2022 Jan 16;19(2):. (PMID: 35055804)
Urol J. 2021 Aug 04;:. (PMID: 34346045)
Andrologia. 2020 Oct;52(9):e13791. (PMID: 32790205)
Hong Kong Med J. 2021 Apr;27(2):118-126. (PMID: 33853972)
BMJ Open. 2021 Feb 25;11(2):e045524. (PMID: 33632754)
Air Qual Atmos Health. 2020;13(9):1083-1092. (PMID: 32837614)
Front Med (Lausanne). 2021 Mar 19;8:635255. (PMID: 33816526)
Andrology. 2022 Sep;10(6):1016-1022. (PMID: 35713410)
Reprod Biol Endocrinol. 2020 May 13;18(1):45. (PMID: 32404170)
Middle East Fertil Soc J. 2021;26(1):1. (PMID: 33437145)
Neuro Endocrinol Lett. 2017 Feb;38(1):50-58. (PMID: 28456148)
Am J Epidemiol. 2021 May 4;190(5):701-706. (PMID: 33564827)
J Chin Med Assoc. 2020 Oct;83(10):895-897. (PMID: 33009240)
Can Stud Popul. 2021;48(2-3):217-224. (PMID: 34493896)
Rheumatol Int. 2021 Nov;41(11):1885-1894. (PMID: 34455463)
Int J Mol Med. 2020 Jul;46(1):3-16. (PMID: 32377694)
JAMA Netw Open. 2020 May 1;3(5):e208292. (PMID: 32379329)
Reprod Sci. 2021 Oct;28(10):2735-2742. (PMID: 33415647)
Eur Rev Med Pharmacol Sci. 2021 Jan;25(2):1109-1113. (PMID: 33577068)
JBRA Assist Reprod. 2021 Apr 27;25(2):310-313. (PMID: 33507714)
Medicina (Kaunas). 2021 Nov 01;57(11):. (PMID: 34833407)
Discoveries (Craiova). 2021 Jun 30;9(2):e131. (PMID: 34816001)
Reprod Biomed Online. 2020 Aug;41(2):151-153. (PMID: 32553464)
Reprod Biomed Online. 2021 Jan;42(1):260-267. (PMID: 33288478)
Biol Reprod. 2021 Oct 11;105(4):808-821. (PMID: 34159367)
Urol Case Rep. 2020 Nov;33:101349. (PMID: 32835004)
Diagnostics (Basel). 2021 Mar 24;11(4):. (PMID: 33804914)
F S Rev. 2021 Apr;2(2):140-149. (PMID: 33558864)
J Assist Reprod Genet. 2021 Mar;38(3):621-626. (PMID: 33447949)
Substance Nomenclature: 0 (COVID-19 Vaccines)
EC 3.4.15.1 (Peptidyl-Dipeptidase A)
Entry Date(s): Date Created: 20230102 Date Completed: 20230103 Latest Revision: 20240912
Update Code: 20260130
PubMed Central ID: PMC9926143
DOI: 10.47162/RJME.63.3.04
PMID: 36588488
Database: MEDLINE
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  Data: Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review.
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  Data: <searchLink fieldCode="AU" term="%22Săndulescu+MS%22">Săndulescu MS</searchLink>; Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; andreea_veliscu@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Văduva+CC%22">Văduva CC</searchLink><br /><searchLink fieldCode="AU" term="%22Siminel+MA%22">Siminel MA</searchLink><br /><searchLink fieldCode="AU" term="%22Dijmărescu+AL%22">Dijmărescu AL</searchLink><br /><searchLink fieldCode="AU" term="%22Vrabie+SC%22">Vrabie SC</searchLink><br /><searchLink fieldCode="AU" term="%22Camen+IV%22">Camen IV</searchLink><br /><searchLink fieldCode="AU" term="%22Tache+DE%22">Tache DE</searchLink><br /><searchLink fieldCode="AU" term="%22Neamţu+SD%22">Neamţu SD</searchLink><br /><searchLink fieldCode="AU" term="%22Nagy+RD%22">Nagy RD</searchLink><br /><searchLink fieldCode="AU" term="%22Carp-Velişcu+A%22">Carp-Velişcu A</searchLink><br /><searchLink fieldCode="AU" term="%22Manolea+MM%22">Manolea MM</searchLink>
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editura+Academiei+Române%22">Editura Academiei Române </searchLink><i>Country of Publication: </i>Romania <i>NLM ID: </i>9112454 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2066-8279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2212200522%22">12200522 </searchLink><i>NLM ISO Abbreviation: </i>Rom J Morphol Embryol <i>Subsets: </i>MEDLINE
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The appearance of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a major obstacle for the performing of current medical activities throughout the world. COVID-19 has affected humanity in many ways, thus causing a great medical, social, economic, and political instability. The aim of this study was to make an analysis of the scientific data obtained by so far to highlight the impact that COVID-19 has had on fertility and assisted reproductive technology (ART). Infection with SARS-CoV-2 alters the normal immune response by local and systemic damage to tissues and organs. After the virus enters the body, the first lesions are produced in the respiratory tract. Extrapulmonary lesions specific to COVID-19 include acute renal lesions/acute kidney damage, hepatocellular lesions, neurological diseases, myocardial dysfunction and arrhythmia, gastrointestinal diseases but also genital impairment. The possible impairment of the male reproductive system is because angiotensin-converting enzyme 2 (ACE2) receptors are in an increased number in the testes, seminiferous duct cells, spermatogonia, Leydig cells and Sertoli cells. Many published studies to date have pointed out that COVID-19 could also affect female fertility and disrupt the functions of the female reproductive system. The theory that this virus can also be transmitted sexually and can cause infertility or testicular damage is supported by the fact that the virus can be isolated in the semen of COVID-19 patients but only during the disease. Choosing the best method of treating infertility during the COVID-19 pandemic is multifactorial, but the risk of infection and compliance with specific ART hygiene protocols must always be considered. Currently, there is no scientific basis regarding the fact that the COVID-19 vaccination would influence fertility.
– Name: Ref
  Label: References
  Group: RefInfo
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(PMID: <searchLink fieldCode="PM" term="%2232170560%22">32170560)</searchLink><br />Biochemistry (Mosc). 2021 Apr;86(4):389-396. (PMID: <searchLink fieldCode="PM" term="%2233941061%22">33941061)</searchLink><br />N Engl J Med. 2020 May 21;382(21):1969-1973. (PMID: <searchLink fieldCode="PM" term="%2232227757%22">32227757)</searchLink><br />Reprod Toxicol. 2021 Jan;99:65-70. (PMID: <searchLink fieldCode="PM" term="%2233249233%22">33249233)</searchLink><br />Rom J Morphol Embryol. 2022 Jan-Mar;63(1):55-59. (PMID: <searchLink fieldCode="PM" term="%2236074668%22">36074668)</searchLink><br />J Assist Reprod Genet. 2020 Oct;37(10):2393-2398. (PMID: <searchLink fieldCode="PM" term="%2232748306%22">32748306)</searchLink><br />Andrology. 2021 Jan;9(1):48-52. (PMID: <searchLink fieldCode="PM" term="%2232649023%22">32649023)</searchLink><br />Fertil Steril. 2020 Jun;113(6):1140-1149. (PMID: <searchLink fieldCode="PM" term="%2232482250%22">32482250)</searchLink><br />Eur Urol Focus. 2020 Sep 15;6(5):1124-1129. (PMID: <searchLink fieldCode="PM" term="%2232563676%22">32563676)</searchLink><br />Reprod Sci. 2022 Jan;29(1):1-6. (PMID: <searchLink fieldCode="PM" term="%2233415646%22">33415646)</searchLink><br />Eur J Obstet Gynecol Reprod Biol. 2021 May;260:154-158. (PMID: <searchLink fieldCode="PM" term="%2233774596%22">33774596)</searchLink><br />Acta Obstet Gynecol Scand. 2020 May;99(5):569-570. (PMID: <searchLink fieldCode="PM" term="%2232270485%22">32270485)</searchLink><br />Reprod Biomed Online. 2020 Dec;41(6):991-997. (PMID: <searchLink fieldCode="PM" term="%2233032909%22">33032909)</searchLink><br />J Assist Reprod Genet. 2020 Nov;37(11):2663-2668. (PMID: <searchLink fieldCode="PM" term="%2232939662%22">32939662)</searchLink><br />Mol Hum Reprod. 2020 Jun 1;26(6):367-373. (PMID: <searchLink fieldCode="PM" term="%2232365180%22">32365180)</searchLink><br />J Assist Reprod Genet. 2021 Feb;38(2):333-341. (PMID: <searchLink fieldCode="PM" term="%2233400078%22">33400078)</searchLink><br />Reprod Biol Endocrinol. 2020 Nov 4;18(1):105. (PMID: <searchLink fieldCode="PM" term="%2233148264%22">33148264)</searchLink><br />Rom J Morphol Embryol. 2022 Jan-Mar;63(1):39-48. (PMID: <searchLink fieldCode="PM" term="%2236074666%22">36074666)</searchLink><br />J Med Virol. 2021 Mar;93(3):1396-1402. (PMID: <searchLink fieldCode="PM" term="%2233200417%22">33200417)</searchLink><br />Andrologia. 2020 Jul;52(6):e13654. (PMID: <searchLink fieldCode="PM" term="%2232436229%22">32436229)</searchLink><br />PLoS One. 2020 Sep 18;15(9):e0239253. (PMID: <searchLink fieldCode="PM" term="%2232946479%22">32946479)</searchLink><br />J Ovarian Res. 2021 Feb 18;14(1):34. (PMID: <searchLink fieldCode="PM" term="%2233602259%22">33602259)</searchLink><br />Front Med (Lausanne). 2021 Jan 13;7:563893. (PMID: <searchLink fieldCode="PM" term="%2233521006%22">33521006)</searchLink><br />JBRA Assist Reprod. 2020 Jul 14;24(3):358-361. (PMID: <searchLink fieldCode="PM" term="%2232598835%22">32598835)</searchLink><br />Ir J Med Sci. 2022 Oct;191(5):2185-2187. (PMID: <searchLink fieldCode="PM" term="%2234651258%22">34651258)</searchLink><br />Int J Environ Res Public Health. 2022 Jan 16;19(2):. (PMID: <searchLink fieldCode="PM" term="%2235055804%22">35055804)</searchLink><br />Urol J. 2021 Aug 04;:. (PMID: <searchLink fieldCode="PM" term="%2234346045%22">34346045)</searchLink><br />Andrologia. 2020 Oct;52(9):e13791. (PMID: <searchLink fieldCode="PM" term="%2232790205%22">32790205)</searchLink><br />Hong Kong Med J. 2021 Apr;27(2):118-126. (PMID: <searchLink fieldCode="PM" term="%2233853972%22">33853972)</searchLink><br />BMJ Open. 2021 Feb 25;11(2):e045524. (PMID: <searchLink fieldCode="PM" term="%2233632754%22">33632754)</searchLink><br />Air Qual Atmos Health. 2020;13(9):1083-1092. (PMID: <searchLink fieldCode="PM" term="%2232837614%22">32837614)</searchLink><br />Front Med (Lausanne). 2021 Mar 19;8:635255. (PMID: <searchLink fieldCode="PM" term="%2233816526%22">33816526)</searchLink><br />Andrology. 2022 Sep;10(6):1016-1022. (PMID: <searchLink fieldCode="PM" term="%2235713410%22">35713410)</searchLink><br />Reprod Biol Endocrinol. 2020 May 13;18(1):45. (PMID: <searchLink fieldCode="PM" term="%2232404170%22">32404170)</searchLink><br />Middle East Fertil Soc J. 2021;26(1):1. (PMID: <searchLink fieldCode="PM" term="%2233437145%22">33437145)</searchLink><br />Neuro Endocrinol Lett. 2017 Feb;38(1):50-58. (PMID: <searchLink fieldCode="PM" term="%2228456148%22">28456148)</searchLink><br />Am J Epidemiol. 2021 May 4;190(5):701-706. (PMID: <searchLink fieldCode="PM" term="%2233564827%22">33564827)</searchLink><br />J Chin Med Assoc. 2020 Oct;83(10):895-897. (PMID: <searchLink fieldCode="PM" term="%2233009240%22">33009240)</searchLink><br />Can Stud Popul. 2021;48(2-3):217-224. (PMID: <searchLink fieldCode="PM" term="%2234493896%22">34493896)</searchLink><br />Rheumatol Int. 2021 Nov;41(11):1885-1894. (PMID: <searchLink fieldCode="PM" term="%2234455463%22">34455463)</searchLink><br />Int J Mol Med. 2020 Jul;46(1):3-16. (PMID: <searchLink fieldCode="PM" term="%2232377694%22">32377694)</searchLink><br />JAMA Netw Open. 2020 May 1;3(5):e208292. (PMID: <searchLink fieldCode="PM" term="%2232379329%22">32379329)</searchLink><br />Reprod Sci. 2021 Oct;28(10):2735-2742. (PMID: <searchLink fieldCode="PM" term="%2233415647%22">33415647)</searchLink><br />Eur Rev Med Pharmacol Sci. 2021 Jan;25(2):1109-1113. (PMID: <searchLink fieldCode="PM" term="%2233577068%22">33577068)</searchLink><br />JBRA Assist Reprod. 2021 Apr 27;25(2):310-313. (PMID: <searchLink fieldCode="PM" term="%2233507714%22">33507714)</searchLink><br />Medicina (Kaunas). 2021 Nov 01;57(11):. (PMID: <searchLink fieldCode="PM" term="%2234833407%22">34833407)</searchLink><br />Discoveries (Craiova). 2021 Jun 30;9(2):e131. (PMID: <searchLink fieldCode="PM" term="%2234816001%22">34816001)</searchLink><br />Reprod Biomed Online. 2020 Aug;41(2):151-153. (PMID: <searchLink fieldCode="PM" term="%2232553464%22">32553464)</searchLink><br />Reprod Biomed Online. 2021 Jan;42(1):260-267. (PMID: <searchLink fieldCode="PM" term="%2233288478%22">33288478)</searchLink><br />Biol Reprod. 2021 Oct 11;105(4):808-821. (PMID: <searchLink fieldCode="PM" term="%2234159367%22">34159367)</searchLink><br />Urol Case Rep. 2020 Nov;33:101349. (PMID: <searchLink fieldCode="PM" term="%2232835004%22">32835004)</searchLink><br />Diagnostics (Basel). 2021 Mar 24;11(4):. (PMID: <searchLink fieldCode="PM" term="%2233804914%22">33804914)</searchLink><br />F S Rev. 2021 Apr;2(2):140-149. (PMID: <searchLink fieldCode="PM" term="%2233558864%22">33558864)</searchLink><br />J Assist Reprod Genet. 2021 Mar;38(3):621-626. (PMID: <searchLink fieldCode="PM" term="%2233447949%22">33447949)</searchLink>
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        Value: 10.47162/RJME.63.3.04
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        Text: English
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      – SubjectFull: Humans
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      – SubjectFull: COVID-19 Vaccines
        Type: general
      – SubjectFull: Peptidyl-Dipeptidase A
        Type: general
      – SubjectFull: Fertility
        Type: general
      – SubjectFull: COVID-19 complications
        Type: general
      – SubjectFull: Infertility
        Type: general
    Titles:
      – TitleFull: Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Săndulescu MS
      – PersonEntity:
          Name:
            NameFull: Văduva CC
      – PersonEntity:
          Name:
            NameFull: Siminel MA
      – PersonEntity:
          Name:
            NameFull: Dijmărescu AL
      – PersonEntity:
          Name:
            NameFull: Vrabie SC
      – PersonEntity:
          Name:
            NameFull: Camen IV
      – PersonEntity:
          Name:
            NameFull: Tache DE
      – PersonEntity:
          Name:
            NameFull: Neamţu SD
      – PersonEntity:
          Name:
            NameFull: Nagy RD
      – PersonEntity:
          Name:
            NameFull: Carp-Velişcu A
      – PersonEntity:
          Name:
            NameFull: Manolea MM
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: 2022 Jul-Sep
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 2066-8279
          Numbering:
            – Type: volume
              Value: 63
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
              Type: main
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