Academic Journal
Preliminary investigation of a hypertonic saline nasal rinse as a hygienic intervention in dairy workers.
| Τίτλος: | Preliminary investigation of a hypertonic saline nasal rinse as a hygienic intervention in dairy workers. |
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| Συγγραφείς: | Erlandson G; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado., Magzamen S; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado.; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado., Sharp JL; Department of Statistics, Colorado State University, Fort Collins, Colorado., Mitra S; Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado., Jones K; Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado.; Department of Cell Biology, University of Oklahoma Health Science Campus, Oklahoma City, Oklahoma., Poole JA; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska., Bradford M; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado., Nonnenmann M; Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa., Reynolds SJ; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado.; Department of Environmental and Occupational Health, Colorado School of Public Health, Denver, Colorado.; High Plains Intermountain Center for Agricultural Health and Safety, Colorado State University, Fort Collins, Colorado., Schaeffer JW; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado.; Department of Environmental and Occupational Health, Colorado School of Public Health, Denver, Colorado. |
| Πηγή: | Journal of occupational and environmental hygiene [J Occup Environ Hyg] 2023 Jan; Vol. 20 (1), pp. 14-22. Date of Electronic Publication: 2022 Nov 29. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Research Support, U.S. Gov't, Non-P.H.S. |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101189458 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9632 (Electronic) Linking ISSN: 15459624 NLM ISO Abbreviation: J Occup Environ Hyg Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Informa Healthcare Original Publication: Philadelphia, PA : Taylor and Francis, c2004- |
| Ιατρικοί όροι (MeSH): | Interleukin-10* , Interleukin-8*, Dust/prevention & control ; Dust/analysis ; Endotoxins/analysis ; Humans ; Pilot Projects ; Saline Solution, Hypertonic ; Cytokines ; Anti-Inflammatory Agents |
| Περίληψη: | Livestock workers experience an increased burden of bioaerosol-induced respiratory disease including a high prevalence of rhinosinusitis. Dairy operations generate bioaerosols spanning the inhalable size fraction (0-100 μm) containing bacterial constituents such as endotoxin. Particles with an aerodynamic diameter between 10 and 100 μm are known to deposit in the nasopharyngeal region and likely affect the upper respiratory tract. We evaluated the effectiveness of a hypertonic saline nasal lavage in reducing inflammatory responses in dairy workers from a high-volume dairy operation. Inhalable personal breathing zone samples and pre-/post-shift nasal lavage samples from each participant over five consecutive days were collected. The treatment group (n = 5) received hypertonic saline while the control group (n = 5) received normotonic saline. Personal breathing zone samples were analyzed for particulate concentrations and endotoxin using gravimetric and enzymatic methods, respectively. Pro- and anti-inflammatory cytokines (i.e., IL-8, IL-10, and TNF-α) were measured from nasal lavage samples using a multiplex assay. Inhalable dust concentrations ranged from 0.15 to 1.9 mg/m3. Concentrations of both pro- and anti-inflammatory cytokines, specifically IL-6, IL-8, and IL-10, were significantly higher in the treatment group compared to the control group (p < 0.02, p < 0.04, and p < 0.01, respectively). Further analysis of IL-10 anti-inflammatory indicates a positive association between hypertonic saline administration and IL-10 production. This pilot study demonstrates that hypertonic saline nasal lavages were successful in upregulating anti-inflammatory cytokines to support larger interventional studies. |
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| Grant Information: | R01 OH012045 United States OH NIOSH CDC HHS; T42 OH009229 United States OH NIOSH CDC HHS; U01 OH010840 United States OH NIOSH CDC HHS |
| Contributed Indexing: | Keywords: Agricultural health; bioaerosols; cytokines; inflammation; nasal lavage |
| Substance Nomenclature: | 130068-27-8 (Interleukin-10) 0 (Interleukin-8) 0 (Saline Solution, Hypertonic) 0 (Cytokines) 0 (Dust) 0 (Endotoxins) 0 (Anti-Inflammatory Agents) |
| Entry Date(s): | Date Created: 20221019 Date Completed: 20230213 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10958439 |
| DOI: | 10.1080/15459624.2022.2137297 |
| PMID: | 36260509 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1545-9632 |
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| DOI: | 10.1080/15459624.2022.2137297 |