Hydroethanolic Extracts of Senna alata Leaves Possess Antimalarial Effects and Reverses Haematological and Biochemical Pertubation in Plasmodium berghei-infected Mice.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Hydroethanolic Extracts of Senna alata Leaves Possess Antimalarial Effects and Reverses Haematological and Biochemical Pertubation in Plasmodium berghei-infected Mice.
Συγγραφείς:	Atanu FO; Department of Biochemistry, 223207Faculty of Natural Sciences, Kogi State University, Anyigba, Nigeria., Rotimi D; Department of Biochemistry, Faculty of Pure and Applied Sciences, 233773Landmark University, Omu-Aran, Kwara State, Nigeria., Ilesanmi OB; Department of Biochemistry, Faculty of Science, Federal University Otuoke, Yenagoa, Bayelsa State, Nigeria., Al Malki JS; Department of Biology, College of Sciences, 125895Taif University, Taif, Saudi Arabia., Batiha GE; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, 110146Damanhour University, Damanhour, Albeheira, Egypt., Idakwoji PA; Department of Biochemistry, 223207Faculty of Natural Sciences, Kogi State University, Anyigba, Nigeria.
Πηγή:	Journal of evidence-based integrative medicine [J Evid Based Integr Med] 2022 Jan-Dec; Vol. 27, pp. 2515690X221116407.
Τύπος έκδοσης:	Journal Article; Research Support, Non-U.S. Gov't
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: SAGE Publications Country of Publication: United States NLM ID: 101719675 Publication Model: Print Cited Medium: Internet ISSN: 2515-690X (Electronic) Linking ISSN: 2515690X NLM ISO Abbreviation: J Evid Based Integr Med Subsets: MEDLINE
Imprint Name(s):	Original Publication: [Thousand Oaks, CA] : SAGE Publications, [2018]
Ιατρικοί όροι (MeSH):	Antimalarials/pharmacology , Plasmodium berghei, Antioxidants/pharmacology ; Flavonoids/pharmacology ; Parasitemia/drug therapy ; Plant Extracts/therapeutic use ; Plant Leaves/chemistry ; Animals ; Mice
Περίληψη:	The current work investigated the chemical profile, antimalarial potential and capacity of hydroethanolic Senna alata extract (SAE) to reverse hematological and biochemical pertubation in Plasmodium berghei infected mice. Results of the phytochemical analysis revealed the presence of alkaloids, flavonoids, phenolics, tannins, terpenoids, saponins, steroids and cardiac glycosides. Total phenolic and flavonoid content was estimated to be 45.29 ± 2.34 mg GAE/g and 25.22 ± 2.26 mg QE/g respectively. In vitro analysis of the extract also confirmed its antioxidant property. Results of the test for prophylaxis of P. berghei indicated that SAE suppressed parasitemia significantly in treated groups in a dose dependent manner when compared with negative control group. Similarly, SAE improved the mean survival time (MST) and packed cell volume (PCV) of infected mice. The test for curative effect showed that SAE significantly suppressed parasitemia to 4.50 ± 1.05% compared to untreated group 29.83 ± 3.49%. Results of liver and kidney functions indices of treated animals indicated that whereas infection with P. berghei caused increase in the levels of AST, ALT, ALP, urea and creatinine, treatment with SAE significantly reversed the perturbation. Similarly, infected mice were dyslipidemic with concomitant increased activity of HMG CoA reductase and decreased activity of antioxidant enzymes with increase in lipid peroxides levels. However, these alterations were significantly reversed by administration of SAE. Results of this study shows that Senna alata possess antimalarial activity and therefore justify the traditional use of plant for the treatment of malaria.
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Contributed Indexing:	Keywords: Senna alata; lipid metabolism; malaria; parasitemia; plasmodium
Substance Nomenclature:	0 (Antimalarials) 0 (Antioxidants) 0 (Flavonoids) 0 (Plant Extracts)
Entry Date(s):	Date Created: 20220805 Date Completed: 20220808 Latest Revision: 20250728
Update Code:	20260130
PubMed Central ID:	PMC9358563
DOI:	10.1177/2515690X221116407
PMID:	35929106
Βάση Δεδομένων:	MEDLINE

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ISSN:	2515-690X
DOI:	10.1177/2515690X221116407