Academic Journal
Prevalence of Metabolic Syndrome in Young Adults With Congenital Heart Disease.
| Τίτλος: | Prevalence of Metabolic Syndrome in Young Adults With Congenital Heart Disease. |
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| Συγγραφείς: | Umapathi KK; Division of Cardiology, Department of Pediatrics, Rush University Medical Center, Chicago, Illinois. Electronic address: krishnakishoreumapathi@gmail.com., Thavamani A; Department of Pediatrics, Case Western Reserve University Hospital, Cleveland, Ohio., Bosco G; Division of Cardiology, Department of Pediatrics, Rush University Medical Center, Chicago, Illinois., Dhanpalreddy H; Division of Cardiology, Department of Pediatrics, Rush University Medical Center, Chicago, Illinois., Nguyen HH; Department of Pediatrics, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas. |
| Πηγή: | The American journal of cardiology [Am J Cardiol] 2022 Sep 15; Vol. 179, pp. 90-95. Date of Electronic Publication: 2022 Jul 22. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Excerpta Medica Country of Publication: United States NLM ID: 0207277 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1913 (Electronic) Linking ISSN: 00029149 NLM ISO Abbreviation: Am J Cardiol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Excerpta Medica |
| Ιατρικοί όροι (MeSH): | Heart Defects, Congenital* , Metabolic Syndrome*, Adult ; Female ; Humans ; Male ; Prevalence ; Retrospective Studies ; Risk Factors ; United States ; Young Adult |
| Περίληψη: | Adults with congenital heart disease (ACHD) are at risk of developing metabolic syndrome (MetS) at a younger age. We sought to obtain the prevalence of MetS in ACHD from a large population-based database in the United States. We conducted a retrospective cohort study of patients with ACHD in Explorys (IBM Inc., Armonk, New York) database from 2008 to 2019. The ACHD cohort included patients aged 20 to 39 years, with moderate and severe congenital heart disease, as defined by ACHD anatomic and physiologic classification. Patients were diagnosed with MetS using the modified International Diabetes Federation's diagnostic criteria. Logistic regression analysis was performed to compare the risk of MetS in the ACHD cohort. MetS was diagnosed in 1,860 of 6,720 patients with ACHD (27.6%). Among 7,359,470 controls, MetS was seen in 742,010 (10.1%). The average age of MetS in ACHD was 31.5 and 32.7 years in controls (p <0.001). The risk of MetS was higher in ACHD versus controls (odds ratio [OR] 2.75 [2.61 to 2.89], p <0.001). The risk of MetS in ACHD was higher in men (OR 3.01 [2.78 to 3.26], p <0.001) and those aged <25 years (men OR 7.57 [6.31 to 9.07], women OR 4.66 [3.85 to 5.63]; p <0.001). The risk of MetS was higher in patients with severe versus moderate ACHD (OR 1.4 [1.56 to 1.74], p <0.001). In conclusion, MetS and its risk factors are more common in young ACHD than in the general population. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Disclosures The authors have no conflicts of interest to declare. |
| Entry Date(s): | Date Created: 20220725 Date Completed: 20220830 Latest Revision: 20250728 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.amjcard.2022.05.031 |
| PMID: | 35879153 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-1913 |
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| DOI: | 10.1016/j.amjcard.2022.05.031 |