Academic Journal
Neuropeptide Profiles of Mammalian Male Genital Tract: Distribution and Functional Relevance in Reproduction.
| Τίτλος: | Neuropeptide Profiles of Mammalian Male Genital Tract: Distribution and Functional Relevance in Reproduction. |
|---|---|
| Συγγραφείς: | Omirinde JO; Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Jos, Jos, Nigeria., Azeez IA; Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Jos, Jos, Nigeria. |
| Πηγή: | Frontiers in veterinary science [Front Vet Sci] 2022 Mar 30; Vol. 9, pp. 842515. Date of Electronic Publication: 2022 Mar 30 (Print Publication: 2022). |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101666658 Publication Model: eCollection Cited Medium: Print ISSN: 2297-1769 (Print) Linking ISSN: 22971769 NLM ISO Abbreviation: Front Vet Sci Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne : Frontiers Media S.A., [2014]- |
| Περίληψη: | Neuropeptides are secretory peptides characterized by small chains of amino acids linked by peptide bonds. They are majorly found in some mammalian neurons and glial cells, where they modulate a variety of physiological homeostasis. In the male genital tract, they are mostly found in the neuronal fibers supplying the vasculature, smooth muscle layer, interstitium, and lamina propria of the tunica mucosa of the various reproductive organs. Functionally, neuropeptides are strongly implicated in vascular temperature regulations, spermatozoa extrusion, epididymal content transportation, and movement of accessory gland secretions. This review provides an overview of neuropeptides with respect to their synthesis, release, and mechanism of actions, with emphasis on the locally acting neuropeptides, such as substance P (SP), neuropeptide Y (NPY), vasoactive intestinal peptides (VIP), calcitonin gene-related peptide (CGRP), galanin (GAL), cholecystokinin (CCK), C-terminal flanking peptide of NPY (CPON), peptide histidine isoleucine (PHI), and met- and leu-enkephalins (M-ENK and L-ENK) along the male genital tract (i.e., the spermatic cord, testis, epididymis, ductus deferens, and accessory sex organs) of 14 species of mammals and their marked influence on reproduction. This review also revealed from documented reports that the vast majority of neuropeptides present in the autonomic nerve supply to the male genital tract probably coexist with other peptides or with various neurotransmitters (tyrosine hydroxylase, dopamine beta hydroxylase, and 5-hydroxytryptamine). In addition, documented evidence of variation in age, season, and intraspecies differences were identified as notable factors of influence in peptidergic nerve fiber distribution. (Copyright © 2022 Omirinde and Azeez.) |
| Competing Interests: | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: accessory sex glands; male genitalia; mammals; nerve fibers; neuropeptides; reproduction |
| Entry Date(s): | Date Created: 20220418 Latest Revision: 20220507 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9007616 |
| DOI: | 10.3389/fvets.2022.842515 |
| PMID: | 35433909 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2297-1769 |
|---|---|
| DOI: | 10.3389/fvets.2022.842515 |