Academic Journal
The procoagulant status. Hypercoagulability as a risk factor of primary and secondary infertility.
| Τίτλος: | The procoagulant status. Hypercoagulability as a risk factor of primary and secondary infertility. |
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| Συγγραφείς: | Neamţu SD; Department of Legal Medicine, Department of Neonatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania; lillystanca@yahoo.com; mirelasiminel@gmail.com., Stanca L, Siminel MA, Neamţu AV, Gluhovschi A, Mateescu GO, Dijmărescu AL, Săndulescu MS, Istrate-Ofiţeru AM, Trăistaru MR |
| Πηγή: | Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie [Rom J Morphol Embryol] 2021 Jul-Sep; Vol. 62 (3), pp. 829-834. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Editura Academiei Române Country of Publication: Romania NLM ID: 9112454 Publication Model: Print Cited Medium: Internet ISSN: 2066-8279 (Electronic) Linking ISSN: 12200522 NLM ISO Abbreviation: Rom J Morphol Embryol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Bucuresti, România : Editura Academiei Române, [1990- |
| Ιατρικοί όροι (MeSH): | Infertility*/complications , Infertility*/genetics , Thrombophilia*/complications , Thrombosis*/complications, Alleles ; Female ; Humans ; Pregnancy ; Risk Factors |
| Περίληψη: | Thrombophilia is a disorder that makes patients susceptible to intravascular thrombosis that may increase the risk of developing a pregnancy on a known pathology. The female patient diagnosed with hypoplastic uterus and hereditary thrombophilia had a favorable evolution under properly administered anticoagulant treatment. The homozygous status for the C677T mutation may lead to an increase in plasma homocysteine levels, especially in pregnant women, being an associated risk factor for thrombosis. The risk of developing intravascular thrombosis requires primary prevention measures by adding D-dimers in the early diagnostic algorithm, being the most accurate marker of hypercoagulability and endogenous fibrinolysis. The corroboration of the hypercoagulability status with the results of genotyping, the frequencies of the minor/major alleles studied, single mononucleotide polymorphisms (SNPs) and the establishment of preventive therapy, aims to prevent intravascular thrombosis and thromboembolic phenomena. |
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| Entry Date(s): | Date Created: 20220309 Date Completed: 20220311 Latest Revision: 20220716 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9019663 |
| DOI: | 10.47162/RJME.62.3.21 |
| PMID: | 35263412 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2066-8279 |
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| DOI: | 10.47162/RJME.62.3.21 |