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Eye-Tracking Reveals a Role of Oxytocin in Attention Allocation Towards Familiar Faces.

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Τίτλος: Eye-Tracking Reveals a Role of Oxytocin in Attention Allocation Towards Familiar Faces.
Συγγραφείς: Marsh N; Department of Psychiatry, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany., Scheele D; Department of Psychiatry, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.; Department of Psychiatry, University Hospital Bonn, Bonn, Germany., Postin D; Department of Psychiatry, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany., Onken M; Department of Psychiatry, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany., Hurlemann R; Department of Psychiatry, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.; Department of Psychiatry, University Hospital Bonn, Bonn, Germany.; Research Center Neurosensory Science, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Πηγή: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2021 May 17; Vol. 12, pp. 629760. Date of Electronic Publication: 2021 May 17 (Print Publication: 2021).
Τύπος έκδοσης: Journal Article; Randomized Controlled Trial
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
Imprint Name(s): Original Publication: [Lausanne : Frontiers Research Foundation]
Ιατρικοί όροι (MeSH): Eye-Tracking Technology*, Attention/*physiology , Face/*physiology , Oxytocin/*pharmacology , Recognition, Psychology/*physiology, Attention/drug effects ; Autistic Disorder/physiopathology ; Oxytocin/administration & dosage ; Saliva/metabolism ; Administration, Intranasal ; Attitude ; Female ; Humans ; Male ; Personality ; Young Adult
Περίληψη: Visual attention directed towards the eye-region of a face emerges rapidly, even before conscious awareness, and regulates social interactions in terms of approach versus avoidance. Current perspectives on the neuroendocrine substrates of this behavioral regulation highlight a role of the peptide hormone oxytocin (OXT), but it remains unclear whether the facilitating effects of OXT vary as a function of facial familiarity. Here, a total of 73 healthy participants was enrolled in an eye-tracking experiment specifically designed to test whether intranasal OXT (24 IU) augments gaze duration toward the eye-region across four different face categories: the participants' own face, the face of their romantic partner, the face of a familiar person (close friend) or an unfamiliar person (a stranger). We found that OXT treatment induced a tendency to spend more time looking into the eyes of familiar persons (partner and close friend) as compared to placebo. This effect was not evident in the self and unfamiliar conditions. Independent of treatment, volunteers scoring high on autistic-like traits (AQ-high) spent less time looking at the eyes of all faces except their partner. Collectively, our results show that the OXT system is involved in facilitating an attentional bias towards the eye region of familiar faces, which convey safety and support, especially in anxious contexts. In contrast, autistic-like traits were associated with reduced attention to the eye region of a face regardless of familiarity and OXT-treatment.
(Copyright © 2021 Marsh, Scheele, Postin, Onken and Hurlemann.)
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Contributed Indexing: Keywords: autistic-like traits; eye region; eye-tracking; familiar faces; oxytocin; visual attention
Substance Nomenclature: 50-56-6 (Oxytocin)
Entry Date(s): Date Created: 20210603 Date Completed: 20211216 Latest Revision: 20240402
Update Code: 20260130
PubMed Central ID: PMC8165288
DOI: 10.3389/fendo.2021.629760
PMID: 34079520
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1664-2392
DOI:10.3389/fendo.2021.629760