Academic Journal
Bioactive compounds and hepatoprotective effect of Hancornia speciosa gomes fruit juice on acetaminophen-induced hepatotoxicity in vivo.
| Τίτλος: | Bioactive compounds and hepatoprotective effect of Hancornia speciosa gomes fruit juice on acetaminophen-induced hepatotoxicity in vivo. |
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| Συγγραφείς: | Santos RS; Laboratory of Oxidative Stress and Pathologies Associated - LEOPAR, Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil., Chaves-Filho AB; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil., Silva LAS; Laboratory of Oxidative Stress and Pathologies Associated - LEOPAR, Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil., Garcia CAB; Technology and Environmental Monitoring Laboratory - LTMA, Department of Chemistry, Federal University of Sergipe, São Cristovão, Brazil., Silva ARST; Department of Morphology, Federal University of Sergipe, São Cristovão, Brazil., Dolabella SS; Department of Morphology, Federal University of Sergipe, São Cristovão, Brazil., da Costa SSL; Technology and Environmental Monitoring Laboratory - LTMA, Department of Chemistry, Federal University of Sergipe, São Cristovão, Brazil., Miyamoto S; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil., Matos HR; Laboratory of Oxidative Stress and Pathologies Associated - LEOPAR, Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil. |
| Πηγή: | Natural product research [Nat Prod Res] 2022 May; Vol. 36 (10), pp. 2565-2569. Date of Electronic Publication: 2021 Mar 22. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| Ιατρικοί όροι (MeSH): | Apocynaceae*/chemistry , Chemical and Drug Induced Liver Injury*/drug therapy , Chemical and Drug Induced Liver Injury*/prevention & control, Acetaminophen/toxicity ; Antioxidants/pharmacology ; Phenols/pharmacology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Animals ; Fruit and Vegetable Juices ; Liver ; Rats |
| Περίληψη: | Hancornia speciosa Gomes (HS) is a Brazilian fruit tree used in inflammatory disorders by folk medicine. Here we sought to investigate the antioxidant and hepatoprotective properties of HS fruit juice in acetaminophen-induced hepatoxicity model in rats, as well as to perform a comprehensive chemical characterization of phenolics and metals by mass spectrometry. HS showed hepatoprotective and antioxidant activity by decreasing MDA and liver injury markers at healthy control levels. In addition, liver histopathological analysis revealed that HS decreases hepatocellular degeneration. Chemical characterization revealed 16 different phenolics, being chlorogenic acid (150 ± 5 µg/g) and rutin (120 ± 8 µg/g) the major phenolics in HS. Among the 14 micronutrients we identified, zinc and boron were the most abundant metals detected in HS. In line with previous studies involving liver diseases, our data supports evidence that such phenolics and metals present in HS may prevent liver injury induced by acetaminophen. |
| Contributed Indexing: | Keywords: Hancornia speciosa Gomes; acetaminophen; antioxidant; hepatoprotective; mangaba; mass spectrometry; polyphenol |
| Substance Nomenclature: | 0 (Antioxidants) 0 (Phenols) 0 (Plant Extracts) 362O9ITL9D (Acetaminophen) |
| Entry Date(s): | Date Created: 20210322 Date Completed: 20220602 Latest Revision: 20220602 |
| Update Code: | 20260130 |
| DOI: | 10.1080/14786419.2021.1902324 |
| PMID: | 33749461 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1478-6427 |
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| DOI: | 10.1080/14786419.2021.1902324 |