Academic Journal
Maternal toxoplasmosis and the risk of childhood autism: serological and molecular small-scale studies.
| Τίτλος: | Maternal toxoplasmosis and the risk of childhood autism: serological and molecular small-scale studies. |
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| Συγγραφείς: | Al Malki JS; Department of biology, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia., Hussien NA; Department of biology, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia. n.nahed@tu.edu.sa., Al Malki F; Pediatric Department, College of Medicine, Majmaah University, P.O. Box 66, Almajmaah, 11952, Kingdom of Saudi Arabia. |
| Πηγή: | BMC pediatrics [BMC Pediatr] 2021 Mar 17; Vol. 21 (1), pp. 133. Date of Electronic Publication: 2021 Mar 17. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BioMed Central Country of Publication: England NLM ID: 100967804 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2431 (Electronic) Linking ISSN: 14712431 NLM ISO Abbreviation: BMC Pediatr Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2001- |
| Ιατρικοί όροι (MeSH): | Autistic Disorder*/epidemiology , Autistic Disorder*/etiology , Toxoplasma*/genetics , Toxoplasmosis*/complications , Toxoplasmosis*/diagnosis , Toxoplasmosis*/epidemiology, Child ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunoglobulin M ; Pregnancy ; Saudi Arabia |
| Περίληψη: | Background: Toxoplasmosis resulting from infection with the Toxoplasma parasite has become an endemic disease worldwide. Recently, a few studies have reported a high prevalence of Toxoplasmosis infections among Saudi Arabian women. This disease could become life threatening for pregnant women and for immunodeficient people. There is evidence that infections during pregnancy, especially in the early stages, are associated with neurodevelopmental disorders. Autism disorder represents one of the most common neurodevelopmental disorders worldwide; it is associated with delayed language development, weak communication interaction, and repetitive behavior. The relationship between prenatal toxoplasmosis and autism in childhood remains unclear. The present study aims to report a link between maternal toxoplasmosis and autistic offspring among Saudi Arabian women. Method: Blood samples (36 maternal, 36 from their non-autistic children, and 36 from their autistic children) were collected for serological and molecular evaluation. Results: A toxoplasmosis infection was reported for 33.34% of participants using an ELISA assay (5.56% IgG+/IgM+, 11.11% IgG-/IgM+, and 16.67% IgG+/IgM-); however, a nested PCR assay targeting B1 toxoplasmosis specific genes recorded positive tests for 80.56% of the samples. In addition, the present study detected several points of mutation of mtDNA including NADH dehydrogenase (ND1, ND4) and Cyt B genes and the nDNA pyruvate kinase (PK) gene for autistic children infected with toxoplasmosis. Conclusion: Considering previous assumptions, we suggest that a maternal toxoplasmosis infection could have a role in the development of childhood autism linked to mtDNA and nDNA impairment. |
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| Contributed Indexing: | Keywords: Autism; IgG; IgM; Nested PCR; RFLP; Toxoplasmosis |
| Substance Nomenclature: | 0 (Immunoglobulin M) |
| Entry Date(s): | Date Created: 20210318 Date Completed: 20210527 Latest Revision: 20210527 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC7968291 |
| DOI: | 10.1186/s12887-021-02604-4 |
| PMID: | 33731054 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1471-2431 |
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| DOI: | 10.1186/s12887-021-02604-4 |