Academic Journal
DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury.
| Τίτλος: | DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury. |
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| Συγγραφείς: | De Lazzari F; Physiology, Genetics and Behaviour Unit, Department of Biology, University of Padova, 35131, Padova, Italy., Prag HA; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Gruszczyk AV; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Whitworth AJ; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Bisaglia M; Physiology, Genetics and Behaviour Unit, Department of Biology, University of Padova, 35131, Padova, Italy. Electronic address: marco.bisaglia@unipd.it. |
| Πηγή: | Redox biology [Redox Biol] 2021 May; Vol. 41, pp. 101884. Date of Electronic Publication: 2021 Jan 30. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Amsterdam]: Elsevier, B.V., [2013]- |
| Ιατρικοί όροι (MeSH): | Reperfusion Injury*, Animals ; Disease Models, Animal ; Ischemia ; Protein Deglycase DJ-1 ; Reactive Oxygen Species |
| Περίληψη: | DJ-1 is a multifaceted protein with pleiotropic functions that has been implicated in multiple diseases, ranging from neurodegeneration to cancer and ischemia-reperfusion injury. Ischemia is a complex pathological state arising when tissues and organs do not receive adequate levels of oxygen and nutrients. When the blood flow is restored, significant damage occurs over and above that of ischemia alone and is termed ischemia-reperfusion injury. Despite great efforts in the scientific community to ameliorate this pathology, its complex nature has rendered it challenging to obtain satisfactory treatments that translate to the clinic. In this review, we will describe the recent findings on the participation of the protein DJ-1 in the pathophysiology of ischemia-reperfusion injury, firstly introducing the features and functions of DJ-1 and, successively highlighting the therapeutic potential of the protein. (Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| Grant Information: | MC_UU_00015/6 United Kingdom MRC_ Medical Research Council |
| Contributed Indexing: | Keywords: DJ-1; Glucose homeostasis; Ionic balance; Ischemia-reperfusion injury; Mitochondrial homeostasis; Reactive oxygen species |
| Substance Nomenclature: | 0 (Reactive Oxygen Species) EC 3.1.2.- (Protein Deglycase DJ-1) |
| Entry Date(s): | Date Created: 20210209 Date Completed: 20210705 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC7872972 |
| DOI: | 10.1016/j.redox.2021.101884 |
| PMID: | 33561740 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2213-2317 |
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| DOI: | 10.1016/j.redox.2021.101884 |