Academic Journal
Impact of multidrug-resistant tuberculosis and its medications on adverse maternal and perinatal outcomes: protocol for a systematic review and meta-analysis.
| Τίτλος: | Impact of multidrug-resistant tuberculosis and its medications on adverse maternal and perinatal outcomes: protocol for a systematic review and meta-analysis. |
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| Συγγραφείς: | Alene KA; Health Sciences, Curtin University Bentley Campus, Perth, Western Australia, Australia.; College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.; Telethon Kids Institute, Nedlands, Western Australia, Australia., Adane AA; Telethon Kids Institute, Nedlands, Western Australia, Australia., Jegnie A; Agriculture and Environment, The University of Western Australia, Crawley, Western Australia, Australia alemken.jegnie@research.uwa.edu.au. |
| Πηγή: | BMJ open [BMJ Open] 2019 Dec 15; Vol. 9 (12), pp. e034821. Date of Electronic Publication: 2019 Dec 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [London] : BMJ Publishing Group Ltd, 2011- |
| Ιατρικοί όροι (MeSH): | Meta-Analysis as Topic* , Pregnancy Outcome* , Research Design* , Systematic Reviews as Topic*, Pregnancy Complications, Infectious/*drug therapy , Tuberculosis, Multidrug-Resistant/*drug therapy, Female ; Humans ; Infant, Newborn ; Pregnancy |
| Περίληψη: | Introduction: Multidrug-resistant tuberculosis (MDR-TB) is a common public health problem affecting pregnant women. However, the impact of MDR-TB and its medication on pregnancy and perinatal outcomes has been poorly understood and inconsistently reported. Therefore, using the available literature, we aim to determine whether MDR-TB and its medications during pregnancy impact maternal and perinatal outcomes. Methods and Analysis: This systematic review and meta-analysis will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Systematic searches will be conducted in PubMed, Scopus and Web of Science on 10 February 2020 for studies that reported adverse maternal and perinatal outcomes due to MDR-TB and/or its medication. The search will be performed without language and time restrictions. Adverse birth outcomes include miscarriage or abortion, stillbirth, preterm birth, low birth weight, small and large for gestational age, and neonatal death. Two independent reviewers will screen search records, extract data and assess the quality of the studies. The Newcastle-Ottawa Quality Assessment Scale will be used to assess the methodological quality of the included studies. In addition to a narrative synthesis, a random-effects meta-analysis will be conducted when sufficient data are available. I2 statistics will be used to assess the heterogeneity between studies. Ethics and Dissemination: As it will be a systematic review and meta-analysis based on previously published evidence, there will be no requirement for ethical approval. Findings will be published in a peer-reviewed journal and will be presented at various conferences. (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.) |
| Competing Interests: | Competing interests: None declared. |
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| Contributed Indexing: | Keywords: epidemiology; public health; tuberculosis |
| Entry Date(s): | Date Created: 20191218 Date Completed: 20201130 Latest Revision: 20201130 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6924852 |
| DOI: | 10.1136/bmjopen-2019-034821 |
| PMID: | 31843857 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2044-6055 |
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| DOI: | 10.1136/bmjopen-2019-034821 |