Academic Journal
[The role of CTLA-4 in the pathogenesis of chronic tonsillitis].
| Τίτλος: | [The role of CTLA-4 in the pathogenesis of chronic tonsillitis]. |
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| Συγγραφείς: | Zhou CL; Department of Immunology, Allergy and Immunology Research Center, Anhui Medical University, Hefei, 230032, China., Liu YH; Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Anhui Medical University., Da HT; Department of Clinical laboratory, the First Affiliated Hospital of Anhui Medical University., Ang QQ; Department of Immunology, Allergy and Immunology Research Center, Anhui Medical University, Hefei, 230032, China., Sha Q; Department of Immunology, Allergy and Immunology Research Center, Anhui Medical University, Hefei, 230032, China. |
| Πηγή: | Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery [Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi] 2017 Jul 05; Vol. 31 (13), pp. 977-980. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | Chinese |
| Στοιχεία περιοδικού: | Publisher: Lin chuang er bi yan hou tou jing wai ke za zhi bain ji bu Country of Publication: China NLM ID: 101303164 Publication Model: Print Cited Medium: Print ISSN: 2096-7993 (Print) Linking ISSN: 20967993 NLM ISO Abbreviation: Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Wuhan Shi : Lin chuang er bi yan hou tou jing wai ke za zhi bain ji bu |
| Ιατρικοί όροι (MeSH): | CTLA-4 Antigen/*metabolism , Tonsillitis/*immunology, Chronic Disease ; Humans ; Hypertrophy ; Inflammation ; Palatine Tonsil ; Tonsillectomy |
| Περίληψη: | Objective:The purposes of the present study were to explore the role of CTLA-4 in the pathogenesis on development of chronic tonsillitis, and to provide new possibilities and theoretical basis for the drug therapy of chronic tonsillitis and, from soft regulation of the inflammatory immune response point of view. Method:Tonsil tissues were obtained by tonsillectomy and classified into two groups according to clinical forms of tonsillitis, CT (chronic tonsillitis) group (n=21) and TH (hypertrophy of tonsil) group (n=15). We used HE staining to observe the pathological changes in the structure of tonsil tissue in different groups. We used immunofluorescence (IF) method to determine the differences in expression of CTLA-4 between two groups and their distribution characteristics , and used Real-time fluorescent quantitative PCR technique (qRT-PCR) to detect CTLA-4 mRNA expression in the two groups. Result:①HE staining showed the pathogeny structure mainly characterized as the follicular hyperplasia and germinal center in CT group, and obvious "star" phenomenons in TH group. ②Immunofluorescence results showed that the average fluorescence intensity and density of CTLA-4 protein in CT group was significantly higher than in TH group (P<0.05), the difference was statistically significant. ③The qRT-PCR experiment results showed that the expression level of CTLA-4 mRNA in CT group were obviously higher than in HT group (t=6.294, P<0.01), and the differences were statistically significant too. Conclusion:We found CTLA-4 played an important role in the development of chronic tonsillitis disease, suggesting that the mechanism of immunosuppression may exist in the process of chronic tonsil inflammation. Tonsil lymphoid tissue immune suppression provided a new explanation for recurrent tonsillitis, and provides a possibility for the development of new drugs for the treatment of chronic tonsillitis with the exception of surgery recurrent tonsillitis, at the same time for the clinical treatment of chronic tonsillitis in addition to surgery, but the possibility of researching new drugs from the perspective of immunology. (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.) |
| Competing Interests: | The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose. |
| Contributed Indexing: | Keywords: CTLA-4; chronic tonsillitis; immune suppression; immunotherapy |
| Substance Nomenclature: | 0 (CTLA-4 Antigen) |
| Entry Date(s): | Date Created: 20180526 Date Completed: 20181024 Latest Revision: 20181024 |
| Update Code: | 20260130 |
| DOI: | 10.13201/j.issn.1001-1781.2017.13.001 |
| PMID: | 29798156 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2096-7993 |
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| DOI: | 10.13201/j.issn.1001-1781.2017.13.001 |