Academic Journal
Clinical Implementation of a Model-Based In Vivo Dose Verification System for Stereotactic Body Radiation Therapy-Volumetric Modulated Arc Therapy Treatments Using the Electronic Portal Imaging Device.
| Τίτλος: | Clinical Implementation of a Model-Based In Vivo Dose Verification System for Stereotactic Body Radiation Therapy-Volumetric Modulated Arc Therapy Treatments Using the Electronic Portal Imaging Device. |
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| Συγγραφείς: | McCowan PM; Medical Physics Department, CancerCare Manitoba, Winnipeg, Manitoba, Canada. Electronic address: pmccowan@cancercare.mb.ca., Asuni G; Medical Physics Department, CancerCare Manitoba, Winnipeg, Manitoba, Canada., Van Uytven E; Medical Physics Department, CancerCare Manitoba, Winnipeg, Manitoba, Canada; Department of Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba, Canada., VanBeek T; Medical Physics Department, CancerCare Manitoba, Winnipeg, Manitoba, Canada., McCurdy BM; Medical Physics Department, CancerCare Manitoba, Winnipeg, Manitoba, Canada; Department of Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Radiology, University of Manitoba, Winnipeg, Manitoba, Canada., Loewen SK; Department of Oncology, University of Calgary, Calgary, Alberta, Canada., Ahmed N; CancerCare Manitoba, Winnipeg, Manitoba, Canada., Bashir B; CancerCare Manitoba, Winnipeg, Manitoba, Canada., Butler JB; CancerCare Manitoba, Winnipeg, Manitoba, Canada., Chowdhury A; CancerCare Manitoba, Winnipeg, Manitoba, Canada., Dubey A; CancerCare Manitoba, Winnipeg, Manitoba, Canada., Leylek A; CancerCare Manitoba, Winnipeg, Manitoba, Canada., Nashed M; CancerCare Manitoba, Winnipeg, Manitoba, Canada. |
| Πηγή: | International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2017 Apr 01; Vol. 97 (5), pp. 1077-1084. Date of Electronic Publication: 2017 Feb 02. |
| Τύπος έκδοσης: | Clinical Trial; Journal Article; Validation Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 7603616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-355X (Electronic) Linking ISSN: 03603016 NLM ISO Abbreviation: Int J Radiat Oncol Biol Phys Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York, NY : Elsevier, Inc Original Publication: Elmsford, N. Y., Pergamon Press. |
| Ιατρικοί όροι (MeSH): | X-Ray Intensifying Screens*, Neoplasms/*radiotherapy , Radiometry/*instrumentation , Radiosurgery/*instrumentation , Radiotherapy Planning, Computer-Assisted/*methods , Radiotherapy, Intensity-Modulated/*instrumentation, Neoplasms/diagnosis ; Neoplasms/physiopathology ; Radiotherapy Planning, Computer-Assisted/instrumentation ; Radiotherapy, Intensity-Modulated/methods ; Adult ; Aged ; Computer Simulation ; Equipment Design ; Equipment Failure Analysis ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Models, Biological ; Radiotherapy Dosage ; Reproducibility of Results ; Sensitivity and Specificity |
| Περίληψη: | Purpose: To report findings from an in vivo dosimetry program implemented for all stereotactic body radiation therapy patients over a 31-month period and discuss the value and challenges of utilizing in vivo electronic portal imaging device (EPID) dosimetry clinically. Methods and Materials: From December 2013 to July 2016, 117 stereotactic body radiation therapy-volumetric modulated arc therapy patients (100 lung, 15 spine, and 2 liver) underwent 602 EPID-based in vivo dose verification events. A developed model-based dose reconstruction algorithm calculates the 3-dimensional dose distribution to the patient by back-projecting the primary fluence measured by the EPID during treatment. The EPID frame-averaging was optimized in June 2015. For each treatment, a 3%/3-mm γ comparison between our EPID-derived dose and the Eclipse AcurosXB-predicted dose to the planning target volume (PTV) and the ≥20% isodose volume were performed. Alert levels were defined as γ pass rates <85% (lung and liver) and <80% (spine). Investigations were carried out for all fractions exceeding the alert level and were classified as follows: EPID-related, algorithmic, patient setup, anatomic change, or unknown/unidentified errors. Results: The percentages of fractions exceeding the alert levels were 22.6% for lung before frame-average optimization and 8.0% for lung, 20.0% for spine, and 10.0% for liver after frame-average optimization. Overall, mean (± standard deviation) planning target volume γ pass rates were 90.7% ± 9.2%, 87.0% ± 9.3%, and 91.2% ± 3.4% for the lung, spine, and liver patients, respectively. Conclusions: Results from the clinical implementation of our model-based in vivo dose verification method using on-treatment EPID images is reported. The method is demonstrated to be valuable for routine clinical use for verifying delivered dose as well as for detecting errors. (Copyright © 2017 Elsevier Inc. All rights reserved.) |
| Entry Date(s): | Date Created: 20170324 Date Completed: 20170710 Latest Revision: 20191210 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.ijrobp.2017.01.227 |
| PMID: | 28332992 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-355X |
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| DOI: | 10.1016/j.ijrobp.2017.01.227 |