Academic Journal
Clinical Experience and Evaluation of Patient Treatment Verification With a Transit Dosimeter.
| Τίτλος: | Clinical Experience and Evaluation of Patient Treatment Verification With a Transit Dosimeter. |
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| Συγγραφείς: | Ricketts K; Division of Surgery and Interventional Sciences, University College London, London, UK; Department of Radiotherapy Physics, Royal Berkshire NHS Foundation Trust, Reading, UK. Electronic address: k.ricketts@ucl.ac.uk., Navarro C; Department of Radiotherapy Physics, Royal Berkshire NHS Foundation Trust, Reading, UK., Lane K; Department of Radiotherapy Physics, Royal Berkshire NHS Foundation Trust, Reading, UK., Blowfield C; Department of Radiotherapy Physics, Royal Berkshire NHS Foundation Trust, Reading, UK., Cotten G; Department of Radiotherapy Physics, Royal Berkshire NHS Foundation Trust, Reading, UK., Tomala D; Department of Radiotherapy Physics, Royal Berkshire NHS Foundation Trust, Reading, UK., Lord C; Department of Radiotherapy Physics, Royal Berkshire NHS Foundation Trust, Reading, UK., Jones J; Department of Radiotherapy Physics, Royal Berkshire NHS Foundation Trust, Reading, UK., Adeyemi A; Department of Radiotherapy Physics, Royal Berkshire NHS Foundation Trust, Reading, UK. |
| Πηγή: | International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2016 Aug 01; Vol. 95 (5), pp. 1513-1519. Date of Electronic Publication: 2016 Mar 25. |
| Τύπος έκδοσης: | Evaluation Study; Journal Article; Validation Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 7603616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-355X (Electronic) Linking ISSN: 03603016 NLM ISO Abbreviation: Int J Radiat Oncol Biol Phys Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York, NY : Elsevier, Inc Original Publication: Elmsford, N. Y., Pergamon Press. |
| Ιατρικοί όροι (MeSH): | Radiotherapy Dosage* , X-Ray Intensifying Screens*, Neoplasms/*diagnosis , Neoplasms/*radiotherapy , Radiotherapy Planning, Computer-Assisted/*instrumentation, Radiotherapy Planning, Computer-Assisted/methods ; Equipment Design ; Equipment Failure Analysis ; Humans ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity |
| Περίληψη: | Purpose: To prospectively evaluate a protocol for transit dosimetry on a patient population undergoing intensity modulated radiation therapy (IMRT) and to assess the issues in clinical implementation of electronic portal imaging devices (EPIDs) for treatment verification. Methods and Materials: Fifty-eight patients were enrolled in the study. Amorphous silicon EPIDs were calibrated for dose and used to acquire images of delivered fields. Measured EPID dose maps were back-projected using the planning computed tomographic (CT) images to calculate dose at prespecified points within the patient and compared with treatment planning system dose offline using point dose difference and point γ analysis. The deviation of the results was used to inform future action levels. Results: Two hundred twenty-five transit images were analyzed, composed of breast, prostate, and head and neck IMRT fields. Patient measurements demonstrated the potential of the dose verification protocol to model dose well under complex conditions: 83.8% of all delivered beams achieved the initial set tolerance level of ΔD of 0 ± 5 cGy or %ΔD of 0% ± 5%. Importantly, the protocol was also sensitive to anatomic changes and spotted that 3 patients from 20 measured prostate patients had undergone anatomic change in comparison with the planning CT. Patient data suggested an EPID-reconstructed versus treatment planning system dose difference action level of 0% ± 7% for breast fields. Asymmetric action levels were more appropriate for inversed IMRT fields, using absolute dose difference (-2 ± 5 cGy) or summed field percentage dose difference (-6% ± 7%). Conclusions: The in vivo dose verification method was easy to use and simple to implement, and it could detect patient anatomic changes that impacted dose delivery. The system required no extra dose to the patient or treatment time delay and so could be used throughout the course of treatment to identify and limit systematic and random errors in dose delivery for patient groups. (Copyright © 2016 Elsevier Inc. All rights reserved.) |
| Entry Date(s): | Date Created: 20160606 Date Completed: 20170703 Latest Revision: 20191210 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.ijrobp.2016.03.021 |
| PMID: | 27262359 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-355X |
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| DOI: | 10.1016/j.ijrobp.2016.03.021 |