Academic Journal
Maternal lipid levels during pregnancy and gestational diabetes: a systematic review and meta-analysis.
| Τίτλος: | Maternal lipid levels during pregnancy and gestational diabetes: a systematic review and meta-analysis. |
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| Συγγραφείς: | Ryckman KK; Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA., Spracklen CN, Smith CJ, Robinson JG, Saftlas AF |
| Πηγή: | BJOG : an international journal of obstetrics and gynaecology [BJOG] 2015 Apr; Vol. 122 (5), pp. 643-51. Date of Electronic Publication: 2015 Jan 22. |
| Τύπος έκδοσης: | Journal Article; Meta-Analysis; Systematic Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100935741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0528 (Electronic) Linking ISSN: 14700328 NLM ISO Abbreviation: BJOG Subsets: MEDLINE |
| Imprint Name(s): | Publication: Original Publication: Oxford [England] : Blackwell Science, [2000]- |
| Ιατρικοί όροι (MeSH): | Insulin Resistance*, Diabetes, Gestational/*blood , Dyslipidemias/*blood , Lipids/*blood , Triglycerides/*blood, Diabetes, Gestational/metabolism ; Dyslipidemias/metabolism ; Female ; Humans ; Mothers ; Observational Studies as Topic ; Pregnancy ; Pregnancy Trimesters ; Risk Factors |
| Περίληψη: | Background: Lipid levels during pregnancy in women with gestational diabetes mellitus (GDM) have been extensively studied; however, it remains unclear whether dyslipidaemia is a potential marker of preexisting insulin resistance. Objective: To evaluate the relationship between lipid measures throughout pregnancy and GDM. Search Strategy: We searched PubMed-MedLine and SCOPUS (inception until January 2014) and reference lists of relevant studies. Selection Criteria: Publications describing original data with at least one raw lipid (total cholesterol, high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], or triglyceride) measurement during pregnancy in women with GDM and healthy pregnant controls were retained. Data Collection and Analysis: Data extracted from 60 studies were pooled and weighted mean difference (WMD) in lipid levels was calculated using random effects models. Meta-regression was also performed to identify sources of heterogeneity. Main Results: Triglyceride levels were significantly elevated in women with GDM compared with those without GDM (WMD 30.9, 95% confidence interval [95% CI] 25.4-36.4). This finding was consistent in the first, second and third trimesters of pregnancy. HDL-C levels were significantly lower in women with GDM compared with those without GDM in the second (WMD -4.6, 95% CI -6.2 to -3.1) and third (WMD -4.1, 95% CI -6.5 to -1.7) trimesters of pregnancy. There were no differences in aggregate total cholesterol or LDL-C levels between women with GDM and those without insulin resistance. Author's Conclusions: Our meta-analysis shows that triglycerides are significantly elevated among women with GDM compared with women without insulin resistance and this finding persists across all three trimesters of pregnancy. (© 2015 Royal College of Obstetricians and Gynaecologists.) |
| Contributed Indexing: | Keywords: Dyslipidaemia; gestational diabetes mellitus; hypertriglyceridaemia; lipid; pregnancy; triglycerides |
| Substance Nomenclature: | 0 (Lipids) 0 (Triglycerides) |
| Entry Date(s): | Date Created: 20150123 Date Completed: 20150601 Latest Revision: 20250711 |
| Update Code: | 20260130 |
| DOI: | 10.1111/1471-0528.13261 |
| PMID: | 25612005 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1471-0528 |
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| DOI: | 10.1111/1471-0528.13261 |