Silencing urease: a key evolutionary step that facilitated the adaptation of Yersinia pestis to the flea-borne transmission route.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Silencing urease: a key evolutionary step that facilitated the adaptation of Yersinia pestis to the flea-borne transmission route.
Συγγραφείς:	Chouikha I; Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 iman.chouikha@nih.gov., Hinnebusch BJ; Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840.
Πηγή:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Dec 30; Vol. 111 (52), pp. 18709-14. Date of Electronic Publication: 2014 Dec 01.
Τύπος έκδοσης:	Journal Article; Research Support, N.I.H., Intramural
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Imprint Name(s):	Original Publication: Washington, DC : National Academy of Sciences
Ιατρικοί όροι (MeSH):	Bacterial Proteins/genetics , Bacterial Proteins/metabolism , Urease/genetics , Urease/metabolism , Yersinia pestis/enzymology , Yersinia pestis/genetics , Yersinia pestis/pathogenicity , Evolution, Molecular , Gene Silencing, Insect Vectors/microbiology , Xenopsylla/*microbiology, Plague/enzymology ; Plague/genetics ; Plague/pathology ; Plague/transmission ; Yersinia pseudotuberculosis/enzymology ; Yersinia pseudotuberculosis/genetics ; Yersinia pseudotuberculosis/pathogenicity ; Animals ; Humans ; Mutation
Περίληψη:	The arthropod-borne transmission route of Yersinia pestis, the bacterial agent of plague, is a recent evolutionary adaptation. Yersinia pseudotuberculosis, the closely related food-and water-borne enteric species from which Y. pestis diverged less than 6,400 y ago, exhibits significant oral toxicity to the flea vectors of plague, whereas Y. pestis does not. In this study, we identify the Yersinia urease enzyme as the responsible oral toxin. All Y. pestis strains, including those phylogenetically closest to the Y. pseudotuberculosis progenitor, contain a mutated ureD allele that eliminated urease activity. Restoration of a functional ureD was sufficient to make Y. pestis orally toxic to fleas. Conversely, deletion of the urease operon in Y. pseudotuberculosis rendered it nontoxic. Enzymatic activity was required for toxicity. Because urease-related mortality eliminates 30-40% of infective flea vectors, ureD mutation early in the evolution of Y. pestis was likely subject to strong positive selection because it significantly increased transmission potential.
Σχόλια:	Comment in: Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18409-10. doi: 10.1073/pnas.1421887112.. (PMID: 25535337)
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Grant Information:	Z01 AI000796 United States ImNIH Intramural NIH HHS
Contributed Indexing:	Keywords: Yersinia urease; arthropod-borne transmission; evolution; plague; pseudogene
Substance Nomenclature:	0 (Bacterial Proteins) 0 (UreD protein, Bacteria) EC 3.5.1.5 (Urease)
Entry Date(s):	Date Created: 20141203 Date Completed: 20150422 Latest Revision: 20250529
Update Code:	20260130
PubMed Central ID:	PMC4284590
DOI:	10.1073/pnas.1413209111
PMID:	25453069
Βάση Δεδομένων:	MEDLINE

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ISSN:	1091-6490
DOI:	10.1073/pnas.1413209111