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Conserved and host-specific features of influenza virion architecture.

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Title: Conserved and host-specific features of influenza virion architecture.
Authors: Hutchinson EC; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK., Charles PD; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK., Hester SS; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK., Thomas B; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK., Trudgian D; 1] Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK [2]., Martínez-Alonso M; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK., Fodor E; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Source: Nature communications [Nat Commun] 2014 Sep 16; Vol. 5, pp. 4816. Date of Electronic Publication: 2014 Sep 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Language: English
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Imprint Name(s): Original Publication: [London] : Nature Pub. Group
MeSH Terms: Host Specificity/*genetics , Influenza A Virus, H1N1 Subtype/*ultrastructure , Influenza A Virus, H3N2 Subtype/*ultrastructure , Viral Nonstructural Proteins/*genetics , Virion/*ultrastructure, Epithelial Cells/virology ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/growth & development ; Influenza A Virus, H3N2 Subtype/genetics ; Influenza A Virus, H3N2 Subtype/growth & development ; Ovum/virology ; Virion/genetics ; Virion/growth & development ; Amino Acid Sequence ; Animals ; Cattle ; Chickens ; Dogs ; Gene Expression ; Madin Darby Canine Kidney Cells ; Models, Molecular ; Molecular Sequence Data ; Sequence Alignment ; Viral Load
Abstract: Viruses use virions to spread between hosts, and virion composition is therefore the primary determinant of viral transmissibility and immunogenicity. However, the virions of many viruses are complex and pleomorphic, making them difficult to analyse in detail. Here we address this by identifying and quantifying virion proteins with mass spectrometry, producing a complete and quantified model of the hundreds of host-encoded and viral proteins that make up the pleomorphic virions of influenza viruses. We show that a conserved influenza virion architecture is maintained across diverse combinations of virus and host. This 'core' architecture, which includes substantial quantities of host proteins as well as the viral protein NS1, is elaborated with abundant host-dependent features. As a result, influenza virions produced by mammalian and avian hosts have distinct protein compositions. Finally, we note that influenza virions share an underlying protein composition with exosomes, suggesting that influenza virions form by subverting microvesicle production.
Comments: Erratum in: Nat Commun. 2015 Feb 17;6:6446. doi: 10.1038/ncomms7446.. (PMID: 25687574)
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Grant Information: MR/K000241/1 United Kingdom MRC_ Medical Research Council
Contributed Indexing: Indexing Agency: NLM Local ID #: EMS59800.
Substance Nomenclature: 0 (INS1 protein, influenza virus)
0 (Viral Nonstructural Proteins)
Entry Date(s): Date Created: 20140917 Date Completed: 20151030 Latest Revision: 20250529
Update Code: 20260130
PubMed Central ID: PMC4167602
DOI: 10.1038/ncomms5816
PMID: 25226414
Database: MEDLINE
Description
ISSN:2041-1723
DOI:10.1038/ncomms5816