Academic Journal
Immunochemotherapy for cryptosporidiosis in immunosuppressed mouse model.
| Τίτλος: | Immunochemotherapy for cryptosporidiosis in immunosuppressed mouse model. |
|---|---|
| Συγγραφείς: | Sanad MM; Department of Biology, Colleges of Education, Al-Riyadh University for Girls, Saudi Arabia. sand_mm2000@yahoo.com, Al-Malki JS |
| Πηγή: | Journal of the Egyptian Society of Parasitology [J Egypt Soc Parasitol] 2007 Dec; Vol. 37 (3), pp. 945-56. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: The Society] Country of Publication: Egypt NLM ID: 8102141 Publication Model: Print Cited Medium: Print ISSN: 1110-0583 (Print) Linking ISSN: 11100583 NLM ISO Abbreviation: J Egypt Soc Parasitol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Cairo : The Society] |
| Ιατρικοί όροι (MeSH): | Immunocompromised Host* , Immunotherapy*, Cryptosporidiosis/*therapy , Paromomycin/*pharmacology , Thiazoles/*pharmacology, Antiprotozoal Agents/pharmacology ; Cryptosporidiosis/drug therapy ; Interferon-gamma/pharmacology ; Oocysts/drug effects ; Animals ; Disease Models, Animal ; Drug Therapy, Combination ; Humans ; Life Cycle Stages ; Mice ; Nitro Compounds ; Parasite Egg Count ; Random Allocation ; Time Factors ; Treatment Outcome |
| Περίληψη: | Immunochemotherapy as a dual regimen (Nitazoxanide NTZ and Interferon gamma INF-gamma) and a triple one (NTZ, INF-gamma & Paromomycin PRM), administered to immunosuppressed Cryptosporidium infected mice for 10 days (4th-13th day post-infection) was evaluated during and after treatment by determination of parasite count in ileum, associated histopathological changes, oocyst count in Kinyoun's acid fast stained faecal smears, percent reduction in oocyst excretion and cure rate. Both regimens induced nearby efficacy (P > 0.05) with significant reduction in parasite count in the ileum on 7th (P < 0.01) & 14th (P < 0.001) P.I. days, partial regression of histopathological changes and reduction in oocyst count from the 2nd day post-treatment. Oocyst excretion reduction percent was reached zenith on 13th P.I day in both dual (95.76%) and triple (94.86%) regimens (P > 0.05). Complete cure was not achieved. Three days post-treatment relapse occurred in both regimens (P < 0.001) increase in oocyst count (P < 0.01) increase in parasite count in ileum, more severe histopathological changes with rapid deterioration and then, death of all remaining treated mice |
| Substance Nomenclature: | 0 (Antiprotozoal Agents) 0 (Nitro Compounds) 0 (Thiazoles) 61JJC8N5ZK (Paromomycin) 82115-62-6 (Interferon-gamma) SOA12P041N (nitazoxanide) |
| Entry Date(s): | Date Created: 20080404 Date Completed: 20080512 Latest Revision: 20211203 |
| Update Code: | 20260130 |
| PMID: | 18383794 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1110-0583 |
|---|