Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Evaluation of In vitro Anti-cancer Activity of Leaf Extracts of Karañja [Pongamia pinnata (L.) Pierre] and Its In silico Modelling on Drug Targets of Prostate cancer. |
| Συγγραφείς: |
C. S., Surya1, Kumar, N. Manoj2, Kadunganattil, Suraj3, M. V., Bibu John Kariyil4 |
| Πηγή: |
Journal of Chemical Health Risks. 2026, Vol. 16 Issue 4, p2295-2310. 16p. |
| Θεματικοί όροι: |
*Prostate cancer, *Drug target, *Herbal medicine, *Antineoplastic agents, *Millettia pinnata, *Cytotoxins, *Phytochemicals, *Molecular docking |
| Περίληψη: |
Introduction: Prostate cancer ranks as the sixth leading cause of cancer-related deaths in men and the fifth most commonly diagnosed cancer globally, accounting for the loss of approximately 4.04 million healthy life years each year. In Kerala, several traditional Āyurvedic practitioners have long managed cancer cases using single herbal formulations. One such plant, Karañja [Pongamia pinnata (L.) Pierre], has been traditionally employed in cancer therapy, particularly for prostate cancer. Objectives:To evaluate the cytotoxic potential of aqueous and hydroalcoholic leaf extracts of P. pinnata on PC3 prostate cancer cells and to explore the molecular interactions of its active phytoconstituents with key prostate cancer targets through an in-silico approach. Methods: Phytochemical profiling of both extracts was performed using LC--MS/MS analysis, followed by cytotoxicity assessment through MTT assay on PC3 cell lines. Additionally, molecular docking was conducted to evaluate the binding affinities of 10 and 16 ligands identified from hydroalcoholic and aqueous extracts, respectively, against three anticancer targets AR, EGFR, and PIK3CA. Results: The study revealed that both extracts exhibited anticancer activity at specific concentrations, though not statistically significant. Docking studies demonstrated strong binding affinities, particularly between AR and quercetin (-9.33 kcal/mol), EGFR and 21-beta hydroxyhedragenin (-11.97 kcal/mol), and PIK3CA and mangostenone (-10.43 kcal/mol). Conclusions: These findings suggest that the anticancer potential of Pongamia pinnata is closely associated with its rich phytochemical composition, highlighting its promise as a natural candidate for further research in prostate cancer therapeutics. [ABSTRACT FROM AUTHOR] |
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