Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Intra‐apheresis CD34+ cell count: A dynamic approach to predicting peripheral blood stem cell collection yield. |
| Συγγραφείς: |
Alswied, Abdullah1 (AUTHOR), Song, Linda1 (AUTHOR), Thioye‐Sall, Mame1 (AUTHOR), Chen, Leonard N.1 (AUTHOR), West‐Mitchell, Kamille1 (AUTHOR), Zhang, Nan1 (AUTHOR), Jin, Ping1 (AUTHOR), Stroncek, David1 (AUTHOR), Dinh, Anh1 (AUTHOR) anh.dinh@nih.gov |
| Πηγή: |
Transfusion. Jul2026, Vol. 66 Issue 7, p1390-1400. 11p. |
| Θεματικοί όροι: |
*Hematopoietic stem cells, *Blood sampling, *Stem cell donors, *Cytometry, *Regression analysis |
| Περίληψη: |
Background: Accurate prediction of peripheral blood stem cell (PBSC) yield is essential for optimizing hematopoietic stem cell collections. Traditional CD34+ prediction formulas often overlook the ongoing recruitment of CD34+ cells during the collection procedure. This study evaluated whether a single intra‐apheresis CD34+ measurement could improve yield prediction compared to existing prediction models. Methods: We retrospectively analyzed 150 PBSC collections from 123 autologous and allogenic donors. A single intraprocedural CD34+ measurement and final collection yield were obtained, and univariable and multivariable linear regressions were developed to assess predictive accuracy. Model stability and generalizability were tested via bootstrap resampling and cross‐validation. Subgroup analyses by age, sex, weight, diagnosis, and sampling time were performed to confirm robustness. We also compared our results against published pre‐apheresis formulas. Results: Intra‐apheresis CD34+ counts showed a strong correlation with the final yield (r = 0.97; R2 = 0.95). Subgroup analyses across donor demographics and clinical factors yielded similarly high R2 values (0.91–0.99). Multivariable analysis identified intra‐apheresis CD34+ measurement as the primary contributor (β = 0.67, p <.0001). Later sampling (≥1.20 of total blood volumes processed) reduced error metrics relative to earlier draws. Compared to pre‐apheresis models, the intra‐apheresis approach achieved higher R2 and lower error metrics. Discussion: A single intra‐apheresis CD34+ measurement, particularly at or beyond 1.20 processed blood volumes, offers a reliable, real‐time predictor of final PBSC yield. This intraprocedural approach outperforms published pre‐apheresis formulas, enabling more efficient collection and reduced donor burden across diverse clinical scenarios. [ABSTRACT FROM AUTHOR] |
| Βάση Δεδομένων: |
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