Dissertation/ Thesis
Προβολή σε EDS

Structural basis of the early exocytosis : a spatio-temporal model of the vesicle tethering machinery

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Structural basis of the early exocytosis : a spatio-temporal model of the vesicle tethering machinery
Συγγραφείς: Chinchilla Hernández, Altaïr
Συνεισφορές: University/Department: Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida
Thesis Advisors: Gallego, Oriol, Oliva Miguel, Baldo
Πηγή: TDX (Tesis Doctorals en Xarxa)
Στοιχεία εκδότη: Universitat Pompeu Fabra, 2025.
Έτος έκδοσης: 2025
Φυσική περιγραφή: 226 p.
Θεματικοί όροι: Modelaje integrativo, IMP, PICT, PyF2F, Exocitosis, Exocyst, Mso1, Anclaje vesicular, Microscopía de fluorescencia, Integrative modeling, Exocytosis, Vesicle tethering, Fluorescence microscopy
Περιγραφή: El proyecto tiene como objetivo general descifrar el mecanismo de la exocitosis utilizando biología estructural integrativa, lo cual ayudará a entender cómo las células controlan su crecimiento. Para ello, planteamos generar un modelo cuantitativo de la exocitosis con IMP (Integrative Modeling Platform), un software que nos permite combinar 1) datos de la estructura de las proteínas que participan en el proceso de la exocitosis, 2) datos temporales y 3) datos espaciales, para reconstruir un modelo 3D de la distribución espacial y temporal de las proteínas. Este modelo nos ayudará a entender cómo se coordina la maquinaria celular durante el proceso de la exocitosis, así como a diseñar nuevos experimentos que validen nuestras hipótesis.
Description (Translated): The project’s overarching goal is to decipher the mechanism of exocytosis using integrative structural biology, which will help to understand how cells control their growth. To achieve this, we aim to develop a quantitative model of exocytosis using IMP (Integrative Modeling Platform), a software that allows us to combine: 1) structural data of the proteins involved in the exocytosis process, 2) temporal data, and 3) spatial data, to reconstruct a 3D model of the spatial and temporal distribution of these proteins. This model will help us understand how the cellular machinery is coordinated during the exocytosis process and design new experiments to validate our hypotheses.
Programa de Doctorat en Biomedicina
Τύπος εγγράφου: Dissertation/Thesis
Περιγραφή αρχείου: application/pdf
Γλώσσα: English
Σύνδεσμος πρόσβασης: http://hdl.handle.net/10803/694328
Rights: L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/embargoedAccess
Αριθμός Καταχώρησης: edstdx.10803.694328
Βάση Δεδομένων: TDX
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  – Url: http://hdl.handle.net/10803/694328#
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  Data: Structural basis of the early exocytosis : a spatio-temporal model of the vesicle tethering machinery
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  Data: <searchLink fieldCode="AR" term="%22Chinchilla+Hernández%2C+Altaïr%22">Chinchilla Hernández, Altaïr</searchLink>
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  Data: University/Department: Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida
– Name: Author
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  Data: Gallego, Oriol<br />Oliva Miguel, Baldo
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  Data: TDX (Tesis Doctorals en Xarxa)
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  Data: Universitat Pompeu Fabra, 2025.
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  Data: 2025
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  Data: 226 p.
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  Data: <searchLink fieldCode="DE" term="%22Modelaje+integrativo%22">Modelaje integrativo</searchLink><br /><searchLink fieldCode="DE" term="%22IMP%22">IMP</searchLink><br /><searchLink fieldCode="DE" term="%22PICT%22">PICT</searchLink><br /><searchLink fieldCode="DE" term="%22PyF2F%22">PyF2F</searchLink><br /><searchLink fieldCode="DE" term="%22Exocitosis%22">Exocitosis</searchLink><br /><searchLink fieldCode="DE" term="%22Exocyst%22">Exocyst</searchLink><br /><searchLink fieldCode="DE" term="%22Mso1%22">Mso1</searchLink><br /><searchLink fieldCode="DE" term="%22Anclaje+vesicular%22">Anclaje vesicular</searchLink><br /><searchLink fieldCode="DE" term="%22Microscopía+de+fluorescencia%22">Microscopía de fluorescencia</searchLink><br /><searchLink fieldCode="DE" term="%22Integrative+modeling%22">Integrative modeling</searchLink><br /><searchLink fieldCode="DE" term="%22Exocytosis%22">Exocytosis</searchLink><br /><searchLink fieldCode="DE" term="%22Vesicle+tethering%22">Vesicle tethering</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorescence+microscopy%22">Fluorescence microscopy</searchLink>
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  Data: El proyecto tiene como objetivo general descifrar el mecanismo de la exocitosis utilizando biología estructural integrativa, lo cual ayudará a entender cómo las células controlan su crecimiento. Para ello, planteamos generar un modelo cuantitativo de la exocitosis con IMP (Integrative Modeling Platform), un software que nos permite combinar 1) datos de la estructura de las proteínas que participan en el proceso de la exocitosis, 2) datos temporales y 3) datos espaciales, para reconstruir un modelo 3D de la distribución espacial y temporal de las proteínas. Este modelo nos ayudará a entender cómo se coordina la maquinaria celular durante el proceso de la exocitosis, así como a diseñar nuevos experimentos que validen nuestras hipótesis.
– Name: Abstract
  Label: Description (Translated)
  Group: Ab
  Data: The project’s overarching goal is to decipher the mechanism of exocytosis using integrative structural biology, which will help to understand how cells control their growth. To achieve this, we aim to develop a quantitative model of exocytosis using IMP (Integrative Modeling Platform), a software that allows us to combine: 1) structural data of the proteins involved in the exocytosis process, 2) temporal data, and 3) spatial data, to reconstruct a 3D model of the spatial and temporal distribution of these proteins. This model will help us understand how the cellular machinery is coordinated during the exocytosis process and design new experiments to validate our hypotheses.<br />Programa de Doctorat en Biomedicina
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  Data: L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc/4.0/<br />info:eu-repo/semantics/embargoedAccess
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RecordInfo BibRecord:
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      – Text: English
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      Pagination:
        PageCount: 226
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      – SubjectFull: Modelaje integrativo
        Type: general
      – SubjectFull: IMP
        Type: general
      – SubjectFull: PICT
        Type: general
      – SubjectFull: PyF2F
        Type: general
      – SubjectFull: Exocitosis
        Type: general
      – SubjectFull: Exocyst
        Type: general
      – SubjectFull: Mso1
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      – SubjectFull: Anclaje vesicular
        Type: general
      – SubjectFull: Microscopía de fluorescencia
        Type: general
      – SubjectFull: Integrative modeling
        Type: general
      – SubjectFull: Exocytosis
        Type: general
      – SubjectFull: Vesicle tethering
        Type: general
      – SubjectFull: Fluorescence microscopy
        Type: general
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      – TitleFull: Structural basis of the early exocytosis : a spatio-temporal model of the vesicle tethering machinery
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            – D: 24
              M: 03
              Type: published
              Y: 2025
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