Mixed Materials
2D DOSY NMR: A Valuable Tool to Confirm the Complexation in Drug Delivery Systems
| Τίτλος: | 2D DOSY NMR: A Valuable Tool to Confirm the Complexation in Drug Delivery Systems |
|---|---|
| Additional Titles: | Many bioactive substances face the problem of limited bioavailability, mainly due to low aqueous solubility and poor metabolic stability. Their complexation with drug delivery systems offers a more optimum pharmacological profile. Some of these drug delivery systems that have promising potential form complexes with bioactive compounds such as cyclodextrins and calixarenes. The monitoring of the success and the type of the complexation are of great importance and two-dimensional diffusion-ordered NMR spectroscopy (2D DOSY) is a valuable tool for the studying of these complexes and described as “NMR chromatography.” Herein we report the procedure for the complexation of the natural product quercetin in 2-hydroxypropyl-β-cyclodextrin and the anticancer drug temozolomide in p-sulfonatocalix[4]arene and the determination of the complexation with 2D DOSY spectroscopy. © 2021, Springer Science+Business Media, LLC, part of Springer Nature. |
| Συγγραφείς: | Chatzigiannis, C.M., Kiriakidi, S., Tzakos, A.G., Mavromoustakos, T. |
| Στοιχεία εκδότη: | 2021 |
| Τύπος εγγράφου: | Mixed materials |
| Όροι ευρετηρίου: | scientific_publication_article, Scientific publication - Journal Article |
| Σύνδεσμος: | |
| Διαθεσιμότητα: | Open access content. Open access content Creative Commons Attribution-NonCommercial 4.0 (CC-BY-NC) |
| Σημείωση: | English |
| Other Numbers: | GRNKU oai:lib.uoa.gr:uoadl:3076777 uoadl:3076777 1478885574 |
| Πηγή συνεισφοράς: | NATIONAL & KAPODISTRIAN UNIV OF ATHENS From OAIster®, provided by the OCLC Cooperative. |
| Αριθμός Καταχώρησης: | edsoai.on1478885574 |
| Βάση Δεδομένων: | OAIster |
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