Mixed Materials
Distinctive features of pancreatic neuroendocrine neoplasms exhibiting an increment in proliferative activity during the course of the disease
| Τίτλος: | Distinctive features of pancreatic neuroendocrine neoplasms exhibiting an increment in proliferative activity during the course of the disease |
|---|---|
| Additional Titles: | Purpose: Neuroendocrine neoplasms (NENs) differ in their biological behavior and growth potential in a way that can be predicted using histological classification and grading systems. A subset of pancreatic NENs (pNENs) may develop a more aggressive phenotype during the course of the disease, associated with an increase in the Ki-67 proliferation index (PI). The purpose of the study was to present the clinical characteristics of these patients. Methods: Using re-biopsy of growing lesions, we investigated the increase in Ki-67 PI sufficient to change initial grading (G). Results: Of 264 patients with well differentiated (WD) pNENs who showed progressive disease during follow-up, 15 (6%) exhibited an increase in Ki-67 PI at a median time 36.8 (9.3–255.8) months. All neoplasms had WD-morphology: five had G1 (Ki-67 median value 1%), nine G2 (median value 5%), one G3 (25%) grades. Upon change of Ki-67 PI, 3 patients had G2 (8%) and 12 G3 (57.5%) NENs, while all retained their WD-morphology. At last follow-up, eight patients were alive with a median overall survival (OS) of 52.5 (9.5–264.3) months. Μedian OS was shorter in patients who had a change in Ki-67 PI before 36 months compared to those who had a change of Ki-67 PI at a later stage (27.5 95%CI: 11.88–43.06 vs. 120.87 95%CI: 96.05–145.69; log-rank p = 0.018). Conclusions: During the course of their disease, 6% patients with progressive pNENs develop an increase in Ki-67 PI resulting in an increase in grading status while maintaining their morphology. This process is associated with worse OS when it occurs at an early stage. © 2020, Springer Science+Business Media, LLC, part of Springer Nature. |
| Συγγραφείς: | Alexandraki, K.I., Kaltsatou, M., Kyriakopoulos, G., Mavroeidi, V., Kostopoulou, A., Atlan, K., Theocharis, S., Rindi, G., Grossman, A.B., Grozinsky-Glasberg, S., Kaltsas, G.A. |
| Στοιχεία εκδότη: | 2021 |
| Τύπος εγγράφου: | Mixed materials |
| Όροι ευρετηρίου: | scientific_publication_article, Scientific publication - Journal Article |
| Σύνδεσμος: | |
| Διαθεσιμότητα: | Open access content. Open access content Creative Commons Attribution-NonCommercial 4.0 (CC-BY-NC) |
| Σημείωση: | English |
| Other Numbers: | GRNKU oai:lib.uoa.gr:uoadl:3076377 uoadl:3076377 1478876362 |
| Πηγή συνεισφοράς: | NATIONAL & KAPODISTRIAN UNIV OF ATHENS From OAIster®, provided by the OCLC Cooperative. |
| Αριθμός Καταχώρησης: | edsoai.on1478876362 |
| Βάση Δεδομένων: | OAIster |
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