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Development of Innovative Drugs Via Modeling with MATLAB

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Τίτλος: Development of Innovative Drugs Via Modeling with MATLAB
Περιγραφή: The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens? Written from the industry perspective and based on many years of experience, this book offers:- Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs- Guidance for exploration and modification of these programs to enhance the understanding of key principles- Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature- A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling.Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.
Συγγραφείς: Ronald Gieschke, Daniel Serafin
Resource Type: eBook.
Θέματα: Computer simulation, Mathematical models, Drug development--Computer simulation, Digital computer simulation, Pharmaceutical chemistry, Drugs--Design
Categories: MEDICAL / Pharmacology, COMPUTERS / Computer Simulation, MEDICAL / Pharmacy, SCIENCE / Life Sciences / Biology, SCIENCE / Chemistry / Organic, SCIENCE / Research & Methodology
Βάση Δεδομένων: eBook Index
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  Availability: 0
Header DbId: edsebk
DbLabel: eBook Index
An: 670663
RelevancyScore: 912
AccessLevel: 6
PubType: eBook
PubTypeId: ebook
PreciseRelevancyScore: 912.106750488281
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  Data: The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens? Written from the industry perspective and based on many years of experience, this book offers:- Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs- Guidance for exploration and modification of these programs to enhance the understanding of key principles- Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature- A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling.Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.
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      – Code: 615.1900113
        Scheme: ddc
        Type: prePub
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Computer simulation
        Type: general
      – SubjectFull: Mathematical models
        Type: general
      – SubjectFull: Drug development--Computer simulation
        Type: general
      – SubjectFull: Digital computer simulation
        Type: general
      – SubjectFull: Pharmaceutical chemistry
        Type: general
      – SubjectFull: Drugs--Design
        Type: general
    Titles:
      – TitleFull: Development of Innovative Drugs Via Modeling with MATLAB
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          Name:
            NameFull: Ronald Gieschke
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            NameFull: Daniel Serafin
      – PersonEntity:
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            NameFull: Ronald Gieschke
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            NameFull: Daniel Serafin
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          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2014
            – D: 27
              M: 02
              Type: profile
              Y: 2014
          Identifiers:
            – Type: isbn-print
              Value: 9783642397646
            – Type: isbn-electronic
              Value: 9783642397653
          Titles:
            – TitleFull: Development of Innovative Drugs Via Modeling with MATLAB
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