Bibliographic Details
| Title: |
Synthesis of Zinc(II)-natural zeolite mordenite type as a drug carrier for ibuprofen: Drug release kinetic modeling and cytotoxicity study |
| Authors: |
Yantus A.B. Neolaka, Yosep Lawa, Magdarita Riwu, Handoko Darmokoesoemo, Harsasi Setyawati, Johnson Naat, Bernadeta Ayu Widyaningrum, Uyiosa Osagie Aigbe, Kingsley Eghonghon Ukhurebor, Robert Birundu Onyancha, Heri Septya Kusuma |
| Source: |
Results in Chemistry, Vol 4, Iss , Pp 100578- (2022) |
| Publisher Information: |
Elsevier, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Chemistry |
| Subject Terms: |
Ibuprofen, Drug Carrier, Mordenite, Drug Safety, Zn(II), Chemistry, QD1-999 |
| Description: |
Zn(II)-ZMT material development based on natural zeolite mordenite type (ZMT) as a drug carrier for ibuprofen has been explored and assessed. The ion exchange method was carried out to prepare Zn(II)-ZMT material. XRD, FTIR, and FESEM-EDS were used to characterize the physico-chemical characteristics of all materials. The performance of Zn(II)-ZMT as a drug delivery agent for ibuprofen was also evaluated using drug loading-release, zeta potential measurement, and cytotoxicity testing. Six kinetic models (including the zero-order, first-order, Peppas-Sahlin, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas models) were utilized to simulate the drug release process. Meanwhile, a microtetrazolium (MTT) assay was used to analyze the material's cytotoxicity. The Zn(II)-ZMT material has a drug loading content (DLC) of 90.37 % and an efficiency entrapment content (EEC) of 54.22 %, according to drug loading. The drug releases kinetic modeling of Ibuprofen from Zn(II)-ZMT followed the Hixson-Crowell model. This material exhibits good biocompatibility based on a cytotoxicity test using the MTT assay. Ibu@Zn(II)-ZMT has a zeta potential of − 61.55 mV ± 0.1 mV. These findings suggest that the material in the dispersion system has a high degree of stability, indicating that it will not flocculate or coagulate in the body. Furthermore, Zn(II)-ZMT is an inorganic substance that has the potential to be employed as a medication delivery material in the future. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2211-7156 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2211715622002971; https://doaj.org/toc/2211-7156 |
| DOI: |
10.1016/j.rechem.2022.100578 |
| Access URL: |
https://doaj.org/article/ff71751c041b427dadebdaa18e70c1b9 |
| Accession Number: |
edsdoj.ff71751c041b427dadebdaa18e70c1b9 |
| Database: |
Directory of Open Access Journals |