Academic Journal
View in EDS

Hemoglobin-Albumin-Lymphocyte-Platelet Score as an Integrative Biomarker for Prognosis and Sarcopenia in Colorectal Cancer

Bibliographic Details
Title: Hemoglobin-Albumin-Lymphocyte-Platelet Score as an Integrative Biomarker for Prognosis and Sarcopenia in Colorectal Cancer
Authors: Xie H, Wei L, Tang S, Gan J
Source: Journal of Inflammation Research, Vol 18, Iss Issue 1, Pp 14709-14720 (2025)
Publisher Information: Dove Medical Press, 2025.
Publication Year: 2025
Collection: LCC:Pathology
LCC:Therapeutics. Pharmacology
Subject Terms: Colorectal cancer, HALP score, Progression-free survival, Overall survival, Sarcopenia, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Description: Hailun Xie,1,2,* Lishuang Wei,3,* Shuangyi Tang,4 Jialiang Gan2,5 1Department of Gastrointestinal and Gland Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 2Guangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, Nanning, Guangxi, People’s Republic of China; 3Department of Geriatric Respiratory Disease Ward, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 4Department of Pharmacy, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 5Department of Colorectal and Anal Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuangyi Tang, Department of Pharmacy, the First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, 530021, People’s Republic of China, Email tshy369@sina.com Jialiang Gan, Department of Colorectal and Anal Surgery, the First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, 530021, People’s Republic of China, Tel +86-13878155172, Email gjl5172@163.comObjective: This study aimed to comprehensively investigate the dose-response relationship between the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) score, which reflects the combined inflammatory and nutritional status, and progression-free survival (PFS), overall survival (OS), as well as sarcopenia in patients with colorectal cancer (CRC).Methods: A retrospective analysis was conducted on 1,441 CRC patients who underwent surgery. HALP score was calculated as Hemoglobin (g/L) × Albumin (g/L) × Lymphocyte count (109/L) / Platelet count (109/L). Survival analysis was carried out using Kaplan - Meier curves and Cox regression analysis. Logistic regression analysis was employed to analyze the relationship between the HALP and sarcopenia. HALP - based nomograms were developed to predict 1 - and 5 - year PFS and OS.Results: Kaplan - Meier analysis showed that patients with low HALP scores had worse PFS (51.2% vs 63.3%, p < 0.001) and OS (54.1% vs 66.0%, p < 0.001). For every standard deviation increase in HALP scores, the HR for PFS decreased by 13.3% (HR = 0.867, 95% CI = 0.780– 0.963, p = 0.008), and for OS by 15.2% (HR = 0.848, 95% CI = 0.759– 0.948, p = 0.004). Multivariate Cox regression analysis confirmed HALP as an independent prognostic factor for PFS and OS. Logistic regression analysis indicated that low HALP scores were an independent predictor of sarcopenia (OR = 0.550, 95% CI = 0.420– 0.963, p < 0.001). The HALP-based nomograms demonstrated strong predictive performance for prognosis, with C-indexes of 0.726 (PFS) and 0.728 (OS) and 5-year AUCs exceeding 0.76.Conclusion: Low HALP scores are independent risk factors for PFS, OS, and sarcopenia in CRC patients, highlighting HALP’s potential for clinical application in CRC management and may thus assist in personalized treatment decisions.Keywords: colorectal cancer, HALP score, progression-free survival, overall survival, sarcopenia
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1178-7031
Relation: https://www.dovepress.com/hemoglobin-albumin-lymphocyte-platelet-score-as-an-integrative-biomark-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031
Access URL: https://doaj.org/article/cfe6680e04324bc7ad9e2e48e1a36546
Accession Number: edsdoj.fe6680e04324bc7ad9e2e48e1a36546
Database: Directory of Open Access Journals
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://doaj.org/article/cfe6680e04324bc7ad9e2e48e1a36546
    Name: EDS - DOAJ (ns324271)
    Category: fullText
    Text: View record in DOAJ
  – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:edsdoj&genre=article&issn=11787031&ISBN=&volume=18&issue=Issue%201&date=20251001&spage=14709&pages=14709-14720&title=Journal of Inflammation Research&atitle=Hemoglobin-Albumin-Lymphocyte-Platelet%20Score%20as%20an%20Integrative%20Biomarker%20for%20Prognosis%20and%20Sarcopenia%20in%20Colorectal%20Cancer&aulast=Xie%20H&id=DOI:
    Name: Full Text Finder (for New FTF UI) (ns324271)
    Category: fullText
    Text: Full Text Finder
    MouseOverText: Full Text Finder
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.fe6680e04324bc7ad9e2e48e1a36546
RelevancyScore: 1082
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1081.66943359375
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Hemoglobin-Albumin-Lymphocyte-Platelet Score as an Integrative Biomarker for Prognosis and Sarcopenia in Colorectal Cancer
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xie+H%22&quot;&gt;Xie H&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wei+L%22&quot;&gt;Wei L&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tang+S%22&quot;&gt;Tang S&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gan+J%22&quot;&gt;Gan J&lt;/searchLink&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Journal of Inflammation Research, Vol 18, Iss Issue 1, Pp 14709-14720 (2025)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Dove Medical Press, 2025.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2025
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Pathology&lt;br /&gt;LCC:Therapeutics. Pharmacology
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Colorectal+cancer%22&quot;&gt;Colorectal cancer&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22HALP+score%22&quot;&gt;HALP score&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Progression-free+survival%22&quot;&gt;Progression-free survival&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Overall+survival%22&quot;&gt;Overall survival&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Sarcopenia%22&quot;&gt;Sarcopenia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Pathology%22&quot;&gt;Pathology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22RB1-214%22&quot;&gt;RB1-214&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Therapeutics%2E+Pharmacology%22&quot;&gt;Therapeutics. Pharmacology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22RM1-950%22&quot;&gt;RM1-950&lt;/searchLink&gt;
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Hailun Xie,1,2,&amp;ast; Lishuang Wei,3,&amp;ast; Shuangyi Tang,4 Jialiang Gan2,5 1Department of Gastrointestinal and Gland Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 2Guangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, Nanning, Guangxi, People’s Republic of China; 3Department of Geriatric Respiratory Disease Ward, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 4Department of Pharmacy, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 5Department of Colorectal and Anal Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Shuangyi Tang, Department of Pharmacy, the First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, 530021, People’s Republic of China, Email tshy369@sina.com Jialiang Gan, Department of Colorectal and Anal Surgery, the First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, 530021, People’s Republic of China, Tel +86-13878155172, Email gjl5172@163.comObjective: This study aimed to comprehensively investigate the dose-response relationship between the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) score, which reflects the combined inflammatory and nutritional status, and progression-free survival (PFS), overall survival (OS), as well as sarcopenia in patients with colorectal cancer (CRC).Methods: A retrospective analysis was conducted on 1,441 CRC patients who underwent surgery. HALP score was calculated as Hemoglobin (g/L) &#215; Albumin (g/L) &#215; Lymphocyte count (109/L) / Platelet count (109/L). Survival analysis was carried out using Kaplan - Meier curves and Cox regression analysis. Logistic regression analysis was employed to analyze the relationship between the HALP and sarcopenia. HALP - based nomograms were developed to predict 1 - and 5 - year PFS and OS.Results: Kaplan - Meier analysis showed that patients with low HALP scores had worse PFS (51.2% vs 63.3%, p &lt; 0.001) and OS (54.1% vs 66.0%, p &lt; 0.001). For every standard deviation increase in HALP scores, the HR for PFS decreased by 13.3% (HR = 0.867, 95% CI = 0.780– 0.963, p = 0.008), and for OS by 15.2% (HR = 0.848, 95% CI = 0.759– 0.948, p = 0.004). Multivariate Cox regression analysis confirmed HALP as an independent prognostic factor for PFS and OS. Logistic regression analysis indicated that low HALP scores were an independent predictor of sarcopenia (OR = 0.550, 95% CI = 0.420– 0.963, p &lt; 0.001). The HALP-based nomograms demonstrated strong predictive performance for prognosis, with C-indexes of 0.726 (PFS) and 0.728 (OS) and 5-year AUCs exceeding 0.76.Conclusion: Low HALP scores are independent risk factors for PFS, OS, and sarcopenia in CRC patients, highlighting HALP’s potential for clinical application in CRC management and may thus assist in personalized treatment decisions.Keywords: colorectal cancer, HALP score, progression-free survival, overall survival, sarcopenia
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 1178-7031
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://www.dovepress.com/hemoglobin-albumin-lymphocyte-platelet-score-as-an-integrative-biomark-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031
– Name: URL
  Label: Access URL
  Group: URL
  Data: &lt;link linkTarget=&quot;URL&quot; linkTerm=&quot;https://doaj.org/article/cfe6680e04324bc7ad9e2e48e1a36546&quot; linkWindow=&quot;_blank&quot;&gt;https://doaj.org/article/cfe6680e04324bc7ad9e2e48e1a36546&lt;/link&gt;
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.fe6680e04324bc7ad9e2e48e1a36546
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsdoj&AN=edsdoj.fe6680e04324bc7ad9e2e48e1a36546
RecordInfo BibRecord:
  BibEntity:
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 14709
    Subjects:
      – SubjectFull: Colorectal cancer
        Type: general
      – SubjectFull: HALP score
        Type: general
      – SubjectFull: Progression-free survival
        Type: general
      – SubjectFull: Overall survival
        Type: general
      – SubjectFull: Sarcopenia
        Type: general
      – SubjectFull: Pathology
        Type: general
      – SubjectFull: RB1-214
        Type: general
      – SubjectFull: Therapeutics. Pharmacology
        Type: general
      – SubjectFull: RM1-950
        Type: general
    Titles:
      – TitleFull: Hemoglobin-Albumin-Lymphocyte-Platelet Score as an Integrative Biomarker for Prognosis and Sarcopenia in Colorectal Cancer
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Xie H
      – PersonEntity:
          Name:
            NameFull: Wei L
      – PersonEntity:
          Name:
            NameFull: Tang S
      – PersonEntity:
          Name:
            NameFull: Gan J
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 11787031
          Numbering:
            – Type: volume
              Value: 18
            – Type: issue
              Value: Issue 1
          Titles:
            – TitleFull: Journal of Inflammation Research
              Type: main
ResultId 1