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Peptide YY and Glucagon-like Peptide-1 Secretion in Obesity

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Title: Peptide YY and Glucagon-like Peptide-1 Secretion in Obesity
Authors: Jennifer Wilbrink, Mark van Avesaat, Arnold Stronkhorst, Freddy Troost, Carel W le Roux, Ad Masclee
Source: Gastrointestinal Disorders, Vol 7, Iss 1, p 3 (2024)
Publisher Information: MDPI AG, 2024.
Publication Year: 2024
Collection: LCC:Medicine
LCC:Diseases of the digestive system. Gastroenterology
Subject Terms: PYY, GLP-1, secretion, morbid obesity, Medicine, Diseases of the digestive system. Gastroenterology, RC799-869
Description: Objective: The regulation of food intake is disturbed in obesity, possibly resulting from alterations in gut peptide secretion. We hypothesize that obesity is associated with attenuated systemic and tissue concentrations of the gut peptides PYY and GLP-1. Methods: A prospective single-center study in which we included 13 individuals with obesity (BMI 39.5 ± 2.8 kg/m2) and 11 lean individuals as controls (BMI 20.7 ± 1.2 kg/m2) matched for age and gender. We measured: (1) tissue concentrations and mRNA expression of GLP-1 and PYY in ileal and colonic biopsies taken during routine colonoscopy and (2) plasma concentrations of PYY and GLP-1 in response to a meal in the same group. Results: Plasma GLP-1 and PYY responses did not differ between individuals with obesity and lean controls. Neither were tissue concentrations and mRNA expression of both peptides different between both groups. Conclusions: Systemic and local PYY and GLP-1 concentrations in individuals with obesity do not differ from those in lean subjects.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2624-5647
Relation: https://www.mdpi.com/2624-5647/7/1/3; https://doaj.org/toc/2624-5647
DOI: 10.3390/gidisord7010003
Access URL: https://doaj.org/article/eedc7f067dcd419db59fc5b2b4d9633f
Accession Number: edsdoj.7f067dcd419db59fc5b2b4d9633f
Database: Directory of Open Access Journals
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  Data: Peptide YY and Glucagon-like Peptide-1 Secretion in Obesity
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  Data: <searchLink fieldCode="AR" term="%22Jennifer+Wilbrink%22">Jennifer Wilbrink</searchLink><br /><searchLink fieldCode="AR" term="%22Mark+van+Avesaat%22">Mark van Avesaat</searchLink><br /><searchLink fieldCode="AR" term="%22Arnold+Stronkhorst%22">Arnold Stronkhorst</searchLink><br /><searchLink fieldCode="AR" term="%22Freddy+Troost%22">Freddy Troost</searchLink><br /><searchLink fieldCode="AR" term="%22Carel+W+le+Roux%22">Carel W le Roux</searchLink><br /><searchLink fieldCode="AR" term="%22Ad+Masclee%22">Ad Masclee</searchLink>
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  Data: Gastrointestinal Disorders, Vol 7, Iss 1, p 3 (2024)
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  Data: MDPI AG, 2024.
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  Data: 2024
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  Data: LCC:Medicine<br />LCC:Diseases of the digestive system. Gastroenterology
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  Data: <searchLink fieldCode="DE" term="%22PYY%22">PYY</searchLink><br /><searchLink fieldCode="DE" term="%22GLP-1%22">GLP-1</searchLink><br /><searchLink fieldCode="DE" term="%22secretion%22">secretion</searchLink><br /><searchLink fieldCode="DE" term="%22morbid+obesity%22">morbid obesity</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases+of+the+digestive+system%2E+Gastroenterology%22">Diseases of the digestive system. Gastroenterology</searchLink><br /><searchLink fieldCode="DE" term="%22RC799-869%22">RC799-869</searchLink>
– Name: Abstract
  Label: Description
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  Data: Objective: The regulation of food intake is disturbed in obesity, possibly resulting from alterations in gut peptide secretion. We hypothesize that obesity is associated with attenuated systemic and tissue concentrations of the gut peptides PYY and GLP-1. Methods: A prospective single-center study in which we included 13 individuals with obesity (BMI 39.5 ± 2.8 kg/m2) and 11 lean individuals as controls (BMI 20.7 ± 1.2 kg/m2) matched for age and gender. We measured: (1) tissue concentrations and mRNA expression of GLP-1 and PYY in ileal and colonic biopsies taken during routine colonoscopy and (2) plasma concentrations of PYY and GLP-1 in response to a meal in the same group. Results: Plasma GLP-1 and PYY responses did not differ between individuals with obesity and lean controls. Neither were tissue concentrations and mRNA expression of both peptides different between both groups. Conclusions: Systemic and local PYY and GLP-1 concentrations in individuals with obesity do not differ from those in lean subjects.
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  Data: https://www.mdpi.com/2624-5647/7/1/3; https://doaj.org/toc/2624-5647
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        Type: general
      – SubjectFull: GLP-1
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      – SubjectFull: secretion
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              Y: 2024
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