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Intubation of obese patients in the operating room with or without bag-mask ventilation: study protocol for a randomized multicenter trial (VENT OR NOT)

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Title: Intubation of obese patients in the operating room with or without bag-mask ventilation: study protocol for a randomized multicenter trial (VENT OR NOT)
Authors: Souhaïl Znaïdi, Romain Deransy, Karim Asehnoune, Marguerite Le Penndu, Bertrand Rozec, Guillaume Jumel, Sigismond Lasocki, Anna Cadic-Pelletier, Pierre-Grégoire Guinot, Alexis Duchalais, Cédric Cirenei, Stanislas Abrard, Hélène Beloeil, Camille Fortuit, Jérôme Landrin, Guillaume Porta Bonete, Fanny Defrancq, Morgane Péré, Mickaël Vourc’h
Source: Trials, Vol 26, Iss 1, Pp 1-12 (2025)
Publisher Information: BMC, 2025.
Publication Year: 2025
Collection: LCC:Medicine (General)
Subject Terms: Obesity, General anesthesia, Bag-mask ventilation, Tracheal intubation, Intubation-related complications, Medicine (General), R5-920
Description: Abstract Background Almost two-thirds of the adults in Europe are overweight or obese. Obese patients are at higher risk of complications, especially during intubation. Therefore, the management of general anesthesia is crucial. Regarding intubation, there is no consensus among anesthesiologists between the two strategies: standard sequence intubation (i.e., with bag-mask ventilation between induction and intubation) vs. rapid sequence intubation (i.e., without bag-mask ventilation between induction and intubation) assuming that these patients are at high risk of inhalation and desaturation during apnea. This study aims to compare the incidence of intubation-related complications between these two strategies in severely obese patients undergoing elective surgery. Methods The VENT OR NOT study is a prospective, multicenter, open-label, randomized trial including obese patients with a body mass index ≥ 35 kg/m2 requiring tracheal intubation before scheduled surgery. We will assess the superiority of the standard sequence intubation (“VENT strategy”) compared with the rapid sequence intubation (“NO VENT strategy”) to prevent intubation-related complications in 702 obese patients. Enrolment started in September 2023 in 13 French academic and nonacademic hospitals and is expected to finish in September 2025. The primary outcome is a composite criterion of complications occurring from the induction of general anesthesia up to 10 min after intubation including: oxygen desaturation
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1745-6215
Relation: https://doaj.org/toc/1745-6215
DOI: 10.1186/s13063-025-09114-z
Access URL: https://doaj.org/article/2250ffdb8bd749d18b90c93d74e7a05e
Accession Number: edsdoj.2250ffdb8bd749d18b90c93d74e7a05e
Database: Directory of Open Access Journals
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  Data: Abstract Background Almost two-thirds of the adults in Europe are overweight or obese. Obese patients are at higher risk of complications, especially during intubation. Therefore, the management of general anesthesia is crucial. Regarding intubation, there is no consensus among anesthesiologists between the two strategies: standard sequence intubation (i.e., with bag-mask ventilation between induction and intubation) vs. rapid sequence intubation (i.e., without bag-mask ventilation between induction and intubation) assuming that these patients are at high risk of inhalation and desaturation during apnea. This study aims to compare the incidence of intubation-related complications between these two strategies in severely obese patients undergoing elective surgery. Methods The VENT OR NOT study is a prospective, multicenter, open-label, randomized trial including obese patients with a body mass index ≥ 35 kg/m2 requiring tracheal intubation before scheduled surgery. We will assess the superiority of the standard sequence intubation (“VENT strategy”) compared with the rapid sequence intubation (“NO VENT strategy”) to prevent intubation-related complications in 702 obese patients. Enrolment started in September 2023 in 13 French academic and nonacademic hospitals and is expected to finish in September 2025. The primary outcome is a composite criterion of complications occurring from the induction of general anesthesia up to 10 min after intubation including: oxygen desaturation
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