Academic Journal
Impaired Direction Selectivity in the Nucleus of the Optic Tract of Albino Mice
| Τίτλος: | Impaired Direction Selectivity in the Nucleus of the Optic Tract of Albino Mice |
|---|---|
| Συγγραφείς: | Montijn, Jorrit S, Riguccini, Valentina, Levelt, Christiaan N, Heimel, J Alexander |
| Πηγή: | Montijn, J S, Riguccini, V, Levelt, C N & Heimel, J A 2023, 'Impaired Direction Selectivity in the Nucleus of the Optic Tract of Albino Mice', Investigative Ophthalmology & Visual Science, vol. 64, no. 11, 9. https://doi.org/10.1167/iovs.64.11.9 |
| Έτος έκδοσης: | 2023 |
| Συλλογή: | KNAW: Research Explorer (Koninklijke Nederlandse Akademie van Wetenschappen / Royal Netherlands Academy of Arts and Sciences) |
| Θεματικοί όροι: | Humans, Mice, Animals, Visual Pathways/physiology, Pretectal Region, Inbred C57BL, Inbred DBA, Nystagmus, Optokinetic, Pathologic, Retinal Ganglion Cells, Albinism |
| Περιγραφή: | PURPOSE: Human albinos have a low visual acuity. This is partially due to the presence of spontaneous erroneous eye movements called pendular nystagmus. This nystagmus is present in other albino vertebrates and has been hypothesized to be caused by aberrant wiring of retinal ganglion axons to the nucleus of the optic tract (NOT), a part of the accessory optic system involved in the optokinetic response to visual motion. The NOT in pigmented rodents is preferentially responsive to ipsiversive motion (i.e., motion in the contralateral visual field in the temporonasal direction). We compared the response to visual motion in the NOT of albino and pigmented mice to understand if motion coding and preference are impaired in the NOT of albino mice. METHODS: We recorded neuronal spiking activity with Neuropixels probes in the visual cortex and NOT in C57BL/6JRj mice (pigmented) and DBA/1JRj mice with oculocutaneous albinism (albino). RESULTS: We found that in pigmented mice, NOT is retinotopically organized, and neurons are direction tuned, whereas in albino mice, neuronal tuning is severely impaired. Neurons in the NOT of albino mice do not have a preference for ipsiversive movement. In contrast, neuronal tuning in visual cortex was preserved in albino mice and did not differ significantly from the tuning in pigmented mice. CONCLUSIONS: We propose that excessive interhemispheric crossing of retinal projections in albinos may cause the disrupted left/right direction encoding we found in NOT. This, in turn, impairs the normal horizontal optokinetic reflex and leads to pendular albino nystagmus. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 0146-0404 1552-5783 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37548962; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/20.500.11755/f8883586-ed84-4096-b890-dc5e2ca69dff; info:eu-repo/semantics/altIdentifier/pissn/0146-0404; info:eu-repo/semantics/altIdentifier/eissn/1552-5783 |
| DOI: | 10.1167/iovs.64.11.9 |
| Διαθεσιμότητα: | https://pure.knaw.nl/portal/en/publications/f8883586-ed84-4096-b890-dc5e2ca69dff https://doi.org/10.1167/iovs.64.11.9 https://hdl.handle.net/20.500.11755/f8883586-ed84-4096-b890-dc5e2ca69dff https://pure.knaw.nl/ws/files/1045836257/Levelt2023.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| Αριθμός Καταχώρησης: | edsbas.FAB228A2 |
| Βάση Δεδομένων: | BASE |
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| Items | – Name: Title Label: Title Group: Ti Data: Impaired Direction Selectivity in the Nucleus of the Optic Tract of Albino Mice – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Montijn%2C+Jorrit+S%22">Montijn, Jorrit S</searchLink><br /><searchLink fieldCode="AR" term="%22Riguccini%2C+Valentina%22">Riguccini, Valentina</searchLink><br /><searchLink fieldCode="AR" term="%22Levelt%2C+Christiaan+N%22">Levelt, Christiaan N</searchLink><br /><searchLink fieldCode="AR" term="%22Heimel%2C+J+Alexander%22">Heimel, J Alexander</searchLink> – Name: TitleSource Label: Source Group: Src Data: Montijn, J S, Riguccini, V, Levelt, C N & Heimel, J A 2023, 'Impaired Direction Selectivity in the Nucleus of the Optic Tract of Albino Mice', Investigative Ophthalmology & Visual Science, vol. 64, no. 11, 9. https://doi.org/10.1167/iovs.64.11.9 – Name: DatePubCY Label: Publication Year Group: Date Data: 2023 – Name: Subset Label: Collection Group: HoldingsInfo Data: KNAW: Research Explorer (Koninklijke Nederlandse Akademie van Wetenschappen / Royal Netherlands Academy of Arts and Sciences) – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink><br /><searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Visual+Pathways%2Fphysiology%22">Visual Pathways/physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Pretectal+Region%22">Pretectal Region</searchLink><br /><searchLink fieldCode="DE" term="%22Inbred+C57BL%22">Inbred C57BL</searchLink><br /><searchLink fieldCode="DE" term="%22Inbred+DBA%22">Inbred DBA</searchLink><br /><searchLink fieldCode="DE" term="%22Nystagmus%22">Nystagmus</searchLink><br /><searchLink fieldCode="DE" term="%22Optokinetic%22">Optokinetic</searchLink><br /><searchLink fieldCode="DE" term="%22Pathologic%22">Pathologic</searchLink><br /><searchLink fieldCode="DE" term="%22Retinal+Ganglion+Cells%22">Retinal Ganglion Cells</searchLink><br /><searchLink fieldCode="DE" term="%22Albinism%22">Albinism</searchLink> – Name: Abstract Label: Description Group: Ab Data: PURPOSE: Human albinos have a low visual acuity. This is partially due to the presence of spontaneous erroneous eye movements called pendular nystagmus. This nystagmus is present in other albino vertebrates and has been hypothesized to be caused by aberrant wiring of retinal ganglion axons to the nucleus of the optic tract (NOT), a part of the accessory optic system involved in the optokinetic response to visual motion. The NOT in pigmented rodents is preferentially responsive to ipsiversive motion (i.e., motion in the contralateral visual field in the temporonasal direction). We compared the response to visual motion in the NOT of albino and pigmented mice to understand if motion coding and preference are impaired in the NOT of albino mice. METHODS: We recorded neuronal spiking activity with Neuropixels probes in the visual cortex and NOT in C57BL/6JRj mice (pigmented) and DBA/1JRj mice with oculocutaneous albinism (albino). RESULTS: We found that in pigmented mice, NOT is retinotopically organized, and neurons are direction tuned, whereas in albino mice, neuronal tuning is severely impaired. Neurons in the NOT of albino mice do not have a preference for ipsiversive movement. In contrast, neuronal tuning in visual cortex was preserved in albino mice and did not differ significantly from the tuning in pigmented mice. CONCLUSIONS: We propose that excessive interhemispheric crossing of retinal projections in albinos may cause the disrupted left/right direction encoding we found in NOT. This, in turn, impairs the normal horizontal optokinetic reflex and leads to pendular albino nystagmus. – Name: TypeDocument Label: Document Type Group: TypDoc Data: article in journal/newspaper – Name: Format Label: File Description Group: SrcInfo Data: application/pdf – Name: Language Label: Language Group: Lang Data: English – Name: ISSN Label: ISSN Group: ISSN Data: 0146-0404<br />1552-5783 – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: info:eu-repo/semantics/altIdentifier/pmid/37548962; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/20.500.11755/f8883586-ed84-4096-b890-dc5e2ca69dff; info:eu-repo/semantics/altIdentifier/pissn/0146-0404; info:eu-repo/semantics/altIdentifier/eissn/1552-5783 – Name: DOI Label: DOI Group: ID Data: 10.1167/iovs.64.11.9 – Name: URL Label: Availability Group: URL Data: https://pure.knaw.nl/portal/en/publications/f8883586-ed84-4096-b890-dc5e2ca69dff<br />https://doi.org/10.1167/iovs.64.11.9<br />https://hdl.handle.net/20.500.11755/f8883586-ed84-4096-b890-dc5e2ca69dff<br />https://pure.knaw.nl/ws/files/1045836257/Levelt2023.pdf – Name: Copyright Label: Rights Group: Cpyrght Data: info:eu-repo/semantics/openAccess – Name: AN Label: Accession Number Group: ID Data: edsbas.FAB228A2 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1167/iovs.64.11.9 Languages: – Text: English Subjects: – SubjectFull: Humans Type: general – SubjectFull: Mice Type: general – SubjectFull: Animals Type: general – SubjectFull: Visual Pathways/physiology Type: general – SubjectFull: Pretectal Region Type: general – SubjectFull: Inbred C57BL Type: general – SubjectFull: Inbred DBA Type: general – SubjectFull: Nystagmus Type: general – SubjectFull: Optokinetic Type: general – SubjectFull: Pathologic Type: general – SubjectFull: Retinal Ganglion Cells Type: general – SubjectFull: Albinism Type: general Titles: – TitleFull: Impaired Direction Selectivity in the Nucleus of the Optic Tract of Albino Mice Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Montijn, Jorrit S – PersonEntity: Name: NameFull: Riguccini, Valentina – PersonEntity: Name: NameFull: Levelt, Christiaan N – PersonEntity: Name: NameFull: Heimel, J Alexander IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 01460404 – Type: issn-print Value: 15525783 – Type: issn-locals Value: edsbas – Type: issn-locals Value: edsbas.oa Titles: – TitleFull: Montijn, J S, Riguccini, V, Levelt, C N & Heimel, J A 2023, 'Impaired Direction Selectivity in the Nucleus of the Optic Tract of Albino Mice', Investigative Ophthalmology & Visual Science, vol. 64, no. 11, 9. https://doi.org/10.1167/iovs.64.11.9 Type: main |
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