Academic Journal
Associations of C-reactive protein with depressive symptoms over time after mild to moderate ischemic stroke in the PROSCIS-B cohort
| Τίτλος: | Associations of C-reactive protein with depressive symptoms over time after mild to moderate ischemic stroke in the PROSCIS-B cohort |
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| Συγγραφείς: | Schaeff, Viktoria L. K., Sperber, Pia S., Piper, Sophie K., Giesers, Naomi K., Gertz, Karen, Heuschmann, Peter U., Endres, Matthias, Liman, Thomas G. |
| Έτος έκδοσης: | 2023 |
| Συλλογή: | FU Berlin: Refubium |
| Θεματικοί όροι: | inflammation, hs-crp, ischemic stroke, depression, ddc:610 |
| Περιγραφή: | Background and purpose: C-reactive protein serves as a marker of inflammation and is linked to depression in the general population. We aimed to assess whether elevated baseline levels of high-sensitivity C-reactive protein (hs-CRP) are associated with depressive symptoms over time in a prospective cohort of mild-to-moderate first-ever ischemic stroke patients.Methods: Data were obtained from the Prospective Cohort with Incident Stroke Berlin (NCT01363856). Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D) at three annual follow-up points. We assessed the association of elevated levels of hs-CRP with CES-D scores over time via linear mixed models. In a subgroup analysis, we explored an interaction effect with sex.Results: We included 585 ischemic stroke patients with baseline data on CRP levels. The mean age was 67 (13 SD), 39% (n = 226) were female, and the median National Institutes of Health Stroke Scale (NIHSS) was 3 (IQR 1-4). Twenty percent of survivors showed evidence for depressive symptoms one year after stroke with CES-D >= 16, 21% at year two, and 17% at year three. Higher log-transformed baseline hs-CRP levels were associated with higher CES-D Scores over time in the adjusted linear mixed model (beta = 1.28; (95% CI 0.22-2.34)). The subgroup analysis revealed an interaction effect of hs-CRP on depressive symptoms in women (beta = 2.33; (95% CI 0.71-3.95)).Conclusion: In our cohort with mild-to-moderate first-ever ischemic stroke patients, hs-CRP levels were associated with more depressive symptoms over time, with an interaction effect for the female sex.Study registration: https://clinicaltrials.gov; Unique identifier: NCT01363856. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| DOI: | 10.17169/refubium-49529 |
| DOI: | 10.1007/s00415-023-12038-w |
| Διαθεσιμότητα: | https://refubium.fu-berlin.de/handle/fub188/49804 https://doi.org/10.17169/refubium-49529 https://doi.org/10.1007/s00415-023-12038-w |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Αριθμός Καταχώρησης: | edsbas.F8D7D50F |
| Βάση Δεδομένων: | BASE |
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