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Associations of C-reactive protein with depressive symptoms over time after mild to moderate ischemic stroke in the PROSCIS-B cohort

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Τίτλος: Associations of C-reactive protein with depressive symptoms over time after mild to moderate ischemic stroke in the PROSCIS-B cohort
Συγγραφείς: Schaeff, Viktoria L. K., Sperber, Pia S., Piper, Sophie K., Giesers, Naomi K., Gertz, Karen, Heuschmann, Peter U., Endres, Matthias, Liman, Thomas G.
Έτος έκδοσης: 2023
Συλλογή: FU Berlin: Refubium
Θεματικοί όροι: inflammation, hs-crp, ischemic stroke, depression, ddc:610
Περιγραφή: Background and purpose: C-reactive protein serves as a marker of inflammation and is linked to depression in the general population. We aimed to assess whether elevated baseline levels of high-sensitivity C-reactive protein (hs-CRP) are associated with depressive symptoms over time in a prospective cohort of mild-to-moderate first-ever ischemic stroke patients.Methods: Data were obtained from the Prospective Cohort with Incident Stroke Berlin (NCT01363856). Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D) at three annual follow-up points. We assessed the association of elevated levels of hs-CRP with CES-D scores over time via linear mixed models. In a subgroup analysis, we explored an interaction effect with sex.Results: We included 585 ischemic stroke patients with baseline data on CRP levels. The mean age was 67 (13 SD), 39% (n = 226) were female, and the median National Institutes of Health Stroke Scale (NIHSS) was 3 (IQR 1-4). Twenty percent of survivors showed evidence for depressive symptoms one year after stroke with CES-D >= 16, 21% at year two, and 17% at year three. Higher log-transformed baseline hs-CRP levels were associated with higher CES-D Scores over time in the adjusted linear mixed model (beta = 1.28; (95% CI 0.22-2.34)). The subgroup analysis revealed an interaction effect of hs-CRP on depressive symptoms in women (beta = 2.33; (95% CI 0.71-3.95)).Conclusion: In our cohort with mild-to-moderate first-ever ischemic stroke patients, hs-CRP levels were associated with more depressive symptoms over time, with an interaction effect for the female sex.Study registration: https://clinicaltrials.gov; Unique identifier: NCT01363856.
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: application/pdf
Γλώσσα: English
DOI: 10.17169/refubium-49529
DOI: 10.1007/s00415-023-12038-w
Διαθεσιμότητα: https://refubium.fu-berlin.de/handle/fub188/49804
https://doi.org/10.17169/refubium-49529
https://doi.org/10.1007/s00415-023-12038-w
Rights: https://creativecommons.org/licenses/by/4.0/
Αριθμός Καταχώρησης: edsbas.F8D7D50F
Βάση Δεδομένων: BASE
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  – Url: https://refubium.fu-berlin.de/handle/fub188/49804#
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  Data: Associations of C-reactive protein with depressive symptoms over time after mild to moderate ischemic stroke in the PROSCIS-B cohort
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  Data: <searchLink fieldCode="AR" term="%22Schaeff%2C+Viktoria+L%2E+K%2E%22">Schaeff, Viktoria L. K.</searchLink><br /><searchLink fieldCode="AR" term="%22Sperber%2C+Pia+S%2E%22">Sperber, Pia S.</searchLink><br /><searchLink fieldCode="AR" term="%22Piper%2C+Sophie+K%2E%22">Piper, Sophie K.</searchLink><br /><searchLink fieldCode="AR" term="%22Giesers%2C+Naomi+K%2E%22">Giesers, Naomi K.</searchLink><br /><searchLink fieldCode="AR" term="%22Gertz%2C+Karen%22">Gertz, Karen</searchLink><br /><searchLink fieldCode="AR" term="%22Heuschmann%2C+Peter+U%2E%22">Heuschmann, Peter U.</searchLink><br /><searchLink fieldCode="AR" term="%22Endres%2C+Matthias%22">Endres, Matthias</searchLink><br /><searchLink fieldCode="AR" term="%22Liman%2C+Thomas+G%2E%22">Liman, Thomas G.</searchLink>
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  Data: 2023
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  Data: FU Berlin: Refubium
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  Data: <searchLink fieldCode="DE" term="%22inflammation%22">inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22hs-crp%22">hs-crp</searchLink><br /><searchLink fieldCode="DE" term="%22ischemic+stroke%22">ischemic stroke</searchLink><br /><searchLink fieldCode="DE" term="%22depression%22">depression</searchLink><br /><searchLink fieldCode="DE" term="%22ddc%3A610%22">ddc:610</searchLink>
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  Label: Description
  Group: Ab
  Data: Background and purpose: C-reactive protein serves as a marker of inflammation and is linked to depression in the general population. We aimed to assess whether elevated baseline levels of high-sensitivity C-reactive protein (hs-CRP) are associated with depressive symptoms over time in a prospective cohort of mild-to-moderate first-ever ischemic stroke patients.Methods: Data were obtained from the Prospective Cohort with Incident Stroke Berlin (NCT01363856). Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D) at three annual follow-up points. We assessed the association of elevated levels of hs-CRP with CES-D scores over time via linear mixed models. In a subgroup analysis, we explored an interaction effect with sex.Results: We included 585 ischemic stroke patients with baseline data on CRP levels. The mean age was 67 (13 SD), 39% (n = 226) were female, and the median National Institutes of Health Stroke Scale (NIHSS) was 3 (IQR 1-4). Twenty percent of survivors showed evidence for depressive symptoms one year after stroke with CES-D >= 16, 21% at year two, and 17% at year three. Higher log-transformed baseline hs-CRP levels were associated with higher CES-D Scores over time in the adjusted linear mixed model (beta = 1.28; (95% CI 0.22-2.34)). The subgroup analysis revealed an interaction effect of hs-CRP on depressive symptoms in women (beta = 2.33; (95% CI 0.71-3.95)).Conclusion: In our cohort with mild-to-moderate first-ever ischemic stroke patients, hs-CRP levels were associated with more depressive symptoms over time, with an interaction effect for the female sex.Study registration: https://clinicaltrials.gov; Unique identifier: NCT01363856.
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      – SubjectFull: hs-crp
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      – SubjectFull: ischemic stroke
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