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Tricuspid and mitral valve regurgitation in a chronic canine model implanted with a novel leadless pacemaker

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Τίτλος: Tricuspid and mitral valve regurgitation in a chronic canine model implanted with a novel leadless pacemaker
Συγγραφείς: Breeman, KTN, Knops, RE, Swackhamer, B, Kilvington, J, Soltis, B, Shuros, A, Brisben, A, Carter, N, Burke, MC, Tjong, FVY
Πηγή: EP Europace ; volume 23, issue Supplement_3 ; ISSN 1099-5129 1532-2092
Στοιχεία εκδότη: Oxford University Press (OUP)
Έτος έκδοσης: 2021
Περιγραφή: Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Boston Scientific and Abbott Background One of the presumed advantages of leadless pacemaker (LP) therapy is that tricuspid regurgitation (TR) occurrence and severity would be less than with conventional pacemakers due to the absence of leads. However, TR and mitral regurgitation (MR) may also worsen due to chronic right ventricular (RV) pacing per se. Purpose To determine whether a novel LP is associated with increased TR and MR severity in a chronic canine model and to evaluate predictors of TR and MR worsening. Methods Healthy canine subjects were implanted with a novel LP programmed at a lower rate of 80/min. TR and MR were assessed by transthoracic echocardiography (TTE) prior to implant, at 90 days and at 18 months after implant. Further were assessed percentage of pacing, presence of pacing during TTE, and wall motion abnormalities (WMA) observed during TTE, indicating ventriculo-ventricular dyssynchronous pacing. Paired t-tests were performed to compare TR and MR severity before and after implant. Univariable and multivariable generalized estimating equation (GEE) models were used to evaluate factors predictive of increased TR and MR severity. Paired t-tests were used to evaluate whether the increase of TR and MR differed between subgroups where pacing or WMA were observed or not. Results An LP was implanted in 73 subjects. TR and MR severity at 90 days (n = 55) were significantly increased from baseline (p = 0.02 and 0.001, confidence intervals [CIs] 0.05-0.64 and 0.20-0.75, respectively); at 18 months (n = 37) TR severity remained significantly increased but MR did not (p = 0.01 and 0.62, CI [0.09, 0.69] and [-0.15, 0.25], respectively). Multivariable GEE (figure) showed that WMA and absence of TR at baseline are significant predictors for increased TR, while WMA and a shorter RV long axis are significant predictors for increased MR. Subgroup analysis demonstrated that TR and MR at day 90 were only ...
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
DOI: 10.1093/europace/euab116.484
Διαθεσιμότητα: https://doi.org/10.1093/europace/euab116.484
http://academic.oup.com/europace/article-pdf/23/Supplement_3/euab116.484/38131871/euab116.484.pdf
Rights: https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
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  Data: Tricuspid and mitral valve regurgitation in a chronic canine model implanted with a novel leadless pacemaker
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  Data: EP Europace ; volume 23, issue Supplement_3 ; ISSN 1099-5129 1532-2092
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  Data: Oxford University Press (OUP)
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  Data: 2021
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  Data: Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Boston Scientific and Abbott Background One of the presumed advantages of leadless pacemaker (LP) therapy is that tricuspid regurgitation (TR) occurrence and severity would be less than with conventional pacemakers due to the absence of leads. However, TR and mitral regurgitation (MR) may also worsen due to chronic right ventricular (RV) pacing per se. Purpose To determine whether a novel LP is associated with increased TR and MR severity in a chronic canine model and to evaluate predictors of TR and MR worsening. Methods Healthy canine subjects were implanted with a novel LP programmed at a lower rate of 80/min. TR and MR were assessed by transthoracic echocardiography (TTE) prior to implant, at 90 days and at 18 months after implant. Further were assessed percentage of pacing, presence of pacing during TTE, and wall motion abnormalities (WMA) observed during TTE, indicating ventriculo-ventricular dyssynchronous pacing. Paired t-tests were performed to compare TR and MR severity before and after implant. Univariable and multivariable generalized estimating equation (GEE) models were used to evaluate factors predictive of increased TR and MR severity. Paired t-tests were used to evaluate whether the increase of TR and MR differed between subgroups where pacing or WMA were observed or not. Results An LP was implanted in 73 subjects. TR and MR severity at 90 days (n = 55) were significantly increased from baseline (p = 0.02 and 0.001, confidence intervals [CIs] 0.05-0.64 and 0.20-0.75, respectively); at 18 months (n = 37) TR severity remained significantly increased but MR did not (p = 0.01 and 0.62, CI [0.09, 0.69] and [-0.15, 0.25], respectively). Multivariable GEE (figure) showed that WMA and absence of TR at baseline are significant predictors for increased TR, while WMA and a shorter RV long axis are significant predictors for increased MR. Subgroup analysis demonstrated that TR and MR at day 90 were only ...
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  Data: 10.1093/europace/euab116.484
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