Book
Proteomic dissection of Alzheimer’s disease pathology
| Τίτλος: | Proteomic dissection of Alzheimer’s disease pathology |
|---|---|
| Συγγραφείς: | Hondius, David Carolus |
| Πηγή: | Hondius, D C 2022, 'Proteomic dissection of Alzheimer’s disease pathology', Dr., Vrije Universiteit Amsterdam, s.l. |
| Έτος έκδοσης: | 2022 |
| Θεματικοί όροι: | Zs.liekte van Alzheimer, Proteomics, Cerebrale amyloïde angiopathie, Postmortaal menselijk brein, Biomarkers, Laserdissectie, Amyloïde bèta, Tau, Granulovacuolaire degeneratie, Alzheimer's disease, Cerebral amyloid angiopathy, Postmortem human brain, Laserdissection, Amyloid beta, Granulovacuolar degeneration |
| Περιγραφή: | AD pathology is characterized by the presence of amyloid beta (Aβ) aggregates, as plaques in the brain parenchyma and around the brain vasculature as Cerebral Amyloid Angiopathy (CAA). In addition, AD pathology is hallmarked by the presence of intraneuronal aggregates of tau protein as neurofibrillary tangles (NFTs). Another feature in AD is the increased presence of granulovacuolar degeneration (GVD) bodies which are considered to be associated with a pre-tangle stage in neuronal tau pathology. There is a positive correlation between the increase and distribution of these features and the clinical symptoms. However, there is a long pre-symptomatic phase of AD, in which brain pathology builds up and neurodegeneration starts to occur. Hence, earlier diagnosis is probably essential for a better chance of success in treating AD. In addition, AD can be clinically and pathologically divers. Disease heterogeneity, and possible differences in disease mechanisms, could also explain why past clinical trials have not yielded satisfying results, as different patients or patient groups might require different therapies. Increased insight in early disease mechanisms is highly needed and there is a clinical need to identify novel biomarkers for early, pre-symptomatic diagnosis and patient stratification. A useful approach is to identify changes in the proteome in brain tissue from AD patients. We analyzed the proteome of the CA1 and subiculum regions from the hippocampus of 40 cases derived from all stages of AD as defined by the Braak stages for tau pathology (Chapter 2). This allowed differentiation between early and late changes in protein abundance during the development of AD pathology. The abundance of 372 proteins was altered, including several proteins not linked to AD previously. Protein groups that displayed similar expression profiles over the disease course were identified and linked to specific cell-types and functional cellular processes. Next we successfully established a single cell type proteomics workflow, ... |
| Τύπος εγγράφου: | book |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/1871.1/ae7045de-7b97-42dc-876f-405c3d4b1e13 |
| Διαθεσιμότητα: | https://research.vu.nl/en/publications/ae7045de-7b97-42dc-876f-405c3d4b1e13 https://hdl.handle.net/1871.1/ae7045de-7b97-42dc-876f-405c3d4b1e13 https://research.vu.nl/ws/files/149971235/D%20C%20%20Hondius%20-%20thesis.pdf https://research.vu.nl/ws/files/149971237/D%20C%20%20Hondius%20-%20cover.pdf https://research.vu.nl/ws/files/149971239/D%20C%20%20Hondius%20-%20toc.pdf https://research.vu.nl/ws/files/149971241/D%20C%20%20Hondius%20-%20title_page.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| Αριθμός Καταχώρησης: | edsbas.F226E4 |
| Βάση Δεδομένων: | BASE |
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