Book
Proteomic dissection of Alzheimer’s disease pathology
| Τίτλος: | Proteomic dissection of Alzheimer’s disease pathology |
|---|---|
| Συγγραφείς: | Hondius, David Carolus |
| Πηγή: | Hondius, D C 2022, 'Proteomic dissection of Alzheimer’s disease pathology', Dr., Vrije Universiteit Amsterdam, s.l. |
| Έτος έκδοσης: | 2022 |
| Θεματικοί όροι: | Zs.liekte van Alzheimer, Proteomics, Cerebrale amyloïde angiopathie, Postmortaal menselijk brein, Biomarkers, Laserdissectie, Amyloïde bèta, Tau, Granulovacuolaire degeneratie, Alzheimer's disease, Cerebral amyloid angiopathy, Postmortem human brain, Laserdissection, Amyloid beta, Granulovacuolar degeneration |
| Περιγραφή: | AD pathology is characterized by the presence of amyloid beta (Aβ) aggregates, as plaques in the brain parenchyma and around the brain vasculature as Cerebral Amyloid Angiopathy (CAA). In addition, AD pathology is hallmarked by the presence of intraneuronal aggregates of tau protein as neurofibrillary tangles (NFTs). Another feature in AD is the increased presence of granulovacuolar degeneration (GVD) bodies which are considered to be associated with a pre-tangle stage in neuronal tau pathology. There is a positive correlation between the increase and distribution of these features and the clinical symptoms. However, there is a long pre-symptomatic phase of AD, in which brain pathology builds up and neurodegeneration starts to occur. Hence, earlier diagnosis is probably essential for a better chance of success in treating AD. In addition, AD can be clinically and pathologically divers. Disease heterogeneity, and possible differences in disease mechanisms, could also explain why past clinical trials have not yielded satisfying results, as different patients or patient groups might require different therapies. Increased insight in early disease mechanisms is highly needed and there is a clinical need to identify novel biomarkers for early, pre-symptomatic diagnosis and patient stratification. A useful approach is to identify changes in the proteome in brain tissue from AD patients. We analyzed the proteome of the CA1 and subiculum regions from the hippocampus of 40 cases derived from all stages of AD as defined by the Braak stages for tau pathology (Chapter 2). This allowed differentiation between early and late changes in protein abundance during the development of AD pathology. The abundance of 372 proteins was altered, including several proteins not linked to AD previously. Protein groups that displayed similar expression profiles over the disease course were identified and linked to specific cell-types and functional cellular processes. Next we successfully established a single cell type proteomics workflow, ... |
| Τύπος εγγράφου: | book |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/1871.1/ae7045de-7b97-42dc-876f-405c3d4b1e13 |
| Διαθεσιμότητα: | https://research.vu.nl/en/publications/ae7045de-7b97-42dc-876f-405c3d4b1e13 https://hdl.handle.net/1871.1/ae7045de-7b97-42dc-876f-405c3d4b1e13 https://research.vu.nl/ws/files/149971235/D%20C%20%20Hondius%20-%20thesis.pdf https://research.vu.nl/ws/files/149971237/D%20C%20%20Hondius%20-%20cover.pdf https://research.vu.nl/ws/files/149971239/D%20C%20%20Hondius%20-%20toc.pdf https://research.vu.nl/ws/files/149971241/D%20C%20%20Hondius%20-%20title_page.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| Αριθμός Καταχώρησης: | edsbas.F226E4 |
| Βάση Δεδομένων: | BASE |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://research.vu.nl/en/publications/ae7045de-7b97-42dc-876f-405c3d4b1e13# Name: EDS - BASE (ns324271) Category: fullText Text: View record from BASE |
|---|---|
| Header | DbId: edsbas DbLabel: BASE An: edsbas.F226E4 RelevancyScore: 935 AccessLevel: 3 PubType: Book PubTypeId: book PreciseRelevancyScore: 935.2763671875 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Proteomic dissection of Alzheimer’s disease pathology – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hondius%2C+David+Carolus%22">Hondius, David Carolus</searchLink> – Name: TitleSource Label: Source Group: Src Data: Hondius, D C 2022, 'Proteomic dissection of Alzheimer’s disease pathology', Dr., Vrije Universiteit Amsterdam, s.l. – Name: DatePubCY Label: Publication Year Group: Date Data: 2022 – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Zs%2Eliekte+van+Alzheimer%22">Zs.liekte van Alzheimer</searchLink><br /><searchLink fieldCode="DE" term="%22Proteomics%22">Proteomics</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebrale+amyloïde+angiopathie%22">Cerebrale amyloïde angiopathie</searchLink><br /><searchLink fieldCode="DE" term="%22Postmortaal+menselijk+brein%22">Postmortaal menselijk brein</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Laserdissectie%22">Laserdissectie</searchLink><br /><searchLink fieldCode="DE" term="%22Amyloïde+bèta%22">Amyloïde bèta</searchLink><br /><searchLink fieldCode="DE" term="%22Tau%22">Tau</searchLink><br /><searchLink fieldCode="DE" term="%22Granulovacuolaire+degeneratie%22">Granulovacuolaire degeneratie</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+amyloid+angiopathy%22">Cerebral amyloid angiopathy</searchLink><br /><searchLink fieldCode="DE" term="%22Postmortem+human+brain%22">Postmortem human brain</searchLink><br /><searchLink fieldCode="DE" term="%22Laserdissection%22">Laserdissection</searchLink><br /><searchLink fieldCode="DE" term="%22Amyloid+beta%22">Amyloid beta</searchLink><br /><searchLink fieldCode="DE" term="%22Granulovacuolar+degeneration%22">Granulovacuolar degeneration</searchLink> – Name: Abstract Label: Description Group: Ab Data: AD pathology is characterized by the presence of amyloid beta (Aβ) aggregates, as plaques in the brain parenchyma and around the brain vasculature as Cerebral Amyloid Angiopathy (CAA). In addition, AD pathology is hallmarked by the presence of intraneuronal aggregates of tau protein as neurofibrillary tangles (NFTs). Another feature in AD is the increased presence of granulovacuolar degeneration (GVD) bodies which are considered to be associated with a pre-tangle stage in neuronal tau pathology. There is a positive correlation between the increase and distribution of these features and the clinical symptoms. However, there is a long pre-symptomatic phase of AD, in which brain pathology builds up and neurodegeneration starts to occur. Hence, earlier diagnosis is probably essential for a better chance of success in treating AD. In addition, AD can be clinically and pathologically divers. Disease heterogeneity, and possible differences in disease mechanisms, could also explain why past clinical trials have not yielded satisfying results, as different patients or patient groups might require different therapies. Increased insight in early disease mechanisms is highly needed and there is a clinical need to identify novel biomarkers for early, pre-symptomatic diagnosis and patient stratification. A useful approach is to identify changes in the proteome in brain tissue from AD patients. We analyzed the proteome of the CA1 and subiculum regions from the hippocampus of 40 cases derived from all stages of AD as defined by the Braak stages for tau pathology (Chapter 2). This allowed differentiation between early and late changes in protein abundance during the development of AD pathology. The abundance of 372 proteins was altered, including several proteins not linked to AD previously. Protein groups that displayed similar expression profiles over the disease course were identified and linked to specific cell-types and functional cellular processes. Next we successfully established a single cell type proteomics workflow, ... – Name: TypeDocument Label: Document Type Group: TypDoc Data: book – Name: Format Label: File Description Group: SrcInfo Data: application/pdf – Name: Language Label: Language Group: Lang Data: English – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/1871.1/ae7045de-7b97-42dc-876f-405c3d4b1e13 – Name: URL Label: Availability Group: URL Data: https://research.vu.nl/en/publications/ae7045de-7b97-42dc-876f-405c3d4b1e13<br />https://hdl.handle.net/1871.1/ae7045de-7b97-42dc-876f-405c3d4b1e13<br />https://research.vu.nl/ws/files/149971235/D%20C%20%20Hondius%20-%20thesis.pdf<br />https://research.vu.nl/ws/files/149971237/D%20C%20%20Hondius%20-%20cover.pdf<br />https://research.vu.nl/ws/files/149971239/D%20C%20%20Hondius%20-%20toc.pdf<br />https://research.vu.nl/ws/files/149971241/D%20C%20%20Hondius%20-%20title_page.pdf – Name: Copyright Label: Rights Group: Cpyrght Data: info:eu-repo/semantics/openAccess – Name: AN Label: Accession Number Group: ID Data: edsbas.F226E4 |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.F226E4 |
| RecordInfo | BibRecord: BibEntity: Languages: – Text: English Subjects: – SubjectFull: Zs.liekte van Alzheimer Type: general – SubjectFull: Proteomics Type: general – SubjectFull: Cerebrale amyloïde angiopathie Type: general – SubjectFull: Postmortaal menselijk brein Type: general – SubjectFull: Biomarkers Type: general – SubjectFull: Laserdissectie Type: general – SubjectFull: Amyloïde bèta Type: general – SubjectFull: Tau Type: general – SubjectFull: Granulovacuolaire degeneratie Type: general – SubjectFull: Alzheimer's disease Type: general – SubjectFull: Cerebral amyloid angiopathy Type: general – SubjectFull: Postmortem human brain Type: general – SubjectFull: Laserdissection Type: general – SubjectFull: Amyloid beta Type: general – SubjectFull: Granulovacuolar degeneration Type: general Titles: – TitleFull: Proteomic dissection of Alzheimer’s disease pathology Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hondius, David Carolus IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2022 Identifiers: – Type: issn-locals Value: edsbas – Type: issn-locals Value: edsbas.oa Titles: – TitleFull: Hondius, D C 2022, 'Proteomic dissection of Alzheimer’s disease pathology', Dr., Vrije Universiteit Amsterdam, s.l Type: main |
| ResultId | 1 |