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Neurodegenerative Diseases: The Value of Early Predictive End Points

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Title: Neurodegenerative Diseases: The Value of Early Predictive End Points
Authors: Janicki Hsieh, Sarah, Alexopoulou, Zoi, Mehrotra, Nitin, Struyk, Arie, Stoch, S. Aubrey
Source: Clinical Pharmacology & Therapeutics ; volume 111, issue 4, page 835-839 ; ISSN 0009-9236 1532-6535
Publisher Information: Wiley
Publication Year: 2022
Collection: Wiley Online Library (Open Access Articles via Crossref)
Description: Use of early predictive biomarkers of neurodegenerative disease in phase I clinical trials may improve the translation of novel drug therapies from preclinical development through late‐stage studies. This article provides a categorical summary of promising biomarker approaches or clinical end points in molecular, cellular, metabolic, electrophysiological, or clinical function that can be used to predict or quantify the progression of neurodegenerative disorders and guide program support.
Document Type: article in journal/newspaper
Language: English
DOI: 10.1002/cpt.2544
Availability: https://doi.org/10.1002/cpt.2544
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2544
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https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2544
Rights: http://onlinelibrary.wiley.com/termsAndConditions#vor
Accession Number: edsbas.F0F995E9
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  Data: Clinical Pharmacology & Therapeutics ; volume 111, issue 4, page 835-839 ; ISSN 0009-9236 1532-6535
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  Data: Use of early predictive biomarkers of neurodegenerative disease in phase I clinical trials may improve the translation of novel drug therapies from preclinical development through late‐stage studies. This article provides a categorical summary of promising biomarker approaches or clinical end points in molecular, cellular, metabolic, electrophysiological, or clinical function that can be used to predict or quantify the progression of neurodegenerative disorders and guide program support.
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