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Effects of melengesterol acetate on inflammatory response during Mannheimia haemolytica challenge

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Effects of melengesterol acetate on inflammatory response during Mannheimia haemolytica challenge
Συγγραφείς: Corrigan, M.E., Drouillard, James S., Spire, M.F., Moser, Daniel W., Higgins, James J., Loe, E.R., Fox, J.T., Minton, J. Ernest, Depenbusch, Brandon E.
Πηγή: Kansas Agricultural Experiment Station Research Reports
Στοιχεία εκδότη: New Prairie Press
Έτος έκδοσης: 2005
Συλλογή: New Prairie Press - Open Access Scholarly Journals
Θεματικοί όροι: Cattlemen's Day, Kansas Agricultural Experiment Station contribution, no. 05-144-S, Report of progress (Kansas State University. Agricultural Experiment Station and Cooperative Extension Service), Beef, Melengesterol acetate, Mannheimia haemolytica, Animal Sciences, Other Animal Sciences
Time: 2005, 943
Περιγραφή: Previous trials conducted at Kansas State University demonstrated that melengesterol acetate (MGA) increased growth rates and tended to reduce chronic sickness in heifers naturally challenged with undifferentiated bovine respiratory disease. Our study was conducted to gain further insight into the mode of action of MGA. Crossbred heifers (n=47; 511 lb) were used to evaluate effects of MGA on lung pathology and markers of inflammation in cattle after an intrabronchial Mannheimia haemolytica challenge. On day 0, cattle were assigned to diets (54% concentrate) that provided 0 or 0.5 mg MGA per heifer daily. On day 14 each heifer was intrabronchially inoculated with M. haemolytica. Blood samples were collected from each heifer immediately before inoculation and 12, 24, 48, 72, 96, 120, and 138 hours after inoculation. Heifers were then euthanized for postmortem examination. After the challenge, heifers fed MGA had greater numbers of neutrophils and white blood cells, as well as greater serum haptoglobin and fibrinogen concentrations. The incidence of post-challenge lung lesions was greater in heifers fed MGA, and lung lesion scores tended to be more severe in heifers fed MGA, compared with those of controls. These data indicate that MGA does not reduce inflammation in heifers 138 hours after M. haemolytica challenge, suggesting that there are other modes of action for the beneficial effects on growth and reduction of chronicity in feedlot heifers.
Τύπος εγγράφου: text
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Γλώσσα: unknown
Relation: https://newprairiepress.org/kaesrr/vol0/iss1/182; https://newprairiepress.org/context/kaesrr/article/1585/viewcontent/cattle05pg30_34.pdf
DOI: 10.4148/2378-5977.1585
Διαθεσιμότητα: https://newprairiepress.org/kaesrr/vol0/iss1/182
https://doi.org/10.4148/2378-5977.1585
https://newprairiepress.org/context/kaesrr/article/1585/viewcontent/cattle05pg30_34.pdf
Rights: http://creativecommons.org/licenses/by/4.0/
Αριθμός Καταχώρησης: edsbas.ECF2B518
Βάση Δεδομένων: BASE
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  Data: Effects of melengesterol acetate on inflammatory response during Mannheimia haemolytica challenge
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  Data: <searchLink fieldCode="AR" term="%22Corrigan%2C+M%2EE%2E%22">Corrigan, M.E.</searchLink><br /><searchLink fieldCode="AR" term="%22Drouillard%2C+James+S%2E%22">Drouillard, James S.</searchLink><br /><searchLink fieldCode="AR" term="%22Spire%2C+M%2EF%2E%22">Spire, M.F.</searchLink><br /><searchLink fieldCode="AR" term="%22Moser%2C+Daniel+W%2E%22">Moser, Daniel W.</searchLink><br /><searchLink fieldCode="AR" term="%22Higgins%2C+James+J%2E%22">Higgins, James J.</searchLink><br /><searchLink fieldCode="AR" term="%22Loe%2C+E%2ER%2E%22">Loe, E.R.</searchLink><br /><searchLink fieldCode="AR" term="%22Fox%2C+J%2ET%2E%22">Fox, J.T.</searchLink><br /><searchLink fieldCode="AR" term="%22Minton%2C+J%2E+Ernest%22">Minton, J. Ernest</searchLink><br /><searchLink fieldCode="AR" term="%22Depenbusch%2C+Brandon+E%2E%22">Depenbusch, Brandon E.</searchLink>
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  Data: 2005
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  Data: <searchLink fieldCode="DE" term="%22Cattlemen's+Day%22">Cattlemen's Day</searchLink><br /><searchLink fieldCode="DE" term="%22Kansas+Agricultural+Experiment+Station+contribution%22">Kansas Agricultural Experiment Station contribution</searchLink><br /><searchLink fieldCode="DE" term="%22no%2E+05-144-S%22">no. 05-144-S</searchLink><br /><searchLink fieldCode="DE" term="%22Report+of+progress+%28Kansas+State+University%2E+Agricultural+Experiment+Station+and+Cooperative+Extension+Service%29%22">Report of progress (Kansas State University. Agricultural Experiment Station and Cooperative Extension Service)</searchLink><br /><searchLink fieldCode="DE" term="%22Beef%22">Beef</searchLink><br /><searchLink fieldCode="DE" term="%22Melengesterol+acetate%22">Melengesterol acetate</searchLink><br /><searchLink fieldCode="DE" term="%22Mannheimia+haemolytica%22">Mannheimia haemolytica</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+Sciences%22">Animal Sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Other+Animal+Sciences%22">Other Animal Sciences</searchLink>
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  Data: 2005<br />943
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  Data: Previous trials conducted at Kansas State University demonstrated that melengesterol acetate (MGA) increased growth rates and tended to reduce chronic sickness in heifers naturally challenged with undifferentiated bovine respiratory disease. Our study was conducted to gain further insight into the mode of action of MGA. Crossbred heifers (n=47; 511 lb) were used to evaluate effects of MGA on lung pathology and markers of inflammation in cattle after an intrabronchial Mannheimia haemolytica challenge. On day 0, cattle were assigned to diets (54% concentrate) that provided 0 or 0.5 mg MGA per heifer daily. On day 14 each heifer was intrabronchially inoculated with M. haemolytica. Blood samples were collected from each heifer immediately before inoculation and 12, 24, 48, 72, 96, 120, and 138 hours after inoculation. Heifers were then euthanized for postmortem examination. After the challenge, heifers fed MGA had greater numbers of neutrophils and white blood cells, as well as greater serum haptoglobin and fibrinogen concentrations. The incidence of post-challenge lung lesions was greater in heifers fed MGA, and lung lesion scores tended to be more severe in heifers fed MGA, compared with those of controls. These data indicate that MGA does not reduce inflammation in heifers 138 hours after M. haemolytica challenge, suggesting that there are other modes of action for the beneficial effects on growth and reduction of chronicity in feedlot heifers.
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