Academic Journal
Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression.
| Τίτλος: | Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression. |
|---|---|
| Συγγραφείς: | Vionnet, J., Torres-Yaguana, J., Miquel, R., Abraldes, J.G., Wall, J., Kodela, E., Lozano, J.J., Ruiz, P., Navasa, M., Marshall, A., Nevens, F., Gelson, W., Leithead, J., Masson, S., Jaeckel, E., Taubert, R., Tachtatzis, P., Eurich, D., Simpson, K.J., Bonaccorsi-Riani, E., Ferguson, J., Quaglia, A., Demetris, A.J., Lesniak, A.J., Elstad, M., Delord, M., Douiri, A., Rebollo-Mesa, I., Martinez-Llordella, M., Silva, JAF, Markmann, J.F., Sánchez-Fueyo, A. |
| Έτος έκδοσης: | 2025 |
| Συλλογή: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| Θεματικοί όροι: | Adult, Aged, Female, Humans, Male, Middle Aged, Biomarkers/metabolism, Biomarkers/analysis, Follow-Up Studies, Graft Rejection/diagnosis, Graft Rejection/etiology, Graft Rejection/prevention & control, Graft Survival, Immunosuppression Therapy, Immunosuppressive Agents/therapeutic use, Liver/metabolism, Liver Transplantation/adverse effects, Prognosis, Prospective Studies, Transplant Recipients, Transplantation Tolerance, DSA, LT, biomarker, gene-expression profiling, immunosuppression minimization, tolerance |
| Περιγραφή: | The maintenance of stable allograft status in the absence of immunosuppression (IS), known as operational tolerance, can be achieved in a small proportion of liver transplant recipients, but we lack reliable tools to predict its spontaneous development. We conducted a prospective, multicenter, biomarker-strategy design, IS withdrawal clinical trial to determine the utility of a predictive biomarker of operational tolerance. The biomarker test, originally identified in a patient cohort with high operational tolerance prevalence, consisted of a 5-gene transcriptional signature measured in liver tissue collected before initiating IS weaning. One hundred sixteen adult stable liver transplant recipients were randomized 1:1 to either arm A (IS withdrawal regardless of biomarker status) or arm B (IS withdrawal in biomarker-positive recipients). Immunosuppression withdrawal was initiated in 82 participants, rejection occurred in 54 (67.5%), and successful discontinuation of IS was achieved in 22 (27.5%), but only 13 (16.3%) met operational tolerance histologic criteria (10 in arm A; 3 in arm B). The biomarker test did not yield useful information in selecting patients able to successfully discontinue IS. Operational tolerance was associated with time posttransplant, recipient age, presence of circulating exhausted CD8 + T cells, and a reduced number of immune synapses within the graft. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 1600-6143 |
| Relation: | American Journal of Transplantation; https://iris.unil.ch/handle/iris/261568; serval:BIB_ADA5B15384A1; 001483870500001 |
| DOI: | 10.1016/j.ajt.2024.12.002 |
| Διαθεσιμότητα: | https://iris.unil.ch/handle/iris/261568 https://doi.org/10.1016/j.ajt.2024.12.002 |
| Αριθμός Καταχώρησης: | edsbas.EC04EB64 |
| Βάση Δεδομένων: | BASE |
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