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Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis

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Τίτλος: Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis
Συγγραφείς: Costas-Carrera, A., Verdolini, N., Garcia-Rizo, C., Mezquida, G., Janssen, J., Valli, I., Corripio, I., Sanchez-Torres, A.M., Bioque, M., Lobo, A., Gonzalez-Pinto, A., Rapado-Castro, M., Vieta, E., De La Serna, H., Mane, A., Roldan, A., Crossley Karmelic, Nicolas Andres, Penades, R., Cuesta, M.J., Parellada, M.
Συνεισφορές: PEPs group
Έτος έκδοσης: 2024
Συλλογή: Pontificia Universidad Católica de Chile: Repositorio UC
Θεματικοί όροι: Cognitive impairment, Delivery, First episode psychosis, Obstetric complications, Ventricle enlargement, Verbal memory, Medicina y salud, 03 Good health and well-being, 03 Salud y bienestar
Time: 610
Περιγραφή: Published by Cambridge University Press.Background Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been associated with an increased risk of developing psychosis but also with cognitive impairment and brain structure abnormalities. Difficulties during delivery are associated with a higher risk of birth asphyxia leading to brain structural abnormalities, such as ventriculomegaly, which has been related to cognitive disturbances. Methods We examined differences in ventricular size between 142 FEP patients and 123 healthy control participants using magnetic resonance imaging. Obstetric complications were evaluated using the Lewis-Murray scale. We examined the impact of obstetric difficulties during delivery on ventricle size as well as the possible relationship between ventricle size and cognitive impairment in both groups. Results FEP patients displayed significantly larger third ventricle size compared with healthy controls. Third ventricle enlargement was associated with diagnosis (higher volume in patients), with difficulties during delivery (higher volume in subjects with difficulties), and was highest in patients with difficulties during delivery. Verbal memory was significantly associated with third ventricle to brain ratio. Conclusions Our results suggest that difficulties during delivery might be significant contributors to the ventricular enlargement historically described in schizophrenia. Thus, obstetric complications may contribute to the development of psychosis through changes in brain architecture.
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: 11 páginas; application/pdf
Γλώσσα: English
ISBN: 978-85-17-91098-2
85-17-91098-2
Relation: SCOPUS_ID:85179109824; https://doi.org/10.1017/S0033291723003185; https://repositorio.uc.cl/handle/11534/86479; WOS:001113459200001
DOI: 10.1017/S0033291723003185
Διαθεσιμότητα: https://repositorio.uc.cl/handle/11534/86479
https://doi.org/10.1017/S0033291723003185
Rights: acceso abierto ; CC BY 4.0 DEED Atribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/deed.en
Αριθμός Καταχώρησης: edsbas.EB659194
Βάση Δεδομένων: BASE
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  Data: Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis
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  Data: <searchLink fieldCode="AR" term="%22Costas-Carrera%2C+A%2E%22">Costas-Carrera, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Verdolini%2C+N%2E%22">Verdolini, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Garcia-Rizo%2C+C%2E%22">Garcia-Rizo, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Mezquida%2C+G%2E%22">Mezquida, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Janssen%2C+J%2E%22">Janssen, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Valli%2C+I%2E%22">Valli, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Corripio%2C+I%2E%22">Corripio, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Sanchez-Torres%2C+A%2EM%2E%22">Sanchez-Torres, A.M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bioque%2C+M%2E%22">Bioque, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Lobo%2C+A%2E%22">Lobo, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Gonzalez-Pinto%2C+A%2E%22">Gonzalez-Pinto, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Rapado-Castro%2C+M%2E%22">Rapado-Castro, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Vieta%2C+E%2E%22">Vieta, E.</searchLink><br /><searchLink fieldCode="AR" term="%22De+La+Serna%2C+H%2E%22">De La Serna, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Mane%2C+A%2E%22">Mane, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Roldan%2C+A%2E%22">Roldan, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Crossley+Karmelic%2C+Nicolas+Andres%22">Crossley Karmelic, Nicolas Andres</searchLink><br /><searchLink fieldCode="AR" term="%22Penades%2C+R%2E%22">Penades, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Cuesta%2C+M%2EJ%2E%22">Cuesta, M.J.</searchLink><br /><searchLink fieldCode="AR" term="%22Parellada%2C+M%2E%22">Parellada, M.</searchLink>
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  Data: 2024
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  Data: Pontificia Universidad Católica de Chile: Repositorio UC
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  Data: <searchLink fieldCode="DE" term="%22Cognitive+impairment%22">Cognitive impairment</searchLink><br /><searchLink fieldCode="DE" term="%22Delivery%22">Delivery</searchLink><br /><searchLink fieldCode="DE" term="%22First+episode+psychosis%22">First episode psychosis</searchLink><br /><searchLink fieldCode="DE" term="%22Obstetric+complications%22">Obstetric complications</searchLink><br /><searchLink fieldCode="DE" term="%22Ventricle+enlargement%22">Ventricle enlargement</searchLink><br /><searchLink fieldCode="DE" term="%22Verbal+memory%22">Verbal memory</searchLink><br /><searchLink fieldCode="DE" term="%22Medicina+y+salud%22">Medicina y salud</searchLink><br /><searchLink fieldCode="DE" term="%2203+Good+health+and+well-being%22">03 Good health and well-being</searchLink><br /><searchLink fieldCode="DE" term="%2203+Salud+y+bienestar%22">03 Salud y bienestar</searchLink>
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  Data: Published by Cambridge University Press.Background Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been associated with an increased risk of developing psychosis but also with cognitive impairment and brain structure abnormalities. Difficulties during delivery are associated with a higher risk of birth asphyxia leading to brain structural abnormalities, such as ventriculomegaly, which has been related to cognitive disturbances. Methods We examined differences in ventricular size between 142 FEP patients and 123 healthy control participants using magnetic resonance imaging. Obstetric complications were evaluated using the Lewis-Murray scale. We examined the impact of obstetric difficulties during delivery on ventricle size as well as the possible relationship between ventricle size and cognitive impairment in both groups. Results FEP patients displayed significantly larger third ventricle size compared with healthy controls. Third ventricle enlargement was associated with diagnosis (higher volume in patients), with difficulties during delivery (higher volume in subjects with difficulties), and was highest in patients with difficulties during delivery. Verbal memory was significantly associated with third ventricle to brain ratio. Conclusions Our results suggest that difficulties during delivery might be significant contributors to the ventricular enlargement historically described in schizophrenia. Thus, obstetric complications may contribute to the development of psychosis through changes in brain architecture.
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  Data: 10.1017/S0033291723003185
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  Data: acceso abierto ; CC BY 4.0 DEED Atribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/deed.en
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