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Early Physiological and Biochemical Responses to Short-Term Oral Exposure to Microplastic Particles in Male Wistar Rats

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Title: Early Physiological and Biochemical Responses to Short-Term Oral Exposure to Microplastic Particles in Male Wistar Rats
Authors: Zoran Stojanović, Dunja Drakulić, Jelena Martinović, Ana Todorović, Filip Veljković, Nenad Filipović, Ivana Guševac Stojanović
Source: Microplastics ; Volume 5 ; Issue 1 ; Pages: 54
Publisher Information: Multidisciplinary Digital Publishing Institute
Publication Year: 2026
Collection: MDPI Open Access Publishing
Subject Terms: microplastic particles (MPs), poly (ethylene terephthalate) (PET), single treatment, overall health indicators, serum biochemical markers, Wistar rats, microplastic size, machine-learning tools, acute
Description: While various disturbances in organisms have been reported following long-term oral exposure to small plastic particles (microplastic particles, MPs), the effects of acute, short-term encounters remain underrepresented in scientific research. In this study, adult male Wistar rats were orally gavaged with MPs of three different sizes (~41 µm, 70 µm, or 106 µm; dose: 35 mg/kg), originating from poly(ethylene terephthalate) (PET) bottles. Twenty-four hours post-exposure, the impact on overall health indicators, including food and water intake, sensorimotor function and clinical signs of toxicity, in addition to serum biochemical markers related to organ function and oxidative stress, were assessed. Although no overt sensorimotor impairments or visible toxicity signs were observed in all MPs-treated groups, several investigated biochemical parameters were significantly altered. Water intake was also modified, whereas reduced food intake occurred only in the group treated with median-sized MPs, suggesting that acute exposure to MPs can lead to early physiological and biochemical responses. The obtained results, compared to the data extracted by using machine-learning (ML) tools and GPT-5 model within the available literature, highlighted the importance of investigating the acute effects of MPs, which may precede or contribute to long-term health consequences.
Document Type: Thesis
File Description: application/pdf
Language: English
Relation: https://dx.doi.org/10.3390/microplastics5010054
DOI: 10.3390/microplastics5010054
Availability: https://doi.org/10.3390/microplastics5010054
Rights: https://creativecommons.org/licenses/by/4.0/
Accession Number: edsbas.E9677510
Database: BASE
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  – Url: https://doi.org/10.3390/microplastics5010054#
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  Data: Early Physiological and Biochemical Responses to Short-Term Oral Exposure to Microplastic Particles in Male Wistar Rats
– Name: Author
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  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Zoran+Stojanović%22">Zoran Stojanović</searchLink><br /><searchLink fieldCode="AR" term="%22Dunja+Drakulić%22">Dunja Drakulić</searchLink><br /><searchLink fieldCode="AR" term="%22Jelena+Martinović%22">Jelena Martinović</searchLink><br /><searchLink fieldCode="AR" term="%22Ana+Todorović%22">Ana Todorović</searchLink><br /><searchLink fieldCode="AR" term="%22Filip+Veljković%22">Filip Veljković</searchLink><br /><searchLink fieldCode="AR" term="%22Nenad+Filipović%22">Nenad Filipović</searchLink><br /><searchLink fieldCode="AR" term="%22Ivana+Guševac+Stojanović%22">Ivana Guševac Stojanović</searchLink>
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  Data: Microplastics ; Volume 5 ; Issue 1 ; Pages: 54
– Name: Publisher
  Label: Publisher Information
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  Data: Multidisciplinary Digital Publishing Institute
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  Data: 2026
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  Data: MDPI Open Access Publishing
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  Data: <searchLink fieldCode="DE" term="%22microplastic+particles+%28MPs%29%22">microplastic particles (MPs)</searchLink><br /><searchLink fieldCode="DE" term="%22poly+%28ethylene+terephthalate%29+%28PET%29%22">poly (ethylene terephthalate) (PET)</searchLink><br /><searchLink fieldCode="DE" term="%22single+treatment%22">single treatment</searchLink><br /><searchLink fieldCode="DE" term="%22overall+health+indicators%22">overall health indicators</searchLink><br /><searchLink fieldCode="DE" term="%22serum+biochemical+markers%22">serum biochemical markers</searchLink><br /><searchLink fieldCode="DE" term="%22Wistar+rats%22">Wistar rats</searchLink><br /><searchLink fieldCode="DE" term="%22microplastic+size%22">microplastic size</searchLink><br /><searchLink fieldCode="DE" term="%22machine-learning+tools%22">machine-learning tools</searchLink><br /><searchLink fieldCode="DE" term="%22acute%22">acute</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: While various disturbances in organisms have been reported following long-term oral exposure to small plastic particles (microplastic particles, MPs), the effects of acute, short-term encounters remain underrepresented in scientific research. In this study, adult male Wistar rats were orally gavaged with MPs of three different sizes (~41 µm, 70 µm, or 106 µm; dose: 35 mg/kg), originating from poly(ethylene terephthalate) (PET) bottles. Twenty-four hours post-exposure, the impact on overall health indicators, including food and water intake, sensorimotor function and clinical signs of toxicity, in addition to serum biochemical markers related to organ function and oxidative stress, were assessed. Although no overt sensorimotor impairments or visible toxicity signs were observed in all MPs-treated groups, several investigated biochemical parameters were significantly altered. Water intake was also modified, whereas reduced food intake occurred only in the group treated with median-sized MPs, suggesting that acute exposure to MPs can lead to early physiological and biochemical responses. The obtained results, compared to the data extracted by using machine-learning (ML) tools and GPT-5 model within the available literature, highlighted the importance of investigating the acute effects of MPs, which may precede or contribute to long-term health consequences.
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        Value: 10.3390/microplastics5010054
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      – Text: English
    Subjects:
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        Type: general
      – SubjectFull: poly (ethylene terephthalate) (PET)
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      – SubjectFull: serum biochemical markers
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      – SubjectFull: Wistar rats
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      – SubjectFull: microplastic size
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      – TitleFull: Early Physiological and Biochemical Responses to Short-Term Oral Exposure to Microplastic Particles in Male Wistar Rats
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              Type: published
              Y: 2026
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