Academic Journal
Physiological declines in sex steroid exposure in relation to changes in body composition in healthy men—a prospective cohort study
| Τίτλος: | Physiological declines in sex steroid exposure in relation to changes in body composition in healthy men—a prospective cohort study |
|---|---|
| Συγγραφείς: | Banica, Thiberiu, Verroken, Charlotte, Reyns, Tim, T’Sjoen, Guy, Fiers, Tom, Kaufman, Jean-Marc, Lapauw, Bruno |
| Συνεισφορές: | Fonds Wetenschappelijk Onderzoek |
| Πηγή: | European Journal of Endocrinology ; volume 188, issue 6, page 510-518 ; ISSN 0804-4643 1479-683X |
| Στοιχεία εκδότη: | Oxford University Press (OUP) |
| Έτος έκδοσης: | 2023 |
| Περιγραφή: | Objective Androgen levels decline from early adulthood and decreases are steeper in men with increasing body mass index. It is, however, unclear to what extent changes in other indices of body composition and metabolism associate with changes in sex steroid levels in healthy men. Therefore, this study investigated longitudinal changes in body composition and metabolic health in relation to sex steroid levels in healthy adult men. Design This is a longitudinal, population-based study. A total of 676 healthy men aged 24-46 years were measured at baseline and after ±12 years. Methods Serum sex hormone-binding globulin (SHBG) was measured by immunoassay, testosterone (T), estradiol (E2), and dihydrotestosterone byliquid chromatography with tandem mass spectrometry (LC-MS/MS), calculated free T and calculated free E2 (cFE2), and homeostasis model assessment for insulin resistance (HOMA-IR) were calculated. Grip strength was measured by hand-grip dynamometry. Body composition was determined using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. Results Mean fat mass (FM), lean mass (LM), and HOMA-IR increased (all P < .001). Decreasing androgen and SHBG levels was associated with increasing FM, whereas decreasing (cF)E2 levels were associated with decreasing FM (all P < .005). Decreasing (cF)E2 levels and increasing SHBG levels associated with decreasing LM (all P < .002). Changes in sex steroid levels and HOMA-IR or grip strength were not interrelated. Conclusion Aging leads to increases in FM indices and insulin resistance, whereas changes in parameters of LM are less unequivocal. In healthy adult men, physiological changes in sex steroid exposure clearly correlate with changes in adiposity but not so with lean mass, insulin resistance, or grip strength. Clinical Trial The SIBEX study was registered on ClinicalTrials.gov (#NVT02997033). |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| DOI: | 10.1093/ejendo/lvad059 |
| DOI: | 10.1093/ejendo/lvad059/50537830/lvad059.pdf |
| Διαθεσιμότητα: | https://doi.org/10.1093/ejendo/lvad059 https://academic.oup.com/ejendo/advance-article-pdf/doi/10.1093/ejendo/lvad059/50537830/lvad059.pdf https://academic.oup.com/ejendo/article-pdf/188/6/510/50735508/lvad059.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| Αριθμός Καταχώρησης: | edsbas.E9244665 |
| Βάση Δεδομένων: | BASE |
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