Academic Journal
Changes in serum testosterone and adrenal androgen levels in transgender women with and without gonadectomy
| Τίτλος: | Changes in serum testosterone and adrenal androgen levels in transgender women with and without gonadectomy |
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| Συγγραφείς: | Collet, Sarah, Gieles, Noor, Wiepjes, Chantal M., Heijboer, Annemieke C., Reyns, Tim, Fiers, Tom, Lapauw, Bruno, den Heijer, Martin, T'Sjoen, Guy |
| Πηγή: | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM ; ISSN: 0021-972X ; ISSN: 1945-7197 |
| Έτος έκδοσης: | 2023 |
| Συλλογή: | Ghent University Academic Bibliography |
| Θεματικοί όροι: | Medicine and Health Sciences, Social Sciences, gonadectomy, testosterone, androgens, liquid chromatographytandem mass spectrometry, gender-affirming hormone therapy, transgender women |
| Περιγραφή: | Background Initiating feminizing gender-affirming hormone therapy (GAHT) in transgender women causes a steep decline in serum testosterone. It is unknown if testosterone concentrations change further and whether adrenal androgen levels change during feminizing GAHT and after gonadectomy. This limits clinical decision making in transgender women with symptoms attributed to GAHT or gonadectomy. Methods Transgender women (n = 275) initiating estradiol and cyproterone acetate (CPA) were included at baseline, and had follow-up visits after 3 months, 12 months, and 2 to 4 years. During follow-up, 49.5% of transgender women underwent a gonadectomy. Total testosterone (TT), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), and androstenedione (A4) were measured using liquid chromatography tandem mass spectrometry. Results After 3 months of GAHT, mean TT, calculated free testosterone (cFT), and A4 decreased by 18.4 nmol/L (95% CI, -19.4 to -17.4, P < 0.001 [ie, -97.1%]), 383 pmol/L (95% CI, -405 to -362, P < 0.001 [ie, -98.3%]), and 1.2 nmol/L (95% CI, -1.4 to -1.0, P < 0.001 [ie, -36.5%]), respectively, and remained stable thereafter. DHEA and DHEAS decreased by 7.4 nmol/L (95% CI, -9.7 to -5.1 [ie, -28.0%]) and 1.8 mu mol/L (95% CI, -2.2 to -1.4 [ie, -20.1%]), respectively, after 1 year and did not change thereafter. After gonadectomy, CPA therapy is stopped, which induced no further change in TT, cFT, DHEA, DHEAS, and A4 compared with those who did not undergo gonadectomy. Conclusions Our findings confirm that after an initial drop, testosterone levels in transgender women remain stable. Adrenal androgens decrease in the first year of CPA and estrogen supplementation and remain unchanged after gonadectomy. Androgens did not change after gonadectomy and cessation of CPA. Correlates with clinical symptoms remain to be elucidated. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | https://biblio.ugent.be/publication/01GT969WVBMRV6WK0Q1S8RS2TQ; https://doi.org/10.1210/clinem/dgac576; https://biblio.ugent.be/publication/01GT969WVBMRV6WK0Q1S8RS2TQ/file/01GT96DMFENNQ0HVKP9BSEBCX6 |
| DOI: | 10.1210/clinem/dgac576 |
| Διαθεσιμότητα: | https://biblio.ugent.be/publication/01GT969WVBMRV6WK0Q1S8RS2TQ https://hdl.handle.net/1854/LU-01GT969WVBMRV6WK0Q1S8RS2TQ https://doi.org/10.1210/clinem/dgac576 https://biblio.ugent.be/publication/01GT969WVBMRV6WK0Q1S8RS2TQ/file/01GT96DMFENNQ0HVKP9BSEBCX6 |
| Rights: | info:eu-repo/semantics/openAccess |
| Αριθμός Καταχώρησης: | edsbas.E37F385A |
| Βάση Δεδομένων: | BASE |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://biblio.ugent.be/publication/01GT969WVBMRV6WK0Q1S8RS2TQ# Name: EDS - BASE (ns324271) Category: fullText Text: View record from BASE |
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| Header | DbId: edsbas DbLabel: BASE An: edsbas.E37F385A RelevancyScore: 926 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 926.330688476563 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Changes in serum testosterone and adrenal androgen levels in transgender women with and without gonadectomy – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Collet%2C+Sarah%22">Collet, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Gieles%2C+Noor%22">Gieles, Noor</searchLink><br /><searchLink fieldCode="AR" term="%22Wiepjes%2C+Chantal+M%2E%22">Wiepjes, Chantal M.</searchLink><br /><searchLink fieldCode="AR" term="%22Heijboer%2C+Annemieke+C%2E%22">Heijboer, Annemieke C.</searchLink><br /><searchLink fieldCode="AR" term="%22Reyns%2C+Tim%22">Reyns, Tim</searchLink><br /><searchLink fieldCode="AR" term="%22Fiers%2C+Tom%22">Fiers, Tom</searchLink><br /><searchLink fieldCode="AR" term="%22Lapauw%2C+Bruno%22">Lapauw, Bruno</searchLink><br /><searchLink fieldCode="AR" term="%22den+Heijer%2C+Martin%22">den Heijer, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22T'Sjoen%2C+Guy%22">T'Sjoen, Guy</searchLink> – Name: TitleSource Label: Source Group: Src Data: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM ; ISSN: 0021-972X ; ISSN: 1945-7197 – Name: DatePubCY Label: Publication Year Group: Date Data: 2023 – Name: Subset Label: Collection Group: HoldingsInfo Data: Ghent University Academic Bibliography – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Medicine+and+Health+Sciences%22">Medicine and Health Sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Social+Sciences%22">Social Sciences</searchLink><br /><searchLink fieldCode="DE" term="%22gonadectomy%22">gonadectomy</searchLink><br /><searchLink fieldCode="DE" term="%22testosterone%22">testosterone</searchLink><br /><searchLink fieldCode="DE" term="%22androgens%22">androgens</searchLink><br /><searchLink fieldCode="DE" term="%22liquid+chromatographytandem+mass+spectrometry%22">liquid chromatographytandem mass spectrometry</searchLink><br /><searchLink fieldCode="DE" term="%22gender-affirming+hormone+therapy%22">gender-affirming hormone therapy</searchLink><br /><searchLink fieldCode="DE" term="%22transgender+women%22">transgender women</searchLink> – Name: Abstract Label: Description Group: Ab Data: Background Initiating feminizing gender-affirming hormone therapy (GAHT) in transgender women causes a steep decline in serum testosterone. It is unknown if testosterone concentrations change further and whether adrenal androgen levels change during feminizing GAHT and after gonadectomy. This limits clinical decision making in transgender women with symptoms attributed to GAHT or gonadectomy. Methods Transgender women (n = 275) initiating estradiol and cyproterone acetate (CPA) were included at baseline, and had follow-up visits after 3 months, 12 months, and 2 to 4 years. During follow-up, 49.5% of transgender women underwent a gonadectomy. Total testosterone (TT), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), and androstenedione (A4) were measured using liquid chromatography tandem mass spectrometry. Results After 3 months of GAHT, mean TT, calculated free testosterone (cFT), and A4 decreased by 18.4 nmol/L (95% CI, -19.4 to -17.4, P < 0.001 [ie, -97.1%]), 383 pmol/L (95% CI, -405 to -362, P < 0.001 [ie, -98.3%]), and 1.2 nmol/L (95% CI, -1.4 to -1.0, P < 0.001 [ie, -36.5%]), respectively, and remained stable thereafter. DHEA and DHEAS decreased by 7.4 nmol/L (95% CI, -9.7 to -5.1 [ie, -28.0%]) and 1.8 mu mol/L (95% CI, -2.2 to -1.4 [ie, -20.1%]), respectively, after 1 year and did not change thereafter. After gonadectomy, CPA therapy is stopped, which induced no further change in TT, cFT, DHEA, DHEAS, and A4 compared with those who did not undergo gonadectomy. Conclusions Our findings confirm that after an initial drop, testosterone levels in transgender women remain stable. Adrenal androgens decrease in the first year of CPA and estrogen supplementation and remain unchanged after gonadectomy. Androgens did not change after gonadectomy and cessation of CPA. Correlates with clinical symptoms remain to be elucidated. – Name: TypeDocument Label: Document Type Group: TypDoc Data: article in journal/newspaper – Name: Format Label: File Description Group: SrcInfo Data: application/pdf – Name: Language Label: Language Group: Lang Data: English – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: https://biblio.ugent.be/publication/01GT969WVBMRV6WK0Q1S8RS2TQ; https://doi.org/10.1210/clinem/dgac576; https://biblio.ugent.be/publication/01GT969WVBMRV6WK0Q1S8RS2TQ/file/01GT96DMFENNQ0HVKP9BSEBCX6 – Name: DOI Label: DOI Group: ID Data: 10.1210/clinem/dgac576 – Name: URL Label: Availability Group: URL Data: https://biblio.ugent.be/publication/01GT969WVBMRV6WK0Q1S8RS2TQ<br />https://hdl.handle.net/1854/LU-01GT969WVBMRV6WK0Q1S8RS2TQ<br />https://doi.org/10.1210/clinem/dgac576<br />https://biblio.ugent.be/publication/01GT969WVBMRV6WK0Q1S8RS2TQ/file/01GT96DMFENNQ0HVKP9BSEBCX6 – Name: Copyright Label: Rights Group: Cpyrght Data: info:eu-repo/semantics/openAccess – Name: AN Label: Accession Number Group: ID Data: edsbas.E37F385A |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.E37F385A |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1210/clinem/dgac576 Languages: – Text: English Subjects: – SubjectFull: Medicine and Health Sciences Type: general – SubjectFull: Social Sciences Type: general – SubjectFull: gonadectomy Type: general – SubjectFull: testosterone Type: general – SubjectFull: androgens Type: general – SubjectFull: liquid chromatographytandem mass spectrometry Type: general – SubjectFull: gender-affirming hormone therapy Type: general – SubjectFull: transgender women Type: general Titles: – TitleFull: Changes in serum testosterone and adrenal androgen levels in transgender women with and without gonadectomy Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Collet, Sarah – PersonEntity: Name: NameFull: Gieles, Noor – PersonEntity: Name: NameFull: Wiepjes, Chantal M. – PersonEntity: Name: NameFull: Heijboer, Annemieke C. – PersonEntity: Name: NameFull: Reyns, Tim – PersonEntity: Name: NameFull: Fiers, Tom – PersonEntity: Name: NameFull: Lapauw, Bruno – PersonEntity: Name: NameFull: den Heijer, Martin – PersonEntity: Name: NameFull: T'Sjoen, Guy IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2023 Identifiers: – Type: issn-locals Value: edsbas – Type: issn-locals Value: edsbas.oa Titles: – TitleFull: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM ; ISSN: 0021-972X ; ISSN: 1945-7197 Type: main |
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