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Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

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Τίτλος: Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
Συγγραφείς: García-Marín, L., Campos, A., Diaz-Torres, S., Rabinowitz, J., Ceja, Z., Mitchell, B., Grasby, K., Thorp, J., Agartz, I., Alhusaini, S., Ames, D., Amouyel, P., Andreassen, O., Arfanakis, K., Arias-Vasquez, A., Armstrong, N., Athanasiu, L., Bastin, M., Beiser, A., Bennett, D., Bis, J., Boks, M., Boomsma, D., Brodaty, H., Brouwer, R., Buitelaar, J., Burkhardt, R., Cahn, W., Calhoun, V., Carmichael, O., Chakravarty, M., Chen, Q., Ching, C., Cichon, S., Crespo-Facorro, B., Crivello, F., Dale, A., Smith, G., de Geus, E., De Jager, P., de Zubicaray, G., Debette, S., DeCarli, C., Depondt, C., Desrivières, S., Djurovic, S., Ehrlich, S., Erk, S., Espeseth, T., Fernández, G., Filippi, I., Fisher, S., Fleischman, D., Fletcher, E., Fornage, M., Forstner, A., Francks, C., Franke, B., Ge, T., Goldman, A., Grabe, H., Green, R., Grimm, O., Groenewold, N., Gruber, O., Gudnason, V., Håberg, A., Haukvik, U., Heinz, A., Hibar, D., Hilal, S., Himali, J., Ho, B., Hoehn, D., Hoekstra, P., Hofer, E., Hoffmann, W., Holmes, A., Homuth, G., Hosten, N., Ikram, M., Ipser, J., Jr, C., Jahanshad, N., Jönsson, E., Kahn, R., Kanai, R., Klein, M., Knol, M., Launer, L., Lawrie, S., Le Hellard, S., Lee, P., Lemaître, H., Li, S., Liewald, D., Lin, H., Longstreth, W., Lopez, O., Luciano, M., Maillard, P., Marquand, A., Martin, N., Martinot, J., Mather, K., Mattay, V., McMahon, K., Mecocci, P., Melle, I., Meyer-Lindenberg, A., Mirza-Schreiber, N., Milaneschi, Y., Mosley, T., Mühleisen, T., Müller-Myhsok, B., Maniega, S., Nauck, M., Nho, K., Niessen, W., Nöthen, M., Nyquist, P., Oosterlaan, J., Pandolfo, M., Paus, T., Pausova, Z., Penninx, B., Pike, G., Psaty, B., Pütz, B., Reppermund, S., Rietschel, M., Risacher, S., Romanczuk-Seiferth, N., Romero-Garcia, R., Roshchupkin, G., Rotter, J., Sachdev, P., Sämann, P., Saremi, A., Sargurupremraj, M., Saykin, A., Schmaal, L., Schmidt, H., Schmidt, R., Schofield, P., Scholz, M., Schumann, G., Schwarz, E., Shen, L., Shin, J., Sisodiya, S., Smith, A., Smoller, J., Soininen, H., Steen, V., Stein, D., Stein, J., Thomopoulos, S., Toga, A., Tordesillas-Gutiérrez, D., Trollor, J., Valdes-Hernandez, M., van Ent, D., van Bokhoven, H., van der Meer, D., van der Wee, N., Vázquez-Bourgon, J., Veltman, D., Vernooij, M., Villringer, A., Vinke, L., Völzke, H., Walter, H., Wardlaw, J., Weinberger, D., Weiner, M., Wen, W., Westlye, L., Westman, E., White, T., Witte, A., Wolf, C., Yang, J., Zwiers, M., Seshadri, S., Thompson, P., Satizabal, C., Medland, S., Rentería, M.
Πηγή: Nature Genetics
Έτος έκδοσης: 2024
Συλλογή: Max Planck Society: MPG.PuRe
Περιγραφή: Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. We performed GWAS meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globus pallidus, thalamus, nucleus accumbens, amygdala and, for the first time, the ventral diencephalon) in 74,898 participants of European ancestry. We identified 254 independent loci associated with these brain volumes, explaining up to 35% of phenotypic variance. We observed gene expression in specific neural cell types across differentiation time points, including genes involved in intracellular signalling and brain ageing-related processes. Polygenic scores for brain volumes showed predictive ability when applied to individuals of diverse ancestries. We observed causal genetic effects of brain volumes with Parkinson's disease and ADHD. Findings implicate specific gene expression patterns in brain development and genetic variants in comorbid neuropsychiatric disorders, which could point to a brain substrate and region of action for risk genes implicated in brain diseases.
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Γλώσσα: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/39433889
Διαθεσιμότητα: https://hdl.handle.net/21.11116/0000-000F-BE47-C
https://hdl.handle.net/21.11116/0000-000F-BE49-A
https://hdl.handle.net/21.11116/0000-000F-BE4A-9
https://hdl.handle.net/21.11116/0000-000F-BE4B-8
Rights: info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nd/4.0/
Αριθμός Καταχώρησης: edsbas.E1103211
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  – Url: https://hdl.handle.net/21.11116/0000-000F-BE47-C#
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PubType: Academic Journal
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  Data: Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
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– Name: TitleSource
  Label: Source
  Group: Src
  Data: Nature Genetics
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2024
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: Max Planck Society: MPG.PuRe
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. We performed GWAS meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globus pallidus, thalamus, nucleus accumbens, amygdala and, for the first time, the ventral diencephalon) in 74,898 participants of European ancestry. We identified 254 independent loci associated with these brain volumes, explaining up to 35% of phenotypic variance. We observed gene expression in specific neural cell types across differentiation time points, including genes involved in intracellular signalling and brain ageing-related processes. Polygenic scores for brain volumes showed predictive ability when applied to individuals of diverse ancestries. We observed causal genetic effects of brain volumes with Parkinson's disease and ADHD. Findings implicate specific gene expression patterns in brain development and genetic variants in comorbid neuropsychiatric disorders, which could point to a brain substrate and region of action for risk genes implicated in brain diseases.
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  Group: TypDoc
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  Data: application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: info:eu-repo/semantics/altIdentifier/pmid/39433889
– Name: URL
  Label: Availability
  Group: URL
  Data: https://hdl.handle.net/21.11116/0000-000F-BE47-C<br />https://hdl.handle.net/21.11116/0000-000F-BE49-A<br />https://hdl.handle.net/21.11116/0000-000F-BE4A-9<br />https://hdl.handle.net/21.11116/0000-000F-BE4B-8
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  Label: Rights
  Group: Cpyrght
  Data: info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nd/4.0/
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsbas.E1103211
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.E1103211
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      – TitleFull: Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
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      – PersonEntity:
          Name:
            NameFull: Nöthen, M.
      – PersonEntity:
          Name:
            NameFull: Nyquist, P.
      – PersonEntity:
          Name:
            NameFull: Oosterlaan, J.
      – PersonEntity:
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            NameFull: Pandolfo, M.
      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
          Name:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
            NameFull: Satizabal, C.
      – PersonEntity:
          Name:
            NameFull: Medland, S.
      – PersonEntity:
          Name:
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    IsPartOfRelationships:
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          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-locals
              Value: edsbas
            – Type: issn-locals
              Value: edsbas.oa
          Titles:
            – TitleFull: Nature Genetics
              Type: main
ResultId 1